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Rag1 Gene Detail
Summary
  • Symbol
    Rag1
  • Name
    recombination activating 1
  • Synonyms
    Rag-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97848
    NCBI Gene: 19373
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
  • Regulated by
    Rr695557 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr2:101468627-101479846 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 53.88 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    411 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97848
 protein coding gene Chr2:101468597-101479877 (-)
129S1/SvImJ ENSMUSG00200002316
 protein coding gene Chr2:98270995-98282211 (-)
A/J ENSMUSG00195000638
 protein coding gene Chr2:98446108-98457325 (-)
AKR/J ENSMUSG00220001598
 protein coding gene Chr2:98199675-98210893 (-)
BALB/cJ ENSMUSG00180019109
 protein coding gene Chr2:98255087-98266305 (-)
C3H/HeJ ENSMUSG00175009834
 protein coding gene Chr2:98524518-98535736 (-)
C57BL/6NJ ENSMUSG00215015872
 protein coding gene Chr2:98349835-98361054 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024002
 protein coding gene Chr2:94942211-94953437 (-)
CAST/EiJ ENSTCUG00005001564
 protein coding gene Chr2:97610578-97621822 (-)
CBA/J ENSMUSG00210001843
 protein coding gene Chr2:98533141-98544358 (-)
DBA/2J ENSMUSG00185005580
 protein coding gene Chr2:98252111-98263328 (-)
FVB/NJ ENSMUSG00205010712
 protein coding gene Chr2:97550648-97561871 (-)
JF1/MsJ ENSUMUG00000026635
 protein coding gene Chr2:97943051-97954269 (-)
LP/J ENSMUSG00230000723
 protein coding gene Chr2:100001578-100012795 (-)
NOD/ShiLtJ ENSMUSG00190021942
 protein coding gene Chr2:98353450-98364667 (-)
NZO/HlLtJ ENSMUSG00225008482
 protein coding gene Chr2:107892510-107903728 (-)
PWK/PhJ ENSLUMG00010023439
 protein coding gene Chr2:97930401-97941620 (-)
SPRET/EiJ ENSMSPG00010008664
 protein coding gene Chr2:99945287-99954310 (-)
WSB/EiJ ENSIUOG00005001210
 protein coding gene Chr2:98036402-98047618 (-)



Homology
more
  • Human Ortholog
    RAG1, recombination activating 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAG1, recombination activating 1
  • Synonyms
    RAG-1, RNF74
  • Links
    NCBI Gene ID: 5896
    UniProt: P15918

  • Chr Location
    11p12; chr11:36510353-36593156 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human RAG1 associations

Human Disease Mouse Models
      
IDs
IDs
 View 1 "NOT" model
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    76 phenotypes from 15 alleles in 23 genetic backgrounds
    200 phenotypes from multigenic genotypes
    1 images
    2641 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit arrested development of T and B cell maturation at the CD4-8- thymocyte or B220+/CD43+pro-B cell stage due to inability to undergo V(D)J recombination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    783
  • Tissues
    110
  • cDNA Data
    24
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061311 Ensembl Gene Model | MGI Sequence Detail 11220 C57BL/6J ±  kb
    transcript ENSMUST00000078494 Ensembl | MGI Sequence Detail 6608 Not Applicable  
    polypeptide ENSMUSP00000077584 Ensembl | MGI Sequence Detail 1040 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      Genomic 13
      cDNA 26
      Primer pair 6
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13753, MGD-MRK-13755
    References
    more
    • Summaries
      All 2864
      Developmental Gene Expression 19
      Diseases 6
      Gene Ontology 28
      Phenotypes 2641
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:391825 Matoba K, et al., Circulating extracellular vesicle microRNAs mediate immune modulation of social behavior in male mice. Nat Commun. 2026 Apr 3;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory