Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1M mutation
(0 available);
any
Foxg1 mutation
(28 available)
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nervous system
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• accelerated neuronal differentiation in the neocortical neuroepithelium resulting in a marked increase in the thickness of the mantle
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• neocortical progenitors in the dorsal telencephalon show a rapid increase in cell cycle length between E11.5 and E17.5 instead of the gradual increase in the length seen in wild-type mice
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• thickness of the mantle zone in the dorsal telencephalon is increased due to accelerated neuronal differentiation
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• dorsal telencephalon is small
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• neocortex has an irregular contour
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embryo
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• thickness of the mantle zone in the dorsal telencephalon is increased due to accelerated neuronal differentiation
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cellular
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• accelerated neuronal differentiation in the neocortical neuroepithelium resulting in a marked increase in the thickness of the mantle
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• neocortical progenitors in the dorsal telencephalon show a rapid increase in cell cycle length between E11.5 and E17.5 instead of the gradual increase in the length seen in wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1M mutation
(0 available);
any
Foxg1 mutation
(28 available)
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mortality/aging
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• all homozygotes are born alive but die within 20 minutes after birth
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respiratory system
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• mutant nasal placodes fail to grow normally after E9.5
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• mutant nasal epithelium fails to grow normally after E9.5
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• all newborn homozygotes make intermittent gasping motions
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• at autopsy, respiratory alveoli appear uninflated, indicating respiratory failure
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nervous system
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• at E12.5, the dorsal telencephalon is reduced in size whereas the ventral telencephalon is nearly absent
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• development of the ventral telencephalon is more severely affected than that of the dorsal telencephalon
• proliferation of ventral telencephalic neuroepithelium is reduced progressivley such that growth stops at E10.5
• abnormal proliferation of dorsal telencephalic neuroepithelium becomes more severe as development proceeds
• at E12.5, dorsal telencephalic vesicles are positioned more ventrally and closer to the level of the eyes
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• by E10.5, mutant brains exhibit significantly smaller telencephalic vesicles; this size difference is pronounced at E12.5
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• newborn homozygotes exhibit a 95% mass reduction of the cerebral hemispheres which rest on the dorsolateral surface of the diencephalon
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• at E12.5, mutant brains display an uneven cerebral cortex due to buckling of the neuroepithelium and to variations in cortical tissue thickness
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• mutant olfactory bulbs are significantly smaller than wild-type
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• at E12.5, mutant ganglionic eminences are replaced by a thin neuroepithelium
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craniofacial
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• newborn homozygotes display flattening of the frontal skull
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• mutant nasal placodes fail to grow normally after E9.5
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• mutant nasal epithelium fails to grow normally after E9.5
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vision/eye
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• newborn homozygotes display ellipsoid instead of round eyes
• ventral rotation of the entire eye is observed at E12.5
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• newborn homozygotes display an irregular retinal contour, that is pronounced in the nasal retina
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• at E12.5, mutant eyes display a wavy anterior retinal neuroepithelium
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homeostasis/metabolism
behavior/neurological
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• newborn homozygotes are flaccid and exhibit minimal spontaneous movement
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skeleton
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• newborn homozygotes display flattening of the frontal skull
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taste/olfaction
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• mutant nasal placodes fail to grow normally after E9.5
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• mutant nasal epithelium fails to grow normally after E9.5
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growth/size/body
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• mutant nasal epithelium fails to grow normally after E9.5
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Allelic
Composition |
Foxg1tm1M/Foxg1+
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Genetic
Background |
involves: C57BL/6 * CBA |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1M mutation
(0 available);
any
Foxg1 mutation
(28 available)
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nervous system
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• reduction in dimensions of cerebral hemispheres is observed by postnatal day 4
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm1.1Mrt mutation
(1 available);
any
Fgf8 mutation
(18 available)
Fgf8tm1.4Mrt mutation
(0 available);
any
Fgf8 mutation
(18 available)
Foxg1tm1M mutation
(0 available);
any
Foxg1 mutation
(28 available)
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nervous system
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• at E10.5 in the telencephalic midline, extent of apoptosis in Foxg1 hypomorphs resembles wild-type more than Fgf8tm1.1Mrt/Fgf8tm1.4Mrt hypomorphs
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cellular
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• at E10.5 in the telencephalic midline, extent of apoptosis in Foxg1 hypomorphs resembles wild-type more than Fgf8tm1.1Mrt/Fgf8tm1.4Mrt hypomorphs
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1M mutation
(0 available);
any
Foxg1 mutation
(28 available)
Foxg1tm1(tTA)Lai mutation
(0 available);
any
Foxg1 mutation
(28 available)
Tg(tetO-Foxg1)1Lai mutation
(0 available)
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nervous system
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• size of the neocortex and proliferation of progenitor cells throughout the dorsal telencephalon are restored to normal levels by expression of the mutant protein
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• accelerated neuronal differentiation in the neocortical neuroepithelium resulting in a marked increase in the thickness of the mantle
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• thickness of the mantle zone in the dorsal telencephalon is increased due to accelerated neuronal differentiation
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• dorsomedial telencephalon is abnormal
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embryo
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• thickness of the mantle zone in the dorsal telencephalon is increased due to accelerated neuronal differentiation
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cellular
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• accelerated neuronal differentiation in the neocortical neuroepithelium resulting in a marked increase in the thickness of the mantle
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Analysis Tools