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Dis3l2 Gene Detail
Summary
  • Symbol
    Dis3l2
  • Name
    DIS3 like 3'-5' exoribonuclease 2
  • Synonyms
    4930429A22Rik, 8030493P09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442555
    NCBI Gene: 208718
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:86631530-86977817 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 43.99 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    5341 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442555
 protein coding gene Chr1:86629646-86977819 (+)
129S1/SvImJ ENSMUSG00200036715
 protein coding gene Chr1:83870375-84223175 (+)
A/J ENSMUSG00195030276
 protein coding gene Chr1:83430839-83783649 (+)
AKR/J ENSMUSG00220037711
 protein coding gene Chr1:83549189-83902229 (+)
BALB/cJ ENSMUSG00180015655
 protein coding gene Chr1:83718709-84071718 (+)
C3H/HeJ ENSMUSG00175001239
 protein coding gene Chr1:83605288-83958050 (+)
C57BL/6NJ ENSMUSG00215024833
 protein coding gene Chr1:83520583-83873607 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014369
 protein coding gene Chr1:79211461-79540115 (+)
CAST/EiJ ENSTCUG00005006768
 protein coding gene Chr1:83172047-83527673 (+)
CBA/J ENSMUSG00210011648
 protein coding gene Chr1:83443019-83795980 (+)
DBA/2J ENSMUSG00185016286
 protein coding gene Chr1:87915032-88267962 (+)
FVB/NJ ENSMUSG00205038031
 protein coding gene Chr1:82863624-83217679 (+)
JF1/MsJ ENSUMUG00000008423
 protein coding gene Chr1:86688218-87035985 (+)
LP/J ENSMUSG00230015047
 protein coding gene Chr1:87199956-87552745 (+)
NOD/ShiLtJ ENSMUSG00190022007
 protein coding gene Chr1:83498253-83851236 (+)
NZO/HlLtJ ENSMUSG00225004396
 protein coding gene Chr1:91102752-91455451 (+)
PWK/PhJ ENSLUMG00010036308
 protein coding gene Chr1:83069047-83418085 (+)
SPRET/EiJ ENSMSPG00010041487
 protein coding gene Chr1:85072555-85430610 (+)
WSB/EiJ ENSIUOG00005038527
 protein coding gene Chr1:83100513-83453357 (+)



Homology
more
  • Human Ortholog
    DIS3L2, DIS3 like 3'-5' exoribonuclease 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DIS3L2, DIS3 like 3'-5' exoribonuclease 2
  • Synonyms
    FAM6A, hDIS3L2, PRLMNS
  • Links
    NCBI Gene ID: 129563
    UniProt: Q8IYB7

  • Chr Location
    2q37.1; chr2:231961245-232344350 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dis3l2 mouse models; 2 with human DIS3L2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 5 alleles in 5 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null mice are perinatal lethal, exhibit respiratory failure upon caesarean delivery, and exhibit bradykinesia, abnormal spine curvature, and genitourinary abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    19
  • cDNA Data
    45
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053333 Ensembl Gene Model | MGI Sequence Detail 346288 C57BL/6J ±  kb
    transcript ENSMUST00000168237 Ensembl | MGI Sequence Detail 3154 Not Applicable  
    polypeptide ENSMUSP00000132673 Ensembl | MGI Sequence Detail 884 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 45
      Primer pair 1
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1924801
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 11
      Phenotypes 19
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:361537 Li N, et al., Conditional ablation of DIS3L2 ribonuclease in pre-meiotic germ cells causes defective spermatogenesis and infertility in male mice. Theranostics. 2024;14(14):5621-5642
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory