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Tet2 Gene Detail
Summary
  • Symbol
    Tet2
  • Name
    tet methylcytosine dioxygenase 2
  • Synonyms
    Ayu17-449, E130014J05Rik, mKIAA1546
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443298
    NCBI Gene: 214133
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:133169438-133250882 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 61.84 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1962 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443298
 protein coding gene Chr3:133169438-133250900 (-)
129S1/SvImJ ENSMUSG00200003656
 protein coding gene Chr3:129945601-130027070 (-)
A/J ENSMUSG00195008182
 protein coding gene Chr3:130051343-130132815 (-)
AKR/J ENSMUSG00220022154
 protein coding gene Chr3:128491730-128573202 (-)
BALB/cJ ENSMUSG00180003694
 protein coding gene Chr3:129980228-130061702 (-)
C3H/HeJ ENSMUSG00175013746
 protein coding gene Chr3:129553930-129635397 (-)
C57BL/6NJ ENSMUSG00215018391
 protein coding gene Chr3:130325566-130407026 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025651
 protein coding gene Chr3:126867018-126949289 (-)
CAST/EiJ ENSTCUG00005003603
 protein coding gene Chr3:130664453-130744739 (-)
CBA/J ENSMUSG00210004040
 protein coding gene Chr3:130171711-130253172 (-)
DBA/2J ENSMUSG00185026220
 protein coding gene Chr3:130789451-130870908 (-)
FVB/NJ ENSMUSG00205022419
 protein coding gene Chr3:129110721-129192190 (-)
JF1/MsJ ENSUMUG00000015421
 protein coding gene Chr3:129545738-129625883 (-)
LP/J ENSMUSG00230003031
 protein coding gene Chr3:132763996-132845459 (-)
NOD/ShiLtJ ENSMUSG00190001345
 protein coding gene Chr3:131168371-131249834 (-)
NZO/HlLtJ ENSMUSG00225004586
 protein coding gene Chr3:135212409-135289667 (-)
PWK/PhJ ENSLUMG00010015281
 protein coding gene Chr3:129519143-129599332 (-)
SPRET/EiJ ENSMSPG00010011833
 protein coding gene Chr3:130575243-130621446 (-)
WSB/EiJ ENSIUOG00005016819
 protein coding gene Chr3:130308416-130389896 (-)



Homology
more
  • Human Ortholog
    TET2, tet methylcytosine dioxygenase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TET2, tet methylcytosine dioxygenase 2
  • Synonyms
    IMD75, KIAA1546, MDS
  • Links
    NCBI Gene ID: 54790
    UniProt: Q6N021

  • Chr Location
    4q24; chr4:105145875-105279816 (+)  GRCh38
Human Diseases
more
  • Diseases
    10 with human TET2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
 View 1 model
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 6 alleles in 7 genetic backgrounds
    22 phenotypes from multigenic genotypes
    263 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele die shortly after birth and exhibit a loss of acidic granules in the proximal convoluted tubules of the kidneys. Mice homozygous for a conditional allele activated in hematopoeitic compartment exhibit self-renewal and myeloid transformation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    816
  • Tissues
    156
  • cDNA Data
    37
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 214133 NCBI Gene Model | MGI Sequence Detail 81445 C57BL/6J ±  kb
    transcript NM_001346736 RefSeq | MGI Sequence Detail 9205 C57BL/6  
    polypeptide Q4JK59 UniProt | EBI | MGI Sequence Detail 1912 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 38
      Primer pair 8
      Other 1
      Antibodies 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 384
      Developmental Gene Expression 28
      Diseases 2
      Gene Ontology 22
      Phenotypes 263
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:391221 Rondeau V, et al., Response to Immune Checkpoint Blockade Is Enhanced in the Presence of Hematopoietic TET2 Inactivation. Cancer Res. 2026 Feb 16;86(4):845-857
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory