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Tgm2 Gene Detail
Summary
  • Symbol
    Tgm2
  • Name
    transglutaminase 2, C polypeptide
  • Synonyms
    G[a]h, protein-glutamine gamma-glutamyltransferase, TG2, TGase2, TG C, tissue transglutaminase, tTG, tTGas
  • Feature Type
    protein coding gene
  • IDs
    MGI:98731
    NCBI Gene: 21817
  • Alliance
    genome feature page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:157958325-157988312 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 78.72 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1048 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98731
 protein coding gene Chr2:157958322-157988356 (-)
129S1/SvImJ ENSMUSG00200015757
 protein coding gene Chr2:154820672-154850693 (-)
A/J ENSMUSG00195021287
 protein coding gene Chr2:155190137-155220166 (-)
AKR/J ENSMUSG00220012953
 protein coding gene Chr2:154518627-154548637 (-)
BALB/cJ ENSMUSG00180047455
 protein coding gene Chr2:154643074-154673099 (-)
C3H/HeJ ENSMUSG00175050877
 protein coding gene Chr2:155393241-155423270 (-)
C57BL/6NJ ENSMUSG00215032812
 protein coding gene Chr2:154807910-154837943 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024583
 protein coding gene Chr2:150079074-150109078 (-)
CAST/EiJ ENSTCUG00005045604
 protein coding gene Chr2:153792250-153822199 (-)
CBA/J ENSMUSG00210015274
 protein coding gene Chr2:155324340-155354368 (-)
DBA/2J ENSMUSG00185046635
 protein coding gene Chr2:155042906-155072915 (-)
FVB/NJ ENSMUSG00205031268
 protein coding gene Chr2:154075433-154105458 (-)
JF1/MsJ ENSUMUG00000009758
 protein coding gene Chr2:154693980-154724136 (-)
LP/J ENSMUSG00230045094
 protein coding gene Chr2:156618221-156648229 (-)
NOD/ShiLtJ ENSMUSG00190038162
 protein coding gene Chr2:154718349-154748375 (-)
NZO/HlLtJ ENSMUSG00225049801
 protein coding gene Chr2:164633477-164663449 (-)
PWK/PhJ ENSLUMG00010042912
 protein coding gene Chr2:154636089-154666249 (-)
SPRET/EiJ ENSMSPG00010032827
 protein coding gene Chr2:157394433-157424239 (-)
WSB/EiJ ENSIUOG00005043857
 protein coding gene Chr2:154410896-154440717 (-)



Homology
more
  • Human Ortholog
    TGM2, transglutaminase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TGM2, transglutaminase 2
  • Synonyms
    G(h), hTG2, TG(C), TGC, tTG
  • Links
    NCBI Gene ID: 7052
    UniProt: P21980

  • Chr Location
    20q11.23; chr20:38127385-38168475 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tgm2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 4 alleles in 8 genetic backgrounds
    10 phenotypes from multigenic genotypes
    105 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A homozygous null mutation causes alterations in glucose and aerobic energy metabolism, tumor growth, and response to myocardial infarction, liver injury, and LPS-induced sepsis. A second null mutation confers resistance to renal injury, while a third one alters cell adhesion and T cell physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    139
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1233
  • Tissues
    273
  • cDNA Data
    204
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21817 NCBI Gene Model | MGI Sequence Detail 29988 C57BL/6J ±  kb
    transcript NM_009373 RefSeq | MGI Sequence Detail 3549 ZRU/MplStud  
    polypeptide P21981 UniProt | EBI | MGI Sequence Detail 686 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 222
      Genomic 4
      cDNA 205
      Primer pair 11
      Other 2
      Antibodies 7

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-15073
    References
    more
    • Summaries
      All 220
      Developmental Gene Expression 24
      Diseases 3
      Gene Ontology 24
      Phenotypes 105
    • Earliest
      J:10915 Gentile V, et al., Isolation and characterization of cDNA clones to mouse macrophage and human endothelial cell tissue transglutaminases. J Biol Chem. 1991 Jan 5;266(1):478-83
    • Latest
      J:387078 Elizondo DM, et al., Transglutaminase 2-expressing macrophages modulate adipose tissue inflammation. Commun Biol. 2025 Jun 4;8(1):859
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory