Phenotypes Associated with This Genotype

Genotype
MGI:3029267

• Allelic Composition: Tgm2^tm1Gml/Tgm2^tm1Gml
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:82489 )

• increased death (~60% of treated mice died) after carbon tetrachloride (CCl4) administration

hematopoietic system

decreased erythrocyte cell number ( J:75566 )

• small, but significant

decreased hematocrit ( J:75566 )

• small, but significant

homeostasis/metabolism

hyperglycemia ( J:78633 )

• in fed, but not fasted, state

decreased circulating insulin level ( J:78633 )

• after intraperitoneal glucose administration

impaired glucose tolerance ( J:78633 )

• glucose intolerance after intraperitoneal glucose administration

increased insulin sensitivity ( J:78633 )

• greater hypoglyemic response than controls upon intraperitoneal insulin administration

increased physiological sensitivity to xenobiotic ( J:82489 )

• in those that survived, increased hepatic injury after CCl4 administration

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young		DOID:0050524	OMIM:606391	J:75566 , J:78633 , J:82489