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Adipoq Gene Detail
Summary
  • Symbol
    Adipoq
  • Name
    adiponectin, C1Q and collagen domain containing
  • Synonyms
    Acdc, Acrp30, Ad, adipo, adiponectin, apM1, APN, GBP28
  • Feature Type
    protein coding gene
  • IDs
    MGI:106675
    NCBI Gene: 11450
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
  • Regulated by
    Rr608 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr16:22965286-22976718 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 13.96 cM, cytoband B3-B4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    414 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106675
 protein coding gene Chr16:22965286-22976778 (+)
129S1/SvImJ ENSMUSG00200040742
 protein coding gene Chr16:19969128-19980624 (+)
A/J ENSMUSG00195028533
 protein coding gene Chr16:19523623-19535123 (+)
AKR/J ENSMUSG00220043597
 protein coding gene Chr16:19843050-19854554 (+)
BALB/cJ ENSMUSG00180037758
 protein coding gene Chr16:19764232-19775720 (+)
C3H/HeJ ENSMUSG00175048274
 protein coding gene Chr16:19909143-19920635 (+)
C57BL/6NJ ENSMUSG00215038663
 protein coding gene Chr16:19636345-19647841 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020614
 protein coding gene Chr16:20350619-20363674 (+)
CAST/EiJ ENSTCUG00005035352
 protein coding gene Chr16:20239003-20251318 (+)
CBA/J ENSMUSG00210040678
 protein coding gene Chr16:19930831-19942323 (+)
DBA/2J ENSMUSG00185031158
 protein coding gene Chr16:19869620-19881118 (+)
FVB/NJ ENSMUSG00205041067
 protein coding gene Chr16:19870283-19881783 (+)
JF1/MsJ ENSUMUG00000034881
 protein coding gene Chr16:20091557-20103867 (+)
LP/J ENSMUSG00230029465
 protein coding gene Chr16:22448641-22460133 (+)
NOD/ShiLtJ ENSMUSG00190032012
 protein coding gene Chr16:20011028-20022522 (+)
NZO/HlLtJ ENSMUSG00225035977
 protein coding gene Chr16:25699774-25711266 (+)
PWK/PhJ ENSLUMG00010048629
 protein coding gene Chr16:19914365-19926521 (+)
SPRET/EiJ ENSMSPG00010042093
 protein coding gene Chr16:19796297-19807782 (+)
WSB/EiJ ENSIUOG00005036393
 protein coding gene Chr16:20115463-20126942 (+)



Homology
more
  • Human Ortholog
    ADIPOQ, adiponectin, C1Q and collagen domain containing
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADIPOQ, adiponectin, C1Q and collagen domain containing
  • Synonyms
    ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28
  • Links
    NCBI Gene ID: 9370
    UniProt: Q15848

  • Chr Location
    3q27.3; chr3:186842704-186858463 (+)  GRCh38
Human Diseases
more
  • Diseases
    11 with human ADIPOQ associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    90 phenotypes from 7 alleles in 12 genetic backgrounds
    42 phenotypes from multigenic genotypes
    2 images
    292 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit increased beta-oxidation in muscle and liver, impaired free fatty acid clearance, and moderate insulin resistance. Heterozygotes show mild insulin resistance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    159
  • GO References
    41
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    684
  • Tissues
    48
  • cDNA Data
    72
  • Literature Summary
    43
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11450 NCBI Gene Model | MGI Sequence Detail 11433 C57BL/6J ±  kb
    transcript NM_009605 RefSeq | MGI Sequence Detail 1232 ZRU/MplStud  
    polypeptide Q60994 UniProt | EBI | MGI Sequence Detail 247 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 81
      Genomic 1
      cDNA 74
      Primer pair 6
      Antibodies 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35134
    References
    more
    • Summaries
      All 572
      Developmental Gene Expression 43
      Gene Ontology 41
      Phenotypes 292
    • Earliest
      J:32963 Scherer PE, et al., A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem. 1995 Nov 10;270(45):26746-9
    • Latest
      J:391249 Zhou HY, et al., A skin-hypothalamus axis couples heat stress and metabolic dysfunction. Cell. 2026 Apr 21;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory