Mpl^tm1Mwm
Targeted Allele Detail

Summary

• Symbol: Mpl^tm1Mwm
• Name: myeloproliferative leukemia virus oncogene; targeted mutation 1, Mark W Moore
• MGI ID: MGI:2660810
• Synonyms: c-mpl -
• Gene: Mpl Location: Chr4:118299612-118314710 bp, - strand Genetic Position: Chr4, 54.61 cM, cytoband D
• Alliance: Mpl^tm1Mwm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83264
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin selection cassette was inserted into exon 3. (J:83264)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mpl Mutation: 46 strains or lines available

References

• Original: J:83264 Gurney AL, et al., Thrombocytopenia in c-mpl-deficient mice. Science. 1994 Sep 2;265(5177):1445-7
• All: 19 reference(s)