72 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Chd7Gt(XK403)Byg/Chd7+ Fgf8tm1.2Mrt/Fgf8+ either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)	abnormal fourth pharyngeal arch artery morphology	J:154590
Chd7Gt(XK403)Byg/Chd7+ Fgf8tm2Mrt/Fgf8+ involves: 129 * 129P2/OlaHsd * C57BL/6J * DBA/2J	abnormal inferior colliculus morphology	J:207892
	absent cerebellum vermis	J:207892
	small cerebellum	J:207892
Ctnnb1tm2Kem/Ctnnb1tm2Kem Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+ Tg(Msx2-cre)5Rem/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	abnormal autopod morphology	J:223057
	abnormal hindlimb morphology	J:223057
	abnormal ulna morphology	J:223057
	normal limbs/digits/tail phenotype	J:223057
Ctnnb1tm2Kem/Ctnnb1tm2Kem Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+ Shhtm1(EGFP/cre)Cjt/Shh+ involves: 129S1/Sv * 129X1/SvJ	abnormal reproductive system development	J:223057
	abnormal tail development	J:223057
	normal reproductive system phenotype	J:223057
Del(19Poll-Fbxw4)4Fsp/+ Fgf8tm1.4Mrt/Fgf8+ involves: 129P2/OlaHsd * 129S1/Sv	abnormal brain development	J:196292
	abnormal brain morphology	J:196292
	abnormal craniofacial morphology	J:196292
	absent forelimb	J:196292
	absent hindlimb	J:196292
	absent kidney	J:196292
	absent olfactory bulb	J:196292
	embryonic growth retardation	J:196292
	prenatal lethality, incomplete penetrance	J:196292
	short limbs	J:196292
En1tm7(cre/ESR1)Alj/0 Fgf8tm1.3Mrt/Fgf8tm2.1Jyhl Gt(ROSA)26Sortm1Sor/0 involves: 129P2/OlaHsd * 129S6/SvEvTac	normal growth/size/body region phenotype	J:156717
	normal nervous system phenotype	J:156717
Fgf8tm1.1Mrt/Fgf8tm1.4Mrt Foxg1tm1M/Foxg1+ involves: 129P2/OlaHsd	abnormal neuron apoptosis	J:111586
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor Nkx2-5tm1(cre)Rjs/Nkx2-5+ involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd	abnormal heart development	J:109474
	abnormal splanchnic mesoderm morphology	J:109474
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt Tg(CAG-Bgeo,-Fgf4)1Mrt/? Tg(Msx2-cre)5Rem/? involves: 129P2/OlaHsd	abnormal digit development	J:104411
	abnormal eyelid morphology	J:104411
	abnormal limb bud morphology	J:104411
	abnormal limb development	J:104411
	abnormal reproductive system morphology	J:104411
	fused tarsal bones	J:104411
	normal limbs/digits/tail phenotype	J:104411
	polysyndactyly	J:104411
	postnatal growth retardation	J:104411
Fgf8tm1.4Mrt/Fgf8+ Tfap2atm1Will/Tfap2atm2.1Will involves: 129P2/OlaHsd * 129S1/Sv * Black Swiss	abnormal midface morphology	J:217408
	abnormal nasal pit morphology	J:217408
	cleft primary palate	J:217408
	unilateral cleft palate	J:217408
Fgf8tm1.4Mrt/Fgf8+ Tbx1tm1Bld/Tbx1+ involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR	abnormal aortic arch development	J:78686
	abnormal aortic arch morphology	J:78686
	abnormal fourth pharyngeal arch artery morphology	J:78686
	cervical aortic arch	J:78686
	interrupted aortic arch, type b	J:78686
	right aortic arch	J:78686
	thymus hypoplasia	J:78686
Fgf8tm1.4Mrt/Fgf8+ Fgf17tm1Dor/Fgf17tm1Dor involves: 129P2/OlaHsd * 129S6/SvEvTac	abnormal cerebellum anterior vermis morphology	J:61429
	abnormal cerebellum vermis morphology	J:61429
	abnormal gait	J:61429
	abnormal Purkinje cell morphology	J:61429
	decreased inferior colliculus size	J:61429
Fgf8tm1.4Mrt/Fgf8+ Gli3tm1.1Alj/Gli3tm1.1Alj involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	absent inferior colliculus	J:137136
	enlarged tectum	J:137136
	normal nervous system phenotype	J:137136
Fgf8tm1Mrc/Fgf8+ Fgf9tm1Dor/Fgf9+ Fgfr3tm1.1Aomw/Fgfr3+ involves: 129 * BALB/c * C57BL/6	impaired hearing	J:143356
	increased or absent threshold for auditory brainstem response	J:143356
Fgf8tm1Mrc/Fgf8+ Fgfr3tm1.1Aomw/Fgfr3+ involves: 129 * BALB/c * C57BL/6	impaired hearing	J:143356
	increased or absent threshold for auditory brainstem response	J:143356
Fgf10tm1Ska/Fgf10+ Fgf8tm1Moon/Fgf8tm1Moon Mesp1tm2(cre)Ysa/Mesp1+ involves: C57BL/6NCrlj * CBA/JNCrlj	aberrant origin of the right subclavian artery	J:170879
	abnormal aortic arch morphology	J:170879
	abnormal cardiac outflow tract development	J:170879
	abnormal cardiovascular development	J:170879
	abnormal common carotid artery morphology	J:170879
	abnormal fourth pharyngeal arch artery morphology	J:170879
	abnormal pharyngeal arch artery morphology	J:170879
	abnormal sixth pharyngeal arch artery morphology	J:170879
	abnormal third pharyngeal arch artery morphology	J:170879
	decreased heart right ventricle size	J:170879
	double outlet right ventricle	J:170879
	right aortic arch	J:170879
	second pharyngeal arch hypoplasia	J:170879
	third pharyngeal arch hypoplasia	J:170879
	ventricular septal defect	J:170879
Fgf10tm1Ska/Fgf10tm1Ska Fgf8tm1Moon/Fgf8tm1Moon Mesp1tm2(cre)Ysa/Mesp1+ involves: C57BL/6NCrlj * CBA/JNCrlj	aberrant origin of the right subclavian artery	J:170879
	abnormal aortic arch morphology	J:170879
	abnormal cardiac epithelial to mesenchymal transition	J:170879
	abnormal cardiac neural crest cell migration	J:170879
	abnormal cardiac outflow tract development	J:170879
	abnormal cardiovascular development	J:170879
	abnormal common carotid artery morphology	J:170879
	abnormal fourth pharyngeal arch artery morphology	J:170879
	abnormal pharyngeal arch artery morphology	J:170879
	abnormal sixth pharyngeal arch artery morphology	J:170879
	abnormal third pharyngeal arch artery morphology	J:170879
	decreased heart right ventricle size	J:170879
	double outlet right ventricle	J:170879
	second pharyngeal arch hypoplasia	J:170879
	third pharyngeal arch hypoplasia	J:170879
	ventricular septal defect	J:170879
Fgf17tm1Dor/Fgf17tm1Dor Fgf8tm1.1Jyhl/Fgf8tm1.1Jyhl involves: 129S6/SvEvTac	abnormal cerebellum anterior vermis morphology	J:156717
	decreased inferior colliculus size	J:156717
Gbx2tm1.1Mrt/Gbx2+ Fgf8tm1.4Mrt/Fgf8+ B6.129-Gbx2tm1.1Mrt Fgf8tm1.4Mrt	abnormal pharyngeal arch artery morphology	J:100584
	retroesophageal right subclavian artery	J:100584
	right aortic arch	J:100584
Gbx2tm1.1Mrt/Gbx2tm1.1Mrt Fgf8tm1.4Mrt/Fgf8+ B6.129-Gbx2tm1.1Mrt Fgf8tm1.4Mrt	abnormal neural crest cell migration	J:100584
	abnormal pharyngeal arch artery morphology	J:100584
	abnormal thymus development	J:100584
	interrupted aortic arch, type b	J:100584
	retroesophageal right subclavian artery	J:100584
	right aortic arch	J:100584
	small ears	J:100584
	small mandible	J:100584