Pcdhgb7 Gene Detail

Summary

• Symbol
  Pcdhgb7
• Name
  protocadherin gamma subfamily B, 7

• Feature Type
  protein coding gene
• IDs
  MGI:1935199
  NCBI Gene: 93704
• Member of
  Pcdhg cluster
• Alliance
  genome feature page
• Transcription Start Sites
  1 TSS
• Regulated by
  Rr72, Rr73, Rr74 ... (4 regulatory regions)

Location &
Maps

• Sequence Map
  Chr18:37884672-37974923 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 18, 19.62 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  2553 from dbSNP Build 142
• Strain Annotations
  17

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1935199	protein coding gene	Chr18:37884672-37974923 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024348	protein coding gene	Chr18:36158529-36259977 (+)
A/J	no annotation
AKR/J	MGP_AKRJ_G0024284	protein coding gene	Chr18:35876830-35972570 (+)
BALB/cJ	MGP_BALBcJ_G0024315	protein coding gene	Chr18:34985644-35077409 (+)
C3H/HeJ	MGP_C3HHeJ_G0024081	protein coding gene	Chr18:35947006-36038769 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024757	protein coding gene	Chr18:37456946-37559702 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022196	protein coding gene	Chr18:34936548-35028291 (+)
CAST/EiJ	MGP_CASTEiJ_G0023556	protein coding gene	Chr18:35880219-35977834 (+)
CBA/J	MGP_CBAJ_G0024051	protein coding gene	Chr18:38568913-38667943 (+)
DBA/2J	MGP_DBA2J_G0024181	protein coding gene	Chr18:34521003-34611340 (+)
FVB/NJ	MGP_FVBNJ_G0024147	protein coding gene	Chr18:34229666-34321591 (+)
LP/J	MGP_LPJ_G0024265	protein coding gene	Chr18:36229478-36321813 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024178	protein coding gene	Chr18:39832978-39929365 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024806	protein coding gene	Chr18:35731919-35837204 (+)
PWK/PhJ	MGP_PWKPhJ_G0023300	protein coding gene	Chr18:34724519-34819114 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023105	protein coding gene	Chr18:35960506-36054330 (+)
WSB/EiJ	MGP_WSBEiJ_G0023619	protein coding gene	Chr18:35636823-35737854 (+)

Homology

• Human Ortholog
  PCDHGB7, protocadherin gamma subfamily B, 7

• Vertebrate Orthologs
  24

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  PCDHGB7, protocadherin gamma subfamily B, 7
  
• Synonyms
  ME6, PCDH-GAMMA-B7
• Links
  HGNC:8714

  NCBI Gene ID: 56099

  UniProt: Q9Y5F8

  
  
• Chr Location
  5q31.3; chr5:141417645-141512975 (+)  GRCh38

---

• MGI Vertebrate Homology
  Pcdhgb7 stringent orthology
  1 human;1 mouse;23 zebrafish
  
• HCOP
  vertebrate homology predictions: PCDHGB7

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotype references
  

• All Mutations and Alleles
  6
• Endonuclease-mediated
  2
• Targeted
  4
• Genomic Mutations
  5 involving Pcdhgb7
• Find Mice (IMSR)
  75 strains or lines available

Expression

• Assay Results
  5
• Tissues
  3
• cDNA Data
  3
• Literature Summary
  5

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  27
• RefSeq
  2
• UniProt
  3
• CCDS
  CCDS79633.1

• NCBI Gene
  93704

Representative Sequences			Length	Strain/Species
genomic	93704	NCBI Gene Model | MGI Sequence Detail	90252	C57BL/6J
transcript	NM_033579	RefSeq | MGI Sequence Detail	4691	C57BL/6
polypeptide	NP_291057	RefSeq | MGI Sequence Detail	929	C57BL/6

Protein
Information

• UniProt
  3 Sequences
• PDB
  5SZO, 5SZP, 5V5X
• InterPro Domains
  IPR020894 Cadherin conserved site
  IPR031904 Cadherin, C-terminal catenin-binding domain
  IPR032455 Cadherin, cytoplasmic C-terminal domain
  IPR002126 Cadherin-like
  IPR015919 Cadherin-like superfamily
  IPR013164 Cadherin, N-terminal
  IPR050174 Protocadherin/Cadherin-related Cell Adhesion
• GlyGen
  Q91XX3 11 sites, 2 N-linked glycans (2 sites)

Molecular
Reagents

• All nucleic 9

  Genomic 2

  cDNA 3

  Primer pair 4

References

• Summaries
  All 23

  Developmental Gene Expression 5

  Phenotypes 6
• Earliest
  J:86878 Wu Q, et al., A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90
• Latest
  J:332241 Kobayashi H, et al., Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality. iScience. 2023 Jan 20;26(1):105766

Pcdhgb7 expression regulated by:

Feature	Feature Type	Location	Reference
Rr72, regulatory region 72	unclassified other genome feature	Chr18, Syntenic	J:277249
Rr73, regulatory region 73	unclassified other genome feature	Chr18, Syntenic	J:277249
Rr74, regulatory region 74	unclassified other genome feature	Chr18, Syntenic	J:277249
Rr75, regulatory region 75	unclassified other genome feature	Chr18, Syntenic	J:277249

TSS for Pcdhgb7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150733	Chr18:37884654-37884705 (+)	8 bp