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Lrp1 Gene Detail
Summary
  • Symbol
    Lrp1
  • Name
    low density lipoprotein receptor-related protein 1
  • Synonyms
    A2mr, b2b1554Clo, CD91
  • Feature Type
    protein coding gene
  • IDs
    MGI:96828
    NCBI Gene: 16971
  • Alliance
    genome feature page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127374030-127457017 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 74.52 cM, cytoband B2-D1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1968 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96828
 protein coding gene Chr10:127374026-127457158 (-)
129S1/SvImJ ENSMUSG00200012714
 protein coding gene Chr10:123727018-123810009 (-)
A/J ENSMUSG00195015256
 protein coding gene Chr10:124190304-124272763 (-)
AKR/J ENSMUSG00220004518
 protein coding gene Chr10:123795662-123878659 (-)
BALB/cJ ENSMUSG00180011320
 protein coding gene Chr10:124181365-124263818 (-)
C3H/HeJ ENSMUSG00175005694
 protein coding gene Chr10:124180596-124263107 (-)
C57BL/6NJ ENSMUSG00215017542
 protein coding gene Chr10:123792219-123875214 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015901
 protein coding gene Chr10:119892673-119977329 (-)
CAST/EiJ ENSTCUG00005039386
 protein coding gene Chr10:123163798-123246864 (-)
CBA/J ENSMUSG00210008697
 protein coding gene Chr10:124004789-124087296 (-)
DBA/2J ENSMUSG00185025804
 protein coding gene Chr10:124159058-124242055 (-)
FVB/NJ ENSMUSG00205015151
 protein coding gene Chr10:123400849-123483830 (-)
JF1/MsJ ENSUMUG00000039380
 protein coding gene Chr10:125453325-125536175 (-)
LP/J ENSMUSG00230028728
 protein coding gene Chr10:126074314-126157302 (-)
NOD/ShiLtJ ENSMUSG00190015310
 protein coding gene Chr10:124223036-124306010 (-)
NZO/HlLtJ ENSMUSG00225036003
 protein coding gene Chr10:130276819-130359815 (-)
PWK/PhJ ENSLUMG00010009153
 protein coding gene Chr10:123914034-123996988 (-)
SPRET/EiJ ENSMSPG00010035593
 protein coding gene Chr10:125866838-125949980 (-)
WSB/EiJ ENSIUOG00005007529
 protein coding gene Chr10:123791064-123873901 (-)



Homology
more
  • Human Ortholog
    LRP1, LDL receptor related protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRP1, LDL receptor related protein 1
  • Synonyms
    A2MR, APOER, APR, CD91, DDH3, IGFBP-3R, IGFBP3R, IGFBP3R1, KPA, LRP, LRP1A, TGFBR5
  • Links
    NCBI Gene ID: 4035
    UniProt: Q07954

  • Chr Location
    12q13.3; chr12:57128483-57213361 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with Lrp1 mouse models; 4 with human LRP1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    113 phenotypes from 10 alleles in 10 genetic backgrounds
    34 phenotypes from multigenic genotypes
    20 images
    158 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit lethality during late organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    175
  • GO References
    39
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    936
  • Tissues
    125
  • cDNA Data
    318
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040249 Ensembl Gene Model | MGI Sequence Detail 82988 C57BL/6J ±  kb
    transcript ENSMUST00000049149 Ensembl | MGI Sequence Detail 14888 Not Applicable  
    polypeptide ENSMUSP00000044004 Ensembl | MGI Sequence Detail 4545 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000002058 low-density lipoprotein receptor-related protein 1
      (term hierarchy)
    • InterPro Domains
      IPR026823 Complement Clr-like EGF domain
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR013032 EGF-like, conserved site
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR000033 LDLR class B repeat
      IPR036055 LDL receptor-like superfamily
      IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
      IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
      IPR051221 Low-density lipoprotein receptor-related
      IPR051830 Neurogenic locus notch homolog
      IPR049883 NOTCH1, EGF-like calcium-binding domain
      IPR011042 Six-bladed beta-propeller, TolB-like
    • GlyGen
      Q91ZX7 55 sites, 51 N-linked glycans (37 sites), 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 329
      Genomic 7
      cDNA 320
      Primer pair 2
      Antibodies 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1007, MGD-MRK-11886, MGI:2143570, MGI:5437071
    References
    more
    • Summaries
      All 356
      Developmental Gene Expression 32
      Diseases 4
      Gene Ontology 39
      Phenotypes 158
    • Earliest
      J:30078 Herz J, et al., Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J. 1988 Dec 20;7(13):4119-27
    • Latest
      J:389438 Srinivasan T, et al., The gut microbiota directs vitamin A flux to regulate intestinal T cell development. Cell Host Microbe. 2026 Jun 17;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory