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Gene Expression Data
Assay Details
Assay
Reference: J:355262 Kadhim AZ, et al., Transcriptional coactivator MED15 is required for beta cell maturation. Nat Commun. 2024 Oct 8;15(1):8711
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8166967
Gene symbol: Ins2
Gene name: insulin II
Antibody: anti-Ins
Results
Specimen 1B Ins: embryonic day 13.5 (more )
Note: Triple labeled: red - Ins2 and Ins1; white - Gcg (assay MGI:8166935); green - Med15 (assay MGI:8166933).
Structure Cell Type Level Pattern Image Note
TS21: pancreas type B pancreatic cell Present 1B (upper) Expression in beta-cells.
Specimen 1C Ins: embryonic day 18.5 (more )
Note: Triple labeled: red - Ins2 and Ins1; white - Gcg (assay MGI:8166935); green - Med15 (assay MGI:8166933).
Structure Cell Type Level Pattern Image Note
TS26: pancreas type B pancreatic cell Present 1C (upper) Expression in beta-cells.
Specimen 1D Ins: postnatal week 8 (more )
Note: Triple labeled: red - Ins2 and Ins1; white - Gcg (assay MGI:8166935); green - Med15 (assay MGI:8166933).
Structure Cell Type Level Pattern Image Note
TS28: pancreas type B pancreatic cell Present 1D (upper) Expression in beta-cells.
Specimen 2B CTRL Ins: postnatal week 8; Ins1tm1.1(cre)Thor/Ins1+ (more )
Note: Double labeled: red - Ins2 and Ins1; green - Med15 (assay MGI:8166933).
Structure Cell Type Level Pattern Image Note
TS28: pancreas type B pancreatic cell Present 2B CTRL Expression in beta-cells.
Specimen 2B M15betaKO Ins: postnatal week 8; Ins1tm1.1(cre)Thor/Ins1+, Med15tm1c(KOMP)Wtsi/Med15tm1c(KOMP)Wtsi (more )
Note: Conditional mutant. Double labeled: red - Ins2 and Ins1; green - Med15 (assay MGI:8166933).
Structure Cell Type Level Pattern Image Note
TS28: pancreas type B pancreatic cell Present 2B M15betaKO Expression in beta-cells.
Specimen S3E CTRL Ins: postnatal week 8; Ins1tm1.1(cre)Thor/Ins1+ (more )
Note: Double labeled: green - Ins2 and Ins1; red - EdU.
Structure Cell Type Level Pattern Image Note
TS28: pancreas type B pancreatic cell Present S3E CTRL
Specimen S3E M15beta ins: postnatal week 8; Ins1tm1.1(cre)Thor/Ins1+, Med15tm1c(KOMP)Wtsi/Med15tm1c(KOMP)Wtsi (more )
Note: Conditional mutant. Double labeled: green - Ins2 and Ins1; red - EdU.
Structure Cell Type Level Pattern Image Note
TS28: pancreas type B pancreatic cell Present S3E M15betaKO Authors report significant increase in beta-cell proliferation.
Specimen S3F CTRL Ins: postnatal week 8; Ins1tm1.1(cre)Thor/Ins1+ (more )
Note: Double labeled: green - Ins2 and Ins1; red - Gcg (assay MGI:8166935).
Structure Level Pattern Image Note
TS28: pancreas Present S3F CTRL
Specimen S3F M15beta Ins: postnatal week 8; Ins1tm1.1(cre)Thor/Ins1+, Med15tm1c(KOMP)Wtsi/Med15tm1c(KOMP)Wtsi (more )
Note: Conditional mutant. Double labeled: green - Ins2 and Ins1; red - Gcg (assay MGI:8166935).
Structure Level Pattern Image Note
TS28: pancreas Present S3F M15betaKO
Specimen 3B CTRL (left) Ins: postnatal week 8; Ins1tm1.1(cre)Thor/Ins1+ (more )
Note: Double labeled: red - Ins2 and Ins1; green - Mafa (assay MGI:8166936).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present 3B CTRL (left)
Specimen 3B M15beta (left) Ins: postnatal week 8; Ins1tm1.1(cre)Thor/Ins1+, Med15tm1c(KOMP)Wtsi/Med15tm1c(KOMP)Wtsi (more )
Note: Conditional mutant. Double labeled: red - Ins2 and Ins1; green - Mafa (assay MGI:8166936).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present 3B M15betaKO (left)
Specimen 3B CTRL (middle) Ins: postnatal week 8; Ins1tm1.1(cre)Thor/Ins1+ (more )
Note: Double labeled: red - Ins2 and Ins1; green - Ucn3 (assay MGI:8166937).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present 3B CTRL (middle)
Specimen 3B M15beta (middle) Ins: postnatal week 8; Ins1tm1.1(cre)Thor/Ins1+, Med15tm1c(KOMP)Wtsi/Med15tm1c(KOMP)Wtsi (more )
Note: Conditional mutant. Double labeled: red - Ins2 and Ins1; green - Ucn3 (assay MGI:8166937).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present 3B M15betaKO (middle)
Specimen S4B P1 CTRL Ins: postnatal day 1; Ins1tm1.1(cre)Thor/Ins1+ (more )
Note: Double labeled: red - Ins2 and Ins1; green - Ucn3 (assay MGI:8166937).
Structure Level Pattern Image Note
TS27: islets of Langerhans Present S4B P1 CTRL
Specimen S4B P1 M15beta Ins: postnatal day 1; Ins1tm1.1(cre)Thor/Ins1+, Med15tm1c(KOMP)Wtsi/Med15tm1c(KOMP)Wtsi (more )
Note: Conditional mutant. Double labeled: red - Ins2 and Ins1; green - Ucn3 (assay MGI:8166937).
Structure Level Pattern Image Note
TS27: islets of Langerhans Present S4B P1 M15betaKO
Specimen S4B P7 CTRL Ins: postnatal day 7; Ins1tm1.1(cre)Thor/Ins1+ (more )
Note: Double labeled: red - Ins2 and Ins1; green - Ucn3 (assay MGI:8166937).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present S4B P7 CTRL
Specimen S4B P7 M15beta Ins: postnatal day 7; Ins1tm1.1(cre)Thor/Ins1+, Med15tm1c(KOMP)Wtsi/Med15tm1c(KOMP)Wtsi (more )
Note: Conditional mutant. Double labeled: red - Ins2 and Ins1; green - Ucn3 (assay MGI:8166937).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present S4B P7 M15betaKO
Specimen S4B P14 CTRL Ins: postnatal day 14; Ins1tm1.1(cre)Thor/Ins1+ (more )
Note: Double labeled: red - Ins2 and Ins1; green - Ucn3 (assay MGI:8166937).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present S4B P14 CTRL
Specimen S4B P14 M15beta Ins: postnatal day 14; Ins1tm1.1(cre)Thor/Ins1+, Med15tm1c(KOMP)Wtsi/Med15tm1c(KOMP)Wtsi (more )
Note: Conditional mutant. Double labeled: red - Ins2 and Ins1; green - Ucn3 (assay MGI:8166937).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present S4B P14 M15betaKO
Specimen S4B 3wk CTRL Ins: postnatal week 3; Ins1tm1.1(cre)Thor/Ins1+ (more )
Note: Double labeled: red - Ins2 and Ins1; green - Ucn3 (assay MGI:8166937).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present S4B 3wk CTRL
Specimen S4B 3wk M15beta Ins: postnatal week 3; Ins1tm1.1(cre)Thor/Ins1+, Med15tm1c(KOMP)Wtsi/Med15tm1c(KOMP)Wtsi (more )
Note: Conditional mutant. Double labeled: red - Ins2 and Ins1; green - Ucn3 (assay MGI:8166937).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present S4B 3wk M15betaKO
Specimen S4B 4wk CTRL Ins: postnatal week 4; Ins1tm1.1(cre)Thor/Ins1+ (more )
Note: Double labeled: red - Ins2 and Ins1; green - Ucn3 (assay MGI:8166937).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present S4B 4wk CTRL
Specimen S4B 4wk M15beta Ins: postnatal week 4; Ins1tm1.1(cre)Thor/Ins1+, Med15tm1c(KOMP)Wtsi/Med15tm1c(KOMP)Wtsi (more )
Note: Conditional mutant. Double labeled: red - Ins2 and Ins1; green - Ucn3 (assay MGI:8166937).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present S4B 4wk M15betaKO
Specimen S4C P1 CTRL Ins: postnatal day 1; Ins1tm1.1(cre)Thor/Ins1+ (more )
Note: Double labeled: red - Ins2 and Ins1; green - Mafa (assay MGI:8166936).
Structure Level Pattern Image Note
TS27: islets of Langerhans Present S4C P1 CTRL
Specimen S4C P1 M15beta Ins: postnatal day 1; Ins1tm1.1(cre)Thor/Ins1+, Med15tm1c(KOMP)Wtsi/Med15tm1c(KOMP)Wtsi (more )
Note: Conditional mutant. Double labeled: red - Ins2 and Ins1; green - Mafa (assay MGI:8166936).
Structure Level Pattern Image Note
TS27: islets of Langerhans Present S4C P1 M15betaKO
Specimen S4C P7 CTRL Ins: postnatal day 7; Ins1tm1.1(cre)Thor/Ins1+ (more )
Note: Double labeled: red - Ins2 and Ins1; green - Mafa (assay MGI:8166936).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present S4C P7 CTRL
Specimen S4C P7 M15beta Ins: postnatal day 7; Ins1tm1.1(cre)Thor/Ins1+, Med15tm1c(KOMP)Wtsi/Med15tm1c(KOMP)Wtsi (more )
Note: Conditional mutant. Double labeled: red - Ins2 and Ins1; green - Mafa (assay MGI:8166936).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present S4C P7 M15betaKO
Specimen S4C P14 CTRL Ins: postnatal day 14; Ins1tm1.1(cre)Thor/Ins1+ (more )
Note: Double labeled: red - Ins2 and Ins1; green - Mafa (assay MGI:8166936).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present S4C P14 CTRL
Specimen S4C P14 M15beta Ins: postnatal day 14; Ins1tm1.1(cre)Thor/Ins1+, Med15tm1c(KOMP)Wtsi/Med15tm1c(KOMP)Wtsi (more )
Note: Conditional mutant. Double labeled: red - Ins2 and Ins1.
Structure Level Pattern Image Note
TS28: islets of Langerhans Present S4C P14 M15betaKO
Specimen S4C 3wk CTRL Ins: postnatal week 3; Ins1tm1.1(cre)Thor/Ins1+ (more )
Note: Double labeled: red - Ins2 and Ins1; green - Mafa (assay MGI:8166936).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present S4C 3wk CTRL
Specimen S4C 3wk M15beta Ins: postnatal week 3; Ins1tm1.1(cre)Thor/Ins1+, Med15tm1c(KOMP)Wtsi/Med15tm1c(KOMP)Wtsi (more )
Note: Conditional mutant. Double labeled: red - Ins2 and Ins1; green - Mafa (assay MGI:8166936).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present S4C 3wk M15betaKO
Specimen S4C 4wk CTRL Ins: postnatal week 4; Ins1tm1.1(cre)Thor/Ins1+ (more )
Note: Double labeled: red - Ins2 and Ins1; green - Mafa (assay MGI:8166936).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present S4C 4wk CTRL
Specimen S4C 4wk M15beta Ins: postnatal week 4; Ins1tm1.1(cre)Thor/Ins1+, Med15tm1c(KOMP)Wtsi/Med15tm1c(KOMP)Wtsi (more )
Note: Conditional mutant. Double labeled: red - Ins2 and Ins1; green - Mafa (assay MGI:8166936).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present S4C 4wk M15betaKO
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10/06/2026
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