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Apob Gene Detail
Summary
  • Symbol
    Apob
  • Name
    apolipoprotein B
  • Synonyms
    apob-100, apob-48
  • Feature Type
    protein coding gene
  • IDs
    MGI:88052
    NCBI Gene: 238055
  • Alliance
  • Transcription Start Sites
    105 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:8027648-8066835 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 3.53 cM
  • Mapping Data
    26 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1000 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88052
protein coding gene Chr12:8027629-8066839 (+)
129S1/SvImJ ENSMUSG00200023027
protein coding gene Chr12:4997459-5036645 (+)
A/J ENSMUSG00195013813
protein coding gene Chr12:5030561-5070267 (+)
AKR/J ENSMUSG00220026043
protein coding gene Chr12:5058313-5097985 (+)
BALB/cJ ENSMUSG00180014991
protein coding gene Chr12:5026919-5066624 (+)
C3H/HeJ ENSMUSG00175009313
protein coding gene Chr12:5011196-5050868 (+)
C57BL/6NJ ENSMUSG00215012921
protein coding gene Chr12:4954698-4993887 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017597
protein coding gene Chr12:4684974-4723162 (+)
CAST/EiJ ENSTCUG00005021556
protein coding gene Chr12:4821915-4861093 (+)
CBA/J ENSMUSG00210013250
protein coding gene Chr12:5042417-5082091 (+)
DBA/2J ENSMUSG00185019845
protein coding gene Chr12:5001708-5040897 (+)
FVB/NJ ENSMUSG00205003049
protein coding gene Chr12:4810315-4849506 (+)
JF1/MsJ ENSUMUG00000019835
protein coding gene Chr12:4974520-5013704 (+)
LP/J ENSMUSG00230011149
protein coding gene Chr12:6831717-6870904 (+)
NOD/ShiLtJ ENSMUSG00190007952
protein coding gene Chr12:6245901-6285088 (+)
NZO/HlLtJ ENSMUSG00225018070
protein coding gene Chr12:8891767-8931475 (+)
PWK/PhJ ENSLUMG00010016308
protein coding gene Chr12:4799712-4838928 (+)
SPRET/EiJ ENSMSPG00010004735
protein coding gene Chr12:5337399-5377321 (+)
WSB/EiJ ENSIUOG00005002046
protein coding gene Chr12:5045855-5085502 (+)



Homology
more
  • Human Ortholog
    APOB, apolipoprotein B
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APOB, apolipoprotein B
  • Synonyms
    apoB-100, apoB-48, FCHL2, FLDB, LDLCQ4
  • Links
    NCBI Gene ID: 338
    UniProt: P04114

  • Chr Location
    2p24.1; chr2:21001429-21044073 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with Apob mouse models; 13 with human APOB associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 11 alleles in 8 genetic backgrounds
    40 phenotypes from multigenic genotypes
    3 images
    111 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants usually die by midgestation and longer survivors exhibit exencephaly. Heterozygotes show reduced plasma cholesterol and apolipoprotein levels. Single isoform B100 and B48 null mutants are viable.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020609 Ensembl Gene Model | MGI Sequence Detail 39188 C57BL/6J ±  kb
    transcript ENSMUST00000037811 Ensembl | MGI Sequence Detail 13934 Not Applicable  
    polypeptide ENSMUSP00000036044 Ensembl | MGI Sequence Detail 4505 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      Genomic 4
      cDNA 61
      Primer pair 10
      Other 2
      Antibodies 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1370, MGI:2144785
    References
    more
    • Summaries
      All 270
      Developmental Gene Expression 28
      Diseases 4
      Gene Ontology 31
      Phenotypes 111
    • Earliest
      J:24996 Mahley RW, et al., Plasma lipoproteins: apolipoprotein structure and function. J Lipid Res. 1984 Dec 1;25(12):1277-94
    • Latest
      J:376678 Ord T, et al., Single-cell to pre-clinical evaluation of Trem2, Folr2, and Slc7a7 as macrophage-associated biomarkers for atherosclerosis. Cardiovasc Res. 2025 Dec 18;121(16):2503-2519

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/01/2026
    MGI 6.24
    The Jackson Laboratory