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Foxg1 Gene Detail
Summary
  • Symbol
    Foxg1
  • Name
    forkhead box G1
  • Synonyms
    2900064B05Rik, Bf1, BF-1, Hfh9, Hfhbf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347464
    NCBI Gene: 15228
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:49429666-49433650 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 21.78 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    86 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347464
 protein coding gene Chr12:49429443-49433650 (+)
129S1/SvImJ ENSMUSG00200028636
 protein coding gene Chr12:41363342-41439198 (+)
A/J ENSMUSG00195017390
 protein coding gene Chr12:43944709-44020651 (+)
AKR/J ENSMUSG00220025905
 protein coding gene Chr12:41967865-41972442 (+)
BALB/cJ ENSMUSG00180005936
 protein coding gene Chr12:42936666-43012520 (+)
C3H/HeJ ENSMUSG00175011077
 protein coding gene Chr12:45996956-46072816 (+)
C57BL/6NJ ENSMUSG00215010325
 protein coding gene Chr12:42371411-42447264 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017729
 protein coding gene Chr12:44995331-44999484 (+)
CAST/EiJ ENSTCUG00005008469
 protein coding gene Chr12:42545111-42620794 (+)
CBA/J ENSMUSG00210009174
 protein coding gene Chr12:42471473-42547336 (+)
DBA/2J ENSMUSG00185014024
 protein coding gene Chr12:44462431-44538288 (+)
FVB/NJ ENSMUSG00205012740
 protein coding gene Chr12:42280322-42356179 (+)
JF1/MsJ ENSUMUG00000002460
 protein coding gene Chr12:48584060-48588276 (+)
LP/J ENSMUSG00230014363
 protein coding gene Chr12:51487140-51562997 (+)
NOD/ShiLtJ ENSMUSG00190015206
 protein coding gene Chr12:41481326-41557184 (+)
NZO/HlLtJ ENSMUSG00225040477
 protein coding gene Chr12:53631670-53707526 (+)
PWK/PhJ ENSLUMG00010016035
 protein coding gene Chr12:42689104-42770082 (+)
SPRET/EiJ ENSMSPG00010015346
 protein coding gene Chr12:43937194-43941155 (+)
WSB/EiJ ENSIUOG00005003419
 protein coding gene Chr12:42307107-42405575 (+)



Homology
more
  • Human Ortholog
    FOXG1, forkhead box G1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXG1, forkhead box G1
  • Synonyms
    BF1, BF2, FHKL3, FKH2, FKHL1, FKHL2, FKHL3, FKHL4, FOXG1A, FOXG1B, FOXG1C, HBF-1, HBF-2, HBF2, HBF-3, HBF-G2, HFK1, HFK2, HFK3, KHL2, QIN
  • Links
    NCBI Gene ID: 2290
    UniProt: P55316

  • Chr Location
    14q12; chr14:28764329-28770277 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Foxg1 mouse models; 1 with human FOXG1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    65 phenotypes from 5 alleles in 9 genetic backgrounds
    222 phenotypes from multigenic genotypes
    2 images
    390 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit dramatically reduced cerebral hemispheres, missing ventral telencephalic structures, impaired migration of efferent thalamocortical axons, and multiple eye defects. Mutants die at birth from respiratory failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1306
  • Tissues
    273
  • cDNA Data
    31
  • Literature Summary
    263
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15228 NCBI Gene Model | MGI Sequence Detail 3985 C57BL/6J ±  kb
    transcript NM_001160112 RefSeq | MGI Sequence Detail 3986 ZRU/MplStud  
    polypeptide Q60987 UniProt | EBI | MGI Sequence Detail 481 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      Genomic 4
      cDNA 45
      Primer pair 11
      Other 28
      Antibodies 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16692, MGI:1920272, MGI:99896
    References
    more
    • Summaries
      All 645
      Developmental Gene Expression 263
      Diseases 7
      Gene Ontology 24
      Phenotypes 390
    • Earliest
      J:20861 Tao W, et al., Telencephalon-restricted expression of BF-1, a new member of the HNF-3/fork head gene family, in the developing rat brain. Neuron. 1992 May;8(5):957-66
    • Latest
      J:388885 Lin CY, et al., A 3D amphioxus brain atlas illuminates the blueprint of the ancestral chordate brain and highlights unique vertebrate innovations. Sci Adv. 2026 Jul 3;12(27):eaee5076
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory