Phenotypes for Foxg1 MGI:8220251 MGI Mouse

• center time in the open field is decreased as mice age from P30 to P90, indicating increased anxiety

increased grooming behavior ( J:367353 )

• mice show increased repetitive grooming at P30, P60, and P90

• mice show reduced hanging time in the wire hang test, which worsens as mice age

behavioral arrest ( J:367353 )

• mice exhibit extended behavior arrest (paused locomotion for longer than 3 min at one episode) during free exploration of the arena of the open field; 11% of mice at P30, 22% at P60, and 47% at P90 exhibit this extended behavior arrest

• during the episodes of pronounced stops, mice show a high degree of postural control, positioning their bodies facing the center of the arena, and no apparent overt movements, such as visual survey, rearing or digging

decreased locomotor activity ( J:367353 )

• in the open field test, mice move less at P60 and P90 and show a tendency for travel distance reduction over time at P30

• mice that do not present prolonged behavior arrests show decreased travel distance

stereotypic behavior ( J:367353 )

• mice bury more marbles at P30 but fewer marbles at P60 and P90, indicating age-dependent changes in marble-burying behavior

increased oligodendrocyte progenitor number ( J:367353 )

• OLIG2+ oligodendrocyte lineage cells, most of which represent oligodendrocyte precursor cells, are increased in the cortex

abnormal neuron differentiation ( J:367353 )

• during cortical neurogenesis, the production of deep-layer neurons is increased and the reduction of upper-layer neurons persists in the mature cortex

increased radial glial cell number ( J:367353 )

• PAX6+ radial glial cells are increased in the cortex at E16

abnormal oligodendrocyte differentiation ( J:367353 )

• oligodendrocyte development process is disrupted

abnormal cortical ventricular zone morphology ( J:367353 )

• the number of phosphor-histone H3+ proliferating cells in the ventricular zone, especially at the ventricular surface, is increased in the cortex

abnormal brain interneuron morphology ( J:367353 )

• DLX1+ GABAergic interneurons are decreased in the cortex

decreased brain size ( J:367353 )

• adults exhibit smaller brains

decreased brain weight ( J:367353 )

• adults exhibit reduced brain weight despite no difference in body weight

decreased corpus callosum size ( J:367353 )

• adults show longitudinally shortened corpus callosum

absent corpus callosum ( J:367353 )

• a substantial fraction of callosal axons is stalled at the midline and forms the Probst bundle, leading to corpus callosum agenesis

abnormal dentate gyrus morphology ( J:367353 )

• malformation of the dentate gyrus

small hippocampus ( J:367353 )

• size of the hippocampus is reduced

thin cerebral cortex ( J:367353 )

• thinner cortex by E16

abnormal innervation ( J:367353 )

• mice show an increased number of aberrant L1+ axon bundles crossing the cortical plate toward the superficial area; these displaced L1+ axons express netrin G1 indicating they are derived from the thalamocortical neurons

abnormal myelination ( J:367353 )

• myelination is defective in the cortex, as shown by a decrease of MBP+ myelinated area and MBP immunostaining

• brains show a reduction of the arborization and complexity of myelination patterns indicating that microstructural organization of myelination is impaired