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Polg Gene Detail
Summary
  • Symbol
    Polg
  • Name
    polymerase (DNA directed), gamma
  • Synonyms
    mitochondrial DNA polymerase gamma, mitochondrial DNA polymerase-gamma, Polga, Pol gamma, polymerase gamma
Location &
Maps
more
  • Sequence Map
    Chr7:79095979-79116110 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.04 cM, cytoband E
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    506 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196389
 protein coding gene Chr7:79095979-79117659 (-)
129S1/SvImJ ENSMUSG00200034576
 protein coding gene Chr7:65909148-65928055 (-)
A/J ENSMUSG00195013608
 protein coding gene Chr7:70324665-70343804 (-)
AKR/J ENSMUSG00220036682
 protein coding gene Chr7:63866683-63885822 (-)
BALB/cJ ENSMUSG00180013122
 protein coding gene Chr7:67049776-67068916 (-)
C3H/HeJ ENSMUSG00175020848
 protein coding gene Chr7:67821220-67840127 (-)
C57BL/6NJ ENSMUSG00215017344
 protein coding gene Chr7:66920776-66939917 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029880
 protein coding gene Chr7:81999048-82019328 (-)
CAST/EiJ ENSTCUG00005004099
 protein coding gene Chr7:70372462-70391393 (-)
CBA/J ENSMUSG00210023850
 protein coding gene Chr7:67672511-67691418 (-)
DBA/2J ENSMUSG00185045173
 protein coding gene Chr7:71995238-72014145 (-)
FVB/NJ ENSMUSG00205014117
 protein coding gene Chr7:67561668-67580812 (-)
JF1/MsJ ENSUMUG00000014365
 protein coding gene Chr7:76656081-76675023 (-)
LP/J ENSMUSG00230011304
 protein coding gene Chr7:78085445-78104585 (-)
NOD/ShiLtJ ENSMUSG00190018435
 protein coding gene Chr7:67814382-67833522 (-)
NZO/HlLtJ ENSMUSG00225041336
 protein coding gene Chr7:76327014-76346164 (-)
PWK/PhJ ENSLUMG00010016784
 protein coding gene Chr7:66243331-66262474 (-)
SPRET/EiJ ENSMSPG00010022215
 protein coding gene Chr7:66665634-66681416 (-)
WSB/EiJ ENSIUOG00005020758
 protein coding gene Chr7:68163187-68182112 (-)



Homology
more
  • Human Ortholog
    POLG, DNA polymerase gamma, catalytic subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLG, DNA polymerase gamma, catalytic subunit
  • Synonyms
    MIRAS, MTDPS4A, MTDPS4B, PEO, POLG1, POLGA, PolG-alpha, SANDO, SCAE
  • Links
    NCBI Gene ID: 5428
    UniProt: P54098

  • Chr Location
    15q26.1; chr15:89305198-89334861 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with Polg mouse models; 15 with human POLG associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
      
IDs
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    87 phenotypes from 6 alleles in 7 genetic backgrounds
    4 images
    120 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous proof-reading deficient mutants display reduced life spans and premature aging with weight loss, decreased subcutaneous fat, alopecia, kyphosis, osteoporosis, anemia, reduced fertility, and enlarged hearts. Homozygous null mice display embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    618
  • Tissues
    14
  • cDNA Data
    14
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039176 Ensembl Gene Model | MGI Sequence Detail 20132 C57BL/6J ±  kb
    transcript ENSMUST00000073889 Ensembl | MGI Sequence Detail 7837 Not Applicable  
    polypeptide ENSMUSP00000073551 Ensembl | MGI Sequence Detail 1217 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 1
      cDNA 14
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2141822
    References
    more
    • Summaries
      All 179
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 19
      Phenotypes 120
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:385579 Wu Y, et al., Periosteal mitochondria DNA structures drive aging-associated poor skeletal repair. Bone Res. 2026 Apr 7;14(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory