About   Help   FAQ
Targeted Allele Detail
Symbol: Tbx1tm1Bld
Name: T-box 1; targeted mutation 1, Antonio Baldini
MGI ID: MGI:2179136
Synonyms: Tbx1-, Tbx1lacZ
Gene: Tbx1  Location: Chr16:18399729-18409412 bp, - strand  Genetic Position: Chr16, Syntenic
Alliance: Tbx1tm1Bld page
Cleft palate, absent thymus and ear and cardiovascular abnormalities in Tbx1tm1Bld/Tbx1tm1Bld mice

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:67409
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsAn IRES-lacZ reporter gene followed by a loxP-flanked neomycin resistance cassette was inserted into exon 5, which encodes part of the T box domain resulting in a functionally null allele. (J:67409)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 296 assay results
4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 46 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tbx1 Mutation:  34 strains or lines available
Original:  J:67409 Lindsay EA, et al., Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice. Nature. 2001 Mar 1;410(6824):97-101
All:  65 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.13
The Jackson Laboratory