Mpl Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mpl
myeloproliferative leukemia virus oncogene
MGI:97076

24 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mpl^hlb219/Mpl⁺ C57BL/6J-Mpl^hlb219/J	abnormal definitive hematopoiesis	J:146577
	decreased erythrocyte cell number	J:146577
	decreased hemoglobin content	J:146577
	thrombocytosis	J:146577
Mpl^hlb219/Mpl^hlb219 C57BL/6J-Mpl^hlb219/J	abnormal circulating cytokine level	J:146577
	abnormal definitive hematopoiesis	J:146577
	abnormal megakaryocyte progenitor cell morphology	J:146577
	anemia	J:146577
	decreased common myeloid progenitor cell number	J:146577
	decreased erythrocyte cell number	J:146577
	decreased hematocrit	J:146577
	decreased hemoglobin content	J:146577
	decreased leukocyte cell number	J:146577
	decreased megakaryocyte cell number	J:146577
	enlarged spleen	J:146577
	increased bleeding time	J:146577
	thrombocytopenia	J:82961, J:146577
Mpl^tm1Fjs/Mpl^tm1Fjs involves: 129 * C57BL/6J	abnormal definitive hematopoiesis	J:87416
Mpl^tm1Fjs/Mpl^tm1Fjs involves: 129 * C57BL/6J	abnormal megakaryocyte progenitor cell morphology	J:87416
Mpl^tm1Mwm/Mpl^tm1Mwm B6;129S2	absent megakaryocytes	J:83264
	normal immune system phenotype	J:83264
	increased mean platelet volume	J:83264
	thrombocytopenia	J:83264
Mpl^tm1Wsa/Mpl^tm1Wsa involves: 129S1/Sv	abnormal circulating chemokine level	J:162629
Mpl^tm1Wsa/Mpl^tm1Wsa involves: 129S1/Sv	thrombocytopenia	J:162629
Mpl^tm1Wsa/Mpl^tm1Wsa involves: 129S1/Sv * C57BL/6	abnormal megakaryocyte progenitor cell morphology	J:32131
	absent megakaryocytes	J:32131
	decreased hematopoietic stem cell number	J:32131
	normal immune system phenotype	J:32131
	thrombocytopenia	J:32131
Mpl^tm2.1Wsa/Mpl^tm2.1Wsa Tg(Pf4-icre)Q3Rsko/0 involves: C57BL/6	abnormal common myeloid progenitor cell morphology	J:208120
	abnormal megakaryocyte morphology	J:208120
	decreased erythroid progenitor cell number	J:208120
	enlarged spleen	J:208120
	increased hematopoietic stem cell proliferation	J:208120
	increased megakaryocyte cell number	J:208120
	thrombocytosis	J:208120
Mpl^tm2.2Wsa/Mpl^tm2.2Wsa involves: BALB/cJ * C57BL/6	thrombocytopenia	J:208120

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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