Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng
involves: 129X1/SvJ
|
no abnormal phenotype detected |
J:180304
|
Runx2em1(IMPC)Rbrc/Runx2+
C57BL/6NJcl-Runx2em1(IMPC)Rbrc/Rbrc
|
abnormal bone structure |
J:211773
|
|
abnormal clavicle morphology |
J:211773
|
|
abnormal cranium morphology |
J:211773
|
|
abnormal humerus morphology |
J:211773
|
|
abnormal pelvic girdle bone morphology |
J:211773
|
|
abnormal vertebrae morphology |
J:211773
|
|
abnormal vertebral arch morphology |
J:211773
|
|
abnormal zygomatic bone morphology |
J:211773
|
|
decreased bone mineral content |
J:211773
|
|
increased lean body mass |
J:211773
|
Runx2tm1.1Hkiy/Runx2tm1.1Hkiy
involves: 129P2/OlaHsd * C57BL/6
|
normal
mortality/aging |
J:223410
|
Runx2tm1.1Jals/Runx2tm1.1Jals
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
|
normal
skeleton phenotype |
J:143532
|
Runx2tm1.1Yyon/Runx2tm1.1Yyon
Tg(Col1a1-cre)1Kry/0
involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N
|
normal
mortality/aging |
J:210124
|
|
normal
skeleton phenotype |
J:210124
|
Runx2tm1.1Yyon/Runx2tm1.1Yyon
Tg(Col2a1-cre)1Star/0
involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
|
delayed bone ossification |
J:210124
|
|
delayed endochondral bone ossification |
J:210124
|
|
neonatal lethality, complete penetrance |
J:210124
|
|
respiratory distress |
J:210124
|
Runx2tm1Gss/Runx2+
involves: 129S7/SvEvBrd
|
abnormal neurocranium morphology |
J:143532
|
|
absent clavicle |
J:143532
|
Runx2tm1Gss/Runx2+
involves: 129S7/SvEvBrd * C57BL/6
|
absent clavicle |
J:70461
|
|
decreased body weight |
J:70461
|
|
normal
skeleton phenotype |
J:70461
|
|
slow postnatal weight gain |
J:70461
|
Runx2tm1Gss/Runx2tm1Gss
involves: 129S7/SvEvBrd * C57BL/6
|
abnormal bone mineralization |
J:70461
|
|
abnormal bone ossification |
J:70461
|
|
abnormal cartilage development |
J:70461
|
|
abnormal craniofacial bone morphology |
J:70461
|
|
abnormal limb development |
J:70461
|
|
abnormal vascular development |
J:70461
|
|
lethality throughout fetal growth and development, complete penetrance |
J:70461
|
Runx2tm1Hkiy/Runx2+
involves: 129P2/OlaHsd * C57BL/6
|
delayed endochondral bone ossification |
J:223410
|
|
delayed intramembranous bone ossification |
J:223410
|
|
impaired osteoblast differentiation |
J:223410
|
|
small clavicle |
J:223410
|
Runx2tm1Hkiy/Runx2tm1Hkiy
involves: 129P2/OlaHsd * C57BL/6
|
abnormal hyoid bone morphology |
J:223410
|
|
abnormal neurocranium morphology |
J:223410
|
|
abnormal phalanx morphology |
J:223410
|
|
abnormal skeleton development |
J:223410
|
|
absent clavicle |
J:223410
|
|
absent occipital bone |
J:223410
|
|
decreased bone mass |
J:223410
|
|
decreased bone mineral density of femur |
J:223410
|
|
decreased bone trabecula number |
J:223410
|
|
decreased bone volume |
J:223410
|
|
decreased trabecular bone thickness |
J:223410
|
|
decreased volumetric bone mineral density |
J:223410
|
|
delayed bone ossification |
J:223410
|
|
delayed endochondral bone ossification |
J:223410
|
|
delayed intramembranous bone ossification |
J:223410
|
|
delayed sagittal suture closure |
J:223410
|
|
impaired osteoblast differentiation |
J:223410
|
|
increased bone trabecular spacing |
J:223410
|
|
neonatal lethality, complete penetrance |
J:223410
|
Runx2tm1Jals/Runx2+
involves: 129S7/SvEvBrd * C57BL/6
|
normal
skeleton phenotype |
J:143532
|
Runx2tm1Jals/Runx2tm1Jals
involves: 129S7/SvEvBrd * C57BL/6
|
abnormal bone ossification |
J:143532
|
|
abnormal clavicle morphology |
J:143532
|
|
abnormal cranial suture morphology |
J:143532
|
|
abnormal neurocranium morphology |
J:143532
|
|
abnormal osteoblast differentiation |
J:143532
|
|
abnormal skeleton development |
J:143532
|
|
abnormal trabecular bone morphology |
J:143532
|
|
clavicle hypoplasia |
J:143532
|
|
increased osteoblast proliferation |
J:143532
|
|
normal
mortality/aging |
J:143532
|
|
small basisphenoid bone |
J:143532
|
|
wide cranial sutures |
J:143532
|
Runx2tm1Javed/Runx2tm1Javed
Tg(Col2a1-cre)1Bhr/0
involves: C57BL/6 * SJL
|
abnormal craniofacial bone morphology |
J:212896
|
|
abnormal limb bone morphology |
J:212896
|
|
abnormal long bone epiphyseal plate morphology |
J:212896
|
|
abnormal metatarsal bone morphology |
J:212896
|
|
abnormal pelvic girdle bone morphology |
J:212896
|
|
absent metacarpal bones |
J:212896
|
|
absent scapula |
J:212896
|
|
absent vertebrae |
J:212896
|
|
decreased birth body size |
J:212896
|
|
decreased birth weight |
J:212896
|
|
neonatal lethality, complete penetrance |
J:212896
|
|
respiratory failure |
J:212896
|
|
short ribs |
J:212896
|
Runx2tm1Kish/Runx2+
involves: 129P2/OlaHsd * C57BL/6
|
abnormal interparietal bone morphology |
J:40783
|
|
abnormal neurocranium morphology |
J:129364
|
|
abnormal parietal bone morphology |
J:40783
|
|
abnormal supraoccipital bone morphology |
J:40783
|
|
abnormal thyroid follicle morphology |
J:162258
|
|
abnormal thyroid gland morphology |
J:162258
|
|
clavicle hypoplasia |
J:40783,
J:129364
|
|
decreased activity of thyroid gland |
J:162258
|
|
decreased circulating thyroxine level |
J:162258
|
|
decreased thyroxine level |
J:162258
|
|
decreased triiodothyronine level |
J:162258
|
|
delayed fontanelle closure |
J:129364
|
|
enlarged thymus |
J:162258
|
|
normal
growth/size/body region phenotype |
J:40783
|
|
impaired adaptive thermogenesis |
J:162258
|
|
increased thyroid-stimulating hormone level |
J:162258
|
|
nasal bone hypoplasia |
J:40783
|
|
normal
skeleton phenotype |
J:40783
|
Runx2tm1Kish/Runx2tm1Kish
involves: 129P2/OlaHsd * C57BL/6
|
abnormal bone marrow cavity morphology |
J:40783,
J:53069
|
|
abnormal bone ossification |
J:40783,
J:59821
|
|
abnormal cartilage development |
J:54095
|
|
abnormal chondrocyte morphology |
J:59821
|
|
abnormal definitive hematopoiesis |
J:53069
|
|
abnormal dermal layer morphology |
J:40783
|
|
abnormal femur morphology |
J:40783
|
|
abnormal long bone epiphyseal ossification zone morphology |
J:40783,
J:54095
|
|
abnormal long bone epiphyseal plate morphology |
J:54095
|
|
abnormal long bone epiphyseal plate proliferative zone |
J:59821
|
|
abnormal neurocranium morphology |
J:40783,
J:59821
|
|
abnormal osteoblast differentiation |
J:40783,
J:59821
|
|
abnormal osteoclast differentiation |
J:40783,
J:59821
|
|
abnormal skeleton development |
J:40783
|
|
abnormal splenic cell ratio |
J:53069
|
|
abnormal tibia morphology |
J:40783,
J:59821
|
|
anemia |
J:53069
|
|
cyanosis |
J:40783
|
|
decreased B cell number |
J:53069
|
|
decreased body weight |
J:40783
|
|
decreased diameter of tibia |
J:59821
|
|
decreased thymocyte number |
J:40783
|
|
disproportionate dwarf |
J:40783
|
|
enlarged spleen |
J:53069
|
|
extramedullary hematopoiesis |
J:53069
|
|
increased granulocyte number |
J:53069
|
|
increased nucleated erythrocyte cell number |
J:53069
|
|
increased width of hypertrophic chondrocyte zone |
J:54095
|
|
liver hypoplasia |
J:53069
|
|
normal
muscle phenotype |
J:40783
|
|
neonatal lethality, complete penetrance |
J:40783
|
|
normal
nervous system phenotype |
J:40783
|
|
respiratory failure |
J:40783
|
|
short limbs |
J:40783
|
|
small liver |
J:53069
|
Runx2tm1Ldq/Runx2+
involves: C57BL/6J
|
abnormal tibia morphology |
J:89822
|
|
abnormal trabecular bone morphology |
J:89822
|
|
decreased birth body size |
J:89822
|
|
decreased birth weight |
J:89822
|
Runx2tm1Ldq/Runx2tm1Ldq
involves: C57BL/6J
|
abnormal bone ossification |
J:89822
|
|
abnormal clavicle morphology |
J:89822
|
|
abnormal cranium morphology |
J:89822
|
|
abnormal hyoid bone morphology |
J:89822
|
|
abnormal long bone epiphysis morphology |
J:89822
|
|
abnormal nasal bone morphology |
J:89822
|
|
abnormal phalanx morphology |
J:89822
|
|
abnormal rib morphology |
J:89822
|
|
abnormal skeleton morphology |
J:89822
|
|
abnormal tibia morphology |
J:89822
|
|
abnormal trabecular bone morphology |
J:89822
|
|
absent occipital bone |
J:89822
|
|
absent zygomatic arch |
J:89822
|
|
decreased birth body size |
J:89822
|
|
decreased birth weight |
J:89822
|
|
decreased compact bone thickness |
J:89822
|
|
decreased length of long bones |
J:89822
|
|
delayed bone ossification |
J:89822
|
|
large anterior fontanelle |
J:89822
|
|
postnatal lethality, incomplete penetrance |
J:89822
|
|
premature death |
J:89822
|
Runx2tm1Mjo/Runx2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
abnormal cartilage morphology |
J:40784
|
|
abnormal epidermis suprabasal layer morphology |
J:132568
|
|
abnormal fontanelle morphology |
J:40784
|
|
abnormal humerus morphology |
J:40784
|
|
abnormal long bone epiphyseal plate morphology |
J:40784
|
|
abnormal osteoblast differentiation |
J:40784
|
|
abnormal skin morphology |
J:132568
|
|
abnormal tooth development |
J:40784
|
|
abnormal xiphoid process morphology |
J:40784
|
|
absent deltoid tuberosity |
J:40784
|
|
clavicle hypoplasia |
J:40784
|
|
delayed endochondral bone ossification |
J:40784
|
|
delayed intramembranous bone ossification |
J:40784
|
|
hyoid bone hypoplasia |
J:40784
|
|
interparietal bone hypoplasia |
J:40784
|
|
ischium hypoplasia |
J:40784
|
|
parietal bone hypoplasia |
J:40784
|
|
pubis hypoplasia |
J:40784
|
|
thin epidermis |
J:132568
|
|
underdeveloped hair follicles |
J:132568
|
|
wide cranial sutures |
J:40784
|
Runx2tm1Mjo/Runx2+
Not Specified
|
abnormal fontanelle morphology |
J:167992
|
|
abnormal hyoid bone morphology |
J:167992
|
|
clavicle hypoplasia |
J:167992,
J:201597
|
Runx2tm1Mjo/Runx2tm1Mjo
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
abnormal bone ossification |
J:40784
|
|
abnormal cartilage development |
J:40784
|
|
abnormal clavicle morphology |
J:40784
|
|
abnormal cranium morphology |
J:40784
|
|
abnormal lung volume |
J:40784
|
|
abnormal nose morphology |
J:40784
|
|
abnormal tooth development |
J:40784
|
|
absent bone marrow cell |
J:40784
|
|
decreased body size |
J:40784
|
|
decreased body weight |
J:40784
|
|
decreased osteoblast cell number |
J:40784
|
|
delayed endochondral bone ossification |
J:40784
|
|
delayed intramembranous bone ossification |
J:40784
|
|
increased nucleated erythrocyte cell number |
J:40784
|
|
neonatal lethality, complete penetrance |
J:40784
|
|
pulmonary vascular congestion |
J:40784
|
|
respiratory failure |
J:40784
|
Runx2tm1Mjo/Runx2tm1Mjo
involves: C57BL/6 * NMRI
|
abnormal cervical loop morphology |
J:87161
|
|
abnormal dental lamina morphology |
J:87161
|
|
abnormal dental papilla morphology |
J:87161
|
|
abnormal enamel knot morphology |
J:87161
|
|
abnormal molar morphology |
J:87161
|
|
arrest of tooth development |
J:87161
|
|
cleft secondary palate |
J:87161
|
|
eyelids open at birth |
J:87161
|
|
growth retardation of incisors |
J:87161
|
|
growth retardation of molars |
J:87161
|
|
palatal shelves fail to meet at midline |
J:87161
|
Runx2tm1Mjo/Runx2tm1Mjo
Not Specified
|
abnormal cartilage development |
J:53540
|
|
abnormal chondrocyte morphology |
J:53540
|
|
abnormal dentin morphology |
J:54817
|
|
abnormal enamel morphology |
J:54817
|
|
abnormal humerus morphology |
J:53540
|
|
abnormal incisor morphology |
J:54817
|
|
abnormal long bone epiphyseal plate morphology |
J:53540
|
|
abnormal long bone hypertrophic chondrocyte zone |
J:158761
|
|
abnormal radius morphology |
J:53540
|
|
abnormal skeleton development |
J:158761
|
|
abnormal ulna morphology |
J:53540
|
|
abnormal xiphoid process morphology |
J:158761
|
|
decreased angiogenesis |
J:158761
|
|
delayed endochondral bone ossification |
J:53540
|
|
growth retardation of incisors |
J:54817
|
|
growth retardation of molars |
J:54817
|
|
small incisors |
J:54817
|
|
small molars |
J:54817
|
Tg(Col1a1-Runx2)#Pmt/0
involves: BALB/c * C57BL/6
|
abnormal bone mineralization |
J:167992
|
|
abnormal bone ossification |
J:167992
|
|
abnormal compact bone morphology |
J:167992
|
|
abnormal osteoblast differentiation |
J:167992
|
|
decreased bone mass |
J:167992
|
|
decreased compact bone thickness |
J:167992
|
|
decreased osteocyte number |
J:167992
|
|
fragile skeleton |
J:167992
|
|
increased osteoblast cell number |
J:167992
|
|
increased osteoclast cell number |
J:167992
|
Excel File
Analysis Tools