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Phenotypes Associated with This Genotype
Genotype
MGI:2686902
Allelic
Composition
Mpltm1Fjs/Mpltm1Fjs
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpltm1Fjs mutation (0 available); any Mpl mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• levels of megakaryocyte progenitors reduced by about 50%
• fewer megakaryocytes generated in response to thrombopoietin and the ploidy of cells produced was lower
• less of an increase in platelets 5 days after thrombopoietin treatment

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congenital amegakaryocytic thrombocytopenia DOID:0090118 OMIM:604498
J:87416


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory