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Mpl Gene Detail
Summary
  • Symbol
    Mpl
  • Name
    Mpl proto-oncogene, thrombopoietin receptor
  • Synonyms
    CD110, c-mpl, c-mpl-I, c-mpl-II, hlb219, thrombopoietin receptor, TPO-R
  • Feature Type
    protein coding gene
  • IDs
    MGI:97076
    NCBI Gene: 17480
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:118299612-118314710 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 54.61 cM, cytoband D
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    414 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97076
 protein coding gene Chr4:118299609-118314771 (-)
129S1/SvImJ ENSMUSG00200011279
 protein coding gene Chr4:112198426-112213537 (-)
A/J ENSMUSG00195026657
 protein coding gene Chr4:113450064-113465076 (-)
AKR/J ENSMUSG00220019027
 protein coding gene Chr4:112797809-112812910 (-)
BALB/cJ ENSMUSG00180040232
 protein coding gene Chr4:111517265-111532202 (-)
C3H/HeJ ENSMUSG00175023390
 protein coding gene Chr4:112531452-112546376 (-)
C57BL/6NJ ENSMUSG00215020090
 protein coding gene Chr4:113624621-113639708 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026376
 protein coding gene Chr4:108882423-108897242 (-)
CAST/EiJ ENSTCUG00005043418
 protein coding gene Chr4:112304831-112319767 (-)
CBA/J ENSMUSG00210051957
 protein coding gene Chr4:112145141-112160061 (-)
DBA/2J ENSMUSG00185040541
 protein coding gene Chr4:113675568-113690587 (-)
FVB/NJ ENSMUSG00205026896
 protein coding gene Chr4:111614598-111629531 (-)
JF1/MsJ ENSUMUG00000005053
 protein coding gene Chr4:113592426-113607360 (-)
LP/J ENSMUSG00230043090
 protein coding gene Chr4:117013986-117029074 (-)
NOD/ShiLtJ ENSMUSG00190043460
 protein coding gene Chr4:111512932-111527832 (-)
NZO/HlLtJ ENSMUSG00225010584
 protein coding gene Chr4:122496347-122511289 (-)
PWK/PhJ ENSLUMG00010038260
 protein coding gene Chr4:110975842-110991023 (-)
SPRET/EiJ ENSMSPG00010037566
 protein coding gene Chr4:113063309-113079330 (-)
WSB/EiJ ENSIUOG00005043390
 protein coding gene Chr4:111830770-111845770 (-)



Homology
more
  • Human Ortholog
    MPL, MPL proto-oncogene, thrombopoietin receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MPL, MPL proto-oncogene, thrombopoietin receptor
  • Synonyms
    CD110, C-MPL, MPLV, THCYT2, THPOR, TPOR
  • Links
    NCBI Gene ID: 4352
    UniProt: P40238

  • Chr Location
    1p34.2; chr1:43337808-43354466 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mpl mouse models; 5 with human MPL associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 7 alleles in 8 genetic backgrounds
    26 phenotypes from multigenic genotypes
    97 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations at this locus are unable to produce normal amounts of megakaryocytes and platelets.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    931
  • Tissues
    153
  • cDNA Data
    19
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000006389 Ensembl Gene Model | MGI Sequence Detail 15099 C57BL/6J ±  kb
    transcript ENSMUST00000006556 Ensembl | MGI Sequence Detail 2083 Not Applicable  
    polypeptide ENSMUSP00000006556 Ensembl | MGI Sequence Detail 633 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 1
      cDNA 19
      Primer pair 11
      Other 3
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12409, MGI:2678710
    References
    more
    • Summaries
      All 185
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 11
      Phenotypes 97
    • Earliest
      J:9693 Wendling F, et al., Factor-independent erythropoietic progenitor cells in leukemia induced by the myeloproliferative leukemia virus. Blood. 1989 Apr;73(5):1161-7
    • Latest
      J:386744 Zhang S, et al., Physiological MplW514L expression in hematopoietic stem cell causes an essential thrombocythemia and progressive myelofibrosis. J Clin Invest. 2026 Jun 1;136(11)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory