Foxg1^tm1M
Targeted Allele Detail

Summary

• Symbol: Foxg1^tm1M
• Name: forkhead box G1; targeted mutation 1, Memorial Sloan Kettering Cancer Center
• MGI ID: MGI:1857771
• Synonyms: BF-1-, BF1-, BF1(-^lacZ), Foxg1^-, Foxg1^lacZ
• Gene: Foxg1 Location: Chr12:49429666-49433650 bp, + strand Genetic Position: Chr12, 21.78 cM
• Alliance: Foxg1^tm1M page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:26720
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of the coding region was replaced with a lacZ and neomycin cassette. The lacZ sequence was fused in-frame following the first 13 codons of the gene. (J:26720)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	223 assay results
In Structures Affected by this Mutation:	18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxg1 Mutation: 28 strains or lines available

References

• Original: J:26720 Xuan S, et al., Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres. Neuron. 1995 Jun;14(6):1141-52
• All: 26 reference(s)