About   Help   FAQ
Dis3l2em1Jtm
Endonuclease-mediated Allele Detail
Summary
Symbol: Dis3l2em1Jtm
Name: DIS3 like 3'-5' exoribonuclease 2; endonuclease-mediated mutation 1, Joshua T Mendell
MGI ID: MGI:6286049
Synonyms: Dis3l1delta11
Gene: Dis3l2  Location: Chr1:86631530-86977817 bp, + strand  Genetic Position: Chr1, 43.99 cM
Alliance: Dis3l2em1Jtm page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR/Cas9 technology deleted exon 11 resulting in a frameshift and premature termination codon and a null allele. Western blot analysis confirmed absence of protein in kidneys. (J:272435)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 6 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dis3l2 Mutation:  43 strains or lines available
References
Original:  J:272435 Hunter RW, et al., Loss of Dis3l2 partially phenocopies Perlman syndrome in mice and results in up-regulation of Igf2 in nephron progenitor cells. Genes Dev. 2018 Jul 1;32(13-14):903-908
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
01/31/2023
MGI 6.22
The Jackson Laboratory