Mafa Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:355262 Kadhim AZ, et al., Transcriptional coactivator MED15 is required for beta cell maturation. Nat Commun. 2024 Oct 8;15(1):8711
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:8166936
Gene symbol:	Mafa
Gene name:	MAF bZIP transcription factor A

Antibody:

anti-Mafa

Results

3B CTRL (left) ©

Specimen 3B CTRL Mafa: postnatal week 8; Ins1^{tm1.1(cre)Thor}/Ins1⁺ (more

)
Note: Double labeled: green - Mafa; red - Ins1 (assay MGI:8166934) and Ins2 (assay MGI:8166967).

Structure	Cell Type	Level	Pattern	Image	Note
TS28: islets of Langerhans	type B pancreatic cell	Present		3B CTRL (left)	Expression in beta-cells.

3B M15betaKO (left) ©

Specimen 3B M15beta Mafa: postnatal week 8; Ins1^{tm1.1(cre)Thor}/Ins1⁺, Med15^{tm1c(KOMP)Wtsi}/Med15^{tm1c(KOMP)Wtsi} (more

)
Note: Conditional mutant. Double labeled: green - Mafa; red - Ins1 (assay MGI:8166934) and Ins2 (assay MGI:8166967).

Structure	Level	Pattern	Image	Note
TS28: islets of Langerhans	Absent		3B M15betaKO (left)	Complete loss of expression.

S4C P1 CTRL ©

Specimen S4C P1 CTRL Mafa: postnatal day 1; Ins1^{tm1.1(cre)Thor}/Ins1⁺ (more

)
Note: Double labeled: green - Mafa; red - Ins1 (assay MGI:8166934) and Ins2 (assay MGI:8166967).

Structure	Level	Pattern	Image	Note
TS27: islets of Langerhans	Present		S4C P1 CTRL	Expression in beta-cells.

S4C P1 M15betaKO ©

Specimen S4C P1 M15beta Mafa: postnatal day 1; Ins1^{tm1.1(cre)Thor}/Ins1⁺, Med15^{tm1c(KOMP)Wtsi}/Med15^{tm1c(KOMP)Wtsi} (more

)
Note: Conditional mutant. Double labeled: green - Mafa; red - Ins1 (assay MGI:8166934) and Ins2 (assay MGI:8166967).

Structure	Level	Pattern	Image	Note
TS27: islets of Langerhans	Absent		S4C P1 M15betaKO	Complete loss of expression.

S4C P7 CTRL ©

Specimen S4C P7 CTRL Mafa: postnatal day 7; Ins1^{tm1.1(cre)Thor}/Ins1⁺ (more

)
Note: Double labeled: green - Mafa; red - Ins1 (assay MGI:8166934) and Ins2 (assay MGI:8166967).

Structure	Cell Type	Level	Pattern	Image	Note
TS28: islets of Langerhans	type B pancreatic cell	Present		S4C P7 CTRL	Expression in beta-cells.

S4C P7 M15betaKO ©

Specimen S4C P7 M15beta Mafa: postnatal day 7; Ins1^{tm1.1(cre)Thor}/Ins1⁺, Med15^{tm1c(KOMP)Wtsi}/Med15^{tm1c(KOMP)Wtsi} (more

)
Note: Conditional mutant. Double labeled: green - Mafa; red - Ins1 (assay MGI:8166934) and Ins2 (assay MGI:8166967).

Structure	Level	Pattern	Image	Note
TS28: islets of Langerhans	Absent		S4C P7 M15betaKO	Complete loss of expression.

S4C P14 CTRL ©

Specimen S4C P14 CTRL Mafa: postnatal day 14; Ins1^{tm1.1(cre)Thor}/Ins1⁺ (more

)
Note: Double labeled: green - Mafa; red - Ins1 (assay MGI:8166934) and Ins2 (assay MGI:8166967).

Structure	Cell Type	Level	Pattern	Image	Note
TS28: islets of Langerhans	type B pancreatic cell	Present		S4C P14 CTRL	Expression in beta-cells.

S4C P14 M15betaKO ©

Specimen S4C P14 M15beta Mafa: postnatal day 14; Ins1^{tm1.1(cre)Thor}/Ins1⁺, Med15^{tm1c(KOMP)Wtsi}/Med15^{tm1c(KOMP)Wtsi} (more

)
Note: Conditional mutant. Double labeled: green - Mafa; red - Ins1 (assay MGI:8166934) and Ins2 (assay MGI:8166967).

Structure	Level	Pattern	Image	Note
TS28: islets of Langerhans	Absent		S4C P14 M15betaKO	Complete loss of expression.

S4C 3wk CTRL ©

Specimen S4C 3wk CTRLMafa: postnatal week 3; Ins1^{tm1.1(cre)Thor}/Ins1⁺ (more

)
Note: Double labeled: green - Mafa; red - Ins1 (assay MGI:8166934) and Ins2 (assay MGI:8166967).

Structure	Cell Type	Level	Pattern	Image	Note
TS28: islets of Langerhans	type B pancreatic cell	Present		S4C 3wk CTRL	Expression in beta-cells.

Specimen S4C 3wk M15beta Mafa: postnatal week 3; Ins1^{tm1.1(cre)Thor}/Ins1⁺, Med15^{tm1c(KOMP)Wtsi}/Med15^{tm1c(KOMP)Wtsi} (more

)
Note: Conditional mutant. Double labeled: green - Mafa; red - Ins1 (assay MGI:8166934) and Ins2 (assay MGI:8166967).

Structure	Level	Pattern	Image	Note
TS28: islets of Langerhans	Absent		S4C 3wk M15betaKO	Complete loss of expression.

S4C 4wk CTRL ©

Specimen S4C 4wk CTRL Mafa: postnatal week 4; Ins1^{tm1.1(cre)Thor}/Ins1⁺ (more

)
Note: Double labeled: green - Mafa; red - Ins1 (assay MGI:8166934) and Ins2 (assay MGI:8166967).

Structure	Cell Type	Level	Pattern	Image	Note
TS28: islets of Langerhans	type B pancreatic cell	Present		S4C 4wk CTRL

Specimen S4C 4wk M15beta Mafa: postnatal week 4; Ins1^{tm1.1(cre)Thor}/Ins1⁺, Med15^{tm1c(KOMP)Wtsi}/Med15^{tm1c(KOMP)Wtsi} (more

)
Note: Conditional mutant. Double labeled: green - Mafa; red - Ins1 (assay MGI:8166934) and Ins2 (assay MGI:8166967).

Structure	Level	Pattern	Image	Note
TS28: islets of Langerhans	Absent		S4C 4wk M15betaKO	Complete loss of expression.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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