Pcdhg Complex/Cluster/Region Detail

Summary

• Symbol
  Pcdhg
• Name
  protocadherin gamma cluster
• Synonyms
  PCDHG@

• Feature Type
  complex/cluster/region
• IDs
  MGI:3719124
• Cluster Members
  Pcdhga1, Pcdhga2, Pcdhga3 ... (22 members)
• Regulated by
  Rr424 (1 regulatory region)

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 18, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  36 phenotypes from 14 alleles in 13 genetic backgrounds
  8 phenotypes from multigenic genotypes
  34 phenotype references
  

• All Mutations and Alleles
  45
• Endonuclease-mediated
  30
• Targeted
  15
• Genomic Mutations
  4 involving Pcdhg
• Find Mice (IMSR)
  13 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Expression

• Assay Results
  119
• Tissues
  113
• cDNA Data
  2
• Literature Summary
  7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Molecular
Reagents

• All nucleic 5

  cDNA 2

  Primer pair 3

References

• Summaries
  All 42

  Developmental Gene Expression 7

  Phenotypes 34
• Earliest
  J:78249 Wang X, et al., Molecular mechanisms governing Pcdh-gamma gene expression: evidence for a multiple promoter and cis-alternative splicing model. Genes Dev. 2002 Aug 1;16(15):1890-905
• Latest
  J:358998 Leon WRM, et al., The clustered gamma protocadherin PcdhgammaC4 isoform regulates cortical interneuron programmed cell death in the mouse cortex. Proc Natl Acad Sci U S A. 2024 Feb 6;121(6):e2313596120

Pcdhg expression regulated by:

Feature	Feature Type	Location	Reference
Rr424, regulatory region 424	unclassified other genome feature	Chr18, Syntenic	J:104881

Pcdhg Cluster contains:

More Data for these features

Member	Feature Type	Location
Pcdhga1, protocadherin gamma subfamily A, 1	protein coding gene	Chr18:37794846-37974926 (+)
Pcdhga2, protocadherin gamma subfamily A, 2	protein coding gene	Chr18:37802006-37974923 (+)
Pcdhga3, protocadherin gamma subfamily A, 3	protein coding gene	Chr18:37807388-37974926 (+)
Pcdhgb1, protocadherin gamma subfamily B, 1	protein coding gene	Chr18:37813325-37974923 (+)
Pcdhga4, protocadherin gamma subfamily A, 4	protein coding gene	Chr18:37818290-37974923 (+)
Pcdhgb2, protocadherin gamma subfamily B, 2	protein coding gene	Chr18:37822912-37974925 (+)
Pcdhga5, protocadherin gamma subfamily A, 5	protein coding gene	Chr18:37827433-37974926 (+)
Pcdhga6, protocadherin gamma subfamily A, 6	protein coding gene	Chr18:37840154-37974923 (+)
Pcdhga7, protocadherin gamma subfamily A, 7	protein coding gene	Chr18:37847887-37974926 (+)
Pcdhgb4, protocadherin gamma subfamily B, 4	protein coding gene	Chr18:37853429-37974923 (+)
Pcdhga8, protocadherin gamma subfamily A, 8	protein coding gene	Chr18:37858759-37974926 (+)
Pcdhgb5, protocadherin gamma subfamily B, 5	protein coding gene	Chr18:37864062-37974926 (+)
Pcdhga9, protocadherin gamma subfamily A, 9	protein coding gene	Chr18:37869989-37974916 (+)
Pcdhgb6, protocadherin gamma subfamily B, 6	protein coding gene	Chr18:37875147-37974926 (+)
Pcdhga10, protocadherin gamma subfamily A, 10	protein coding gene	Chr18:37880069-37974923 (+)
Pcdhgb7, protocadherin gamma subfamily B, 7	protein coding gene	Chr18:37884672-37974923 (+)
Pcdhga11, protocadherin gamma subfamily A, 11	protein coding gene	Chr18:37888826-37974926 (+)
Pcdhgb8, protocadherin gamma subfamily B, 8	polymorphic pseudogene	Chr18:37894854-37973542 (+)
Pcdhga12, protocadherin gamma subfamily A, 12	protein coding gene	Chr18:37898633-37974926 (+)
Pcdhgc3, protocadherin gamma subfamily C, 3	protein coding gene	Chr18:37939463-37974926 (+)
Pcdhgc4, protocadherin gamma subfamily C, 4	protein coding gene	Chr18:37948132-37974926 (+)
Pcdhgc5, protocadherin gamma subfamily C, 5	protein coding gene	Chr18:37952599-37974926 (+)