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Icos Gene Detail
Summary
  • Symbol
    Icos
  • Name
    inducible T cell co-stimulator
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858745
    NCBI Gene: 54167
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:61017086-61039479 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 30.60 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    144 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858745
 protein coding gene Chr1:60999909-61039481 (+)
129S1/SvImJ ENSMUSG00200018231
 protein coding gene Chr1:58517235-58539626 (+)
A/J ENSMUSG00195027548
 protein coding gene Chr1:58056584-58078982 (+)
AKR/J ENSMUSG00220034290
 protein coding gene Chr1:58137724-58160183 (+)
BALB/cJ ENSMUSG00180014163
 protein coding gene Chr1:58318045-58340499 (+)
C3H/HeJ ENSMUSG00175000984
 protein coding gene Chr1:58433906-58456302 (+)
C57BL/6NJ ENSMUSG00215030166
 protein coding gene Chr1:58365835-58388233 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014193
 protein coding gene Chr1:55095458-55120153 (+)
CAST/EiJ ENSTCUG00005012710
 protein coding gene Chr1:58198988-58222712 (+)
CBA/J ENSMUSG00210035107
 protein coding gene Chr1:58119602-58142000 (+)
DBA/2J ENSMUSG00185038750
 protein coding gene Chr1:59238651-59261056 (+)
FVB/NJ ENSMUSG00205020916
 protein coding gene Chr1:58071445-58093856 (+)
JF1/MsJ ENSUMUG00000036737
 protein coding gene Chr1:58198382-58222217 (+)
LP/J ENSMUSG00230026362
 protein coding gene Chr1:59239098-59261490 (+)
NOD/ShiLtJ ENSMUSG00190028624
 protein coding gene Chr1:58311033-58333480 (+)
NZO/HlLtJ ENSMUSG00225000739
 protein coding gene Chr1:62463134-62483162 (+)
PWK/PhJ ENSLUMG00010024969
 protein coding gene Chr1:57726759-57749231 (+)
SPRET/EiJ ENSMSPG00010023543
 protein coding gene Chr1:59675516-59696500 (+)
WSB/EiJ ENSIUOG00005019791
 protein coding gene Chr1:57901274-57923684 (+)



Homology
more
  • Human Ortholog
    ICOS, inducible T cell costimulator
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ICOS, inducible T cell costimulator
  • Synonyms
    AILIM, CD278, CVID1
  • Links
    NCBI Gene ID: 29851
    UniProt: Q9Y6W8

  • Chr Location
    2q33.2; chr2:203936763-203961577 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Icos mouse models; 3 with human ICOS associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    55 phenotypes from 7 alleles in 9 genetic backgrounds
    4 phenotypes from multigenic genotypes
    135 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene show reduced basal IgG1 levels and impaired interactions between T and B cells. T cell dependent B cell isotype switching was impaired as well.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    43
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026009 Ensembl Gene Model | MGI Sequence Detail 22394 C57BL/6J ±  kb
    transcript ENSMUST00000027162 Ensembl | MGI Sequence Detail 810 Not Applicable  
    polypeptide ENSMUSP00000027162 Ensembl | MGI Sequence Detail 223 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 43
      Primer pair 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 274
      Diseases 2
      Gene Ontology 13
      Phenotypes 135
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:371160 Humblin E, et al., The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1(+)CD8(+) T cells. Immunity. 2025 Aug 12;58(8):1966-1983.e10
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory