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Ins1tm1.1(cre)Thor
Targeted Allele Detail
Summary
Symbol: Ins1tm1.1(cre)Thor
Name: insulin I; targeted mutation 1.1, Bernard Thorens
MGI ID: MGI:5614359
Synonyms: Ins1Cre
Gene: Ins1  Location: Chr19:52252735-52253453 bp, + strand  Genetic Position: Chr19, 46.76 cM
Alliance: Ins1tm1.1(cre)Thor page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:217521
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Ins1tm1.1(cre)Thor expression driven by 1 gene
 
Mutation detailsA targeting construct was designed to insert a cre recombinase gene at the initiation codon of the gene with followed by a FRT-flanked neomycin resistance (neo) cassette, replacing the coding sequence. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:217521)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ins1 (mouse)
Summary of all recombinase alleles driven by Ins1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
1 RNA-Seq or microarray experiment(s)
Tumor Data
List all tumor models in MMHCdb carrying Ins1tm1.1(cre)Thor
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Ins1 Mutation:  46 strains or lines available
References
Original:  J:217521 Thorens B, et al., Ins1(Cre) knock-in mice for beta cell-specific gene recombination. Diabetologia. 2015 Mar;58(3):558-65
All:  69 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory