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Gad2 Gene Detail
Summary
  • Symbol
    Gad2
  • Name
    glutamic acid decarboxylase 2
  • Synonyms
    6330404F12Rik, Gad-2, GAD(65), GAD65
  • Feature Type
    protein coding gene
  • IDs
    MGI:95634
    NCBI Gene: 14417
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
  • Regulated by
    Rr469 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr2:22512262-22583889 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 15.15 cM, cytoband A-B
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2155 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95634
 protein coding gene Chr2:22512217-22583889 (+)
129S1/SvImJ ENSMUSG00200041870
 protein coding gene Chr2:19490062-19561745 (+)
A/J ENSMUSG00195018569
 protein coding gene Chr2:19583718-19656805 (+)
AKR/J ENSMUSG00220013088
 protein coding gene Chr2:19704887-19777970 (+)
BALB/cJ ENSMUSG00180035732
 protein coding gene Chr2:19591182-19662858 (+)
C3H/HeJ ENSMUSG00175022043
 protein coding gene Chr2:19555825-19627499 (+)
C57BL/6NJ ENSMUSG00215022353
 protein coding gene Chr2:19615596-19687263 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023222
 protein coding gene Chr2:18614120-18684356 (+)
CAST/EiJ ENSTCUG00005004358
 protein coding gene Chr2:19315069-19384931 (+)
CBA/J ENSMUSG00210003336
 protein coding gene Chr2:19594817-19666498 (+)
DBA/2J ENSMUSG00185037540
 protein coding gene Chr2:19498128-19571201 (+)
FVB/NJ ENSMUSG00205013264
 protein coding gene Chr2:19518830-19591721 (+)
JF1/MsJ ENSUMUG00000003440
 protein coding gene Chr2:19377728-19447807 (+)
LP/J ENSMUSG00230039460
 protein coding gene Chr2:21426070-21497745 (+)
NOD/ShiLtJ ENSMUSG00190013283
 protein coding gene Chr2:19585800-19657481 (+)
NZO/HlLtJ ENSMUSG00225001213
 protein coding gene Chr2:29176683-29248349 (+)
PWK/PhJ ENSLUMG00010032182
 protein coding gene Chr2:19458925-19528841 (+)
SPRET/EiJ ENSMSPG00010014537
 protein coding gene Chr2:20071523-20141716 (+)
WSB/EiJ ENSIUOG00005014827
 protein coding gene Chr2:19406747-19478160 (+)



Homology
more
  • Human Ortholog
    GAD2, glutamate decarboxylase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GAD2, glutamate decarboxylase 2
  • Synonyms
    GAD65
  • Links
    NCBI Gene ID: 2572
    UniProt: Q05329

  • Chr Location
    10p12.1; chr10:26216372-26304558 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Gad2 mouse models; 7 with human GAD2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 7 alleles in 8 genetic backgrounds
    29 phenotypes from multigenic genotypes
    730 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit spontaneous (frequently fatal) seizures, increased anxiety-like behavior, and reduced intermale aggression. Heterozygotes show reduced aggressiveness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1511
  • Tissues
    313
  • cDNA Data
    17
  • Literature Summary
    187
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14417 NCBI Gene Model | MGI Sequence Detail 71628 C57BL/6J ±  kb
    transcript NM_008078 RefSeq | MGI Sequence Detail 5625 ZRU/MplStud  
    polypeptide P48320 UniProt | EBI | MGI Sequence Detail 585 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000007786 glutamate decarboxylase 2
      (term hierarchy)
    • EC
      4.1.1.15
    • InterPro Domains
      IPR021115 Pyridoxal-phosphate binding site
      IPR002129 Pyridoxal phosphate-dependent decarboxylase, major domain
      IPR015424 Pyridoxal phosphate-dependent transferase
      IPR015421 Pyridoxal phosphate-dependent transferase, major domain
    • GlyGen
      P48320 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 1
      cDNA 23
      Primer pair 12
      Other 5
      Antibodies 16

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-9955, MGD-MRK-9959, MGI:1918008
    References
    more
    • Summaries
      All 988
      Developmental Gene Expression 187
      Diseases 3
      Gene Ontology 9
      Phenotypes 730
    • Earliest
      J:16802 Maxson SC, et al., Electroencephalographic correlates of the audiogenic seizure response of inbred mice. Physiol Behav. 1976 May;16(5):623-9
    • Latest
      J:390306 Bartas K, et al., Drug-induced changes in connectivity to midbrain dopamine cells revealed by rabies monosynaptic tracing. Elife. 2026 May 15;13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory