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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Sox2
SRY (sex determining region Y)-box 2
MGI:98364
127 phenotypes from 20 alleles in 23 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh/Gt(ROSA)26Sor+
Tg(Sftpc-cre)1Blh/0
involves: 129S/SvEv * C57BL/6 * DBA/2
abnormal lung morphology J:161806
bronchial epithelial hyperplasia J:161806
bronchiolar epithelial hyperplasia J:161806
increased lung adenocarcinoma incidence J:161806
lung epithelium hyperplasia J:161806
premature death J:161806
respiratory distress J:161806
Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh/Gt(ROSA)26Sor+
Scgb1a1tm1(cre/ERT)Blh/Scgb1a1+
involves: 129S6/SvEv * C57BL/6
bronchial epithelial hyperplasia J:161806
normal neoplasm J:161806
Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh/Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh
Scgb1a1tm1(cre/ERT)Blh/Scgb1a1+
involves: 129S6/SvEv * C57BL/6
bronchial epithelial hyperplasia J:161806
increased lung adenocarcinoma incidence J:161806
Sox2lcc/Sox2+
involves: 101/H * C3H/HeH
abnormal awl hair morphology J:77358
abnormal zigzag hair morphology J:77358
diluted coat color J:77358
head bobbing J:77358
Sox2lcc/Sox2lcc
involves: 101/H * C3H/HeH
abnormal awl hair morphology J:77358
abnormal guard hair morphology J:77358
abnormal inner ear morphology J:98458
abnormal semicircular canal morphology J:98458
abnormal sensory capabilities/reflexes/nociception J:77358
abnormal sulcus ampullaris morphology J:98458
abnormal zigzag hair morphology J:77358
absent cochlear hair cells J:98458
absent cochlear nerve compound action potential J:77358
circling J:77358
decreased cochlear coiling J:98458
head bobbing J:77358
small utricle J:98458
small vestibular saccule J:98458
yellow coat color J:77358
Sox2lcc/Sox2tm1Rlb
involves: 101/H * 129S/SvEv * C3H/HeH
abnormal semicircular canal morphology J:98458
abnormal sulcus ampullaris morphology J:98458
postnatal lethality J:98458
small utricle J:98458
small vestibular saccule J:98458
Sox2lcc/Sox2ysb
involves: 101/H * C3H/HeH * C57BL/6 * CBA
abnormal sensory capabilities/reflexes/nociception J:77358
absent cochlear nerve compound action potential J:77358
circling J:77358
head bobbing J:77358
yellow coat color J:77358
Sox2tm1.1Knd/Sox2tm1.1Knd
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
normal embryo phenotype J:217059
Sox2tm1.1Lan/Sox2tm1.1Lan
Tg(Cryaa-cre)10Mlr/0
involves: C57BL/6 * FVB/N * SJL
normal vision/eye phenotype J:152850
Sox2tm1.1Lan/Sox2tm1.1Lan
Tg(Scgb1a1-cre)1Kkw/0
involves: 129/Sv * C57BL/6
abnormal bronchiole epithelium morphology J:155963
abnormal lung epithelium morphology J:155963
abnormal respiratory mucosa goblet cell morphology J:155963
absent club cells J:155963
absent respiratory motile cilia J:155963
absent respiratory mucosa goblet cells J:155963
Sox2tm1.1Vep/Sox2+
Not Specified
no abnormal phenotype detected J:99610
Sox2tm1.1Vep/Sox2tm1.2Vlcg
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac
absent egg cylinders J:191980
absent embryonic epiblast J:191980
embryonic lethality between implantation and placentation, complete penetrance J:191980
increased trophoblast giant cell number J:191980
Sox2tm1.1Vlcg/Sox2tm1.1Vlcg
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac
normal behavior/neurological phenotype J:191980
normal growth/size/body region phenotype J:191980
Sox2tm1.1Vlcg/Sox2tm1.1Vlcg
involves: 129S6/SvEvTac * C57BL/6NTac
no abnormal phenotype detected J:200671
Sox2tm1.2Vlcg/Sox2+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac
no abnormal phenotype detected J:191980
Sox2tm1.2Vlcg/Sox2tm1.2Vlcg
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac
absent egg cylinders J:191980
absent embryonic epiblast J:191980
embryonic lethality between implantation and placentation, complete penetrance J:191980
increased trophoblast giant cell number J:191980
Sox2tm1Lpev/Sox2+
Not Specified
no abnormal phenotype detected J:108452
Sox2tm1Lpev/Sox2tm2Lpev
involves: 129S/SvEv * C57BL/6
abnormal digestive system physiology J:122531
abnormal esophageal squamous epithelium morphology J:122531
abnormal esophagus morphology J:122531
abnormal stomach morphology J:122531
esophageal atresia J:122531
neonatal lethality, complete penetrance J:122531
respiratory distress J:122531
tracheoesophageal fistula J:122531
Sox2tm1Lpev/Sox2tm2Lpev
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129S/SvEv
abnormal eye size J:108452
Sox2tm1Lpev/Sox2tm3Lpev
involves: 129S/SvEv
abnormal esophagus morphology J:112945
abnormal fungiform papillae morphology J:112945
abnormal palate morphology J:112945
abnormal stomach morphology J:112945
abnormal tongue morphology J:112945
anophthalmia J:108452
normal digestive/alimentary phenotype J:112945
disorganized retinal layers J:108452
microphthalmia J:108452
neonatal lethality, complete penetrance J:112945
retina hyperplasia J:108452
Sox2tm1Lpev/Sox2tm4Lpev
involves: 129S/SvEv
anophthalmia J:108452
disorganized retinal layers J:108452
microphthalmia J:108452
optic nerve hypoplasia J:108452
retina hyperplasia J:108452
Sox2tm1Okud/Sox2tm1Okud
Tg(Nes-cre)1Sasa/?
involves: 129P2/OlaHsd * C57BL/6
abnormal neuronal precursor proliferation J:138323
enlarged lateral ventricles J:138323
neonatal lethality, complete penetrance J:138323
Sox2tm1Rlb/Sox2+
involves: 129S/SvEv
reduced male fertility J:81180
Sox2tm1Rlb/Sox2+
involves: 129S/SvEv * MF1
abnormal adenohypophysis development J:114458
abnormal pituitary gland morphology J:114458
abnormal seminiferous tubule morphology J:114458
bifurcated Rathke's pouch J:114458
decreased adrenocorticotropin level J:114458
decreased body size J:114458
decreased growth hormone level J:114458
decreased luteinizing hormone level J:114458
decreased prolactin level J:114458
decreased somatotroph cell number J:114458
decreased thyroid-stimulating hormone level J:114458
normal digestive/alimentary phenotype J:114458
oligozoospermia J:114458
postnatal lethality, incomplete penetrance J:114458
reduced male fertility J:81180, J:114458
small adenohypophysis J:114458
small testis J:114458
normal vision/eye phenotype J:114458
Sox2tm1Rlb/Sox2tm1Rlb
either: (involves: 129S/SvEv) or (involves: 129S/SvEv * MF1)
abnormal ectoderm development J:81180
absent ectoplacental cone J:81180
absent egg cylinders J:81180
embryonic lethality between implantation and somite formation, complete penetrance J:81180
Sox2tm1Rlb/Sox2ysb
involves: 129S/SvEv * C57BL/6 * CBA
abnormal semicircular canal morphology J:98458
abnormal sulcus ampullaris morphology J:98458
abnormal vestibular saccule morphology J:98458
circling J:98458
deafness J:98458
yellow coat color J:98458
Sox2tm1Vep/Sox2+
Not Specified
no abnormal phenotype detected J:99610
Sox2tm2Lpev/Sox2+
involves: 129S/SvEv
no abnormal phenotype detected J:108452
Sox2tm2Lpev/Sox2tm2.1Lpev
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129S/SvEv
abnormal retina morphology J:108452
retina hypoplasia J:108452
Sox2tm2Lpev/Sox2tm2Lpev
involves: 129S/SvEv
no abnormal phenotype detected J:108452
Sox2tm2Lpev/Sox2tm2Lpev
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129S/SvEv
abnormal eye size J:108452
abnormal retinal progenitor cell morphology J:108452
Sox2tm2Lpev/Sox2tm3Lpev
involves: 129S/SvEv * C57BL/6
abnormal Ebner's gland morphology J:122531
abnormal epiglottis morphology J:122531
abnormal esophageal squamous epithelium morphology J:122531
abnormal esophagus morphology J:122531
abnormal salivary gland morphology J:122531
abnormal stomach morphology J:122531
absent anterior lingual gland J:122531
absent palatine gland J:122531
normal digestive/alimentary phenotype J:122531
neonatal lethality, complete penetrance J:122531
respiratory distress J:122531
normal respiratory system phenotype J:122531
Sox2tm2Skn/Sox2tm3Skn
involves: 129S/SvEv * 129S1/Sv * C57BL/6J
abnormal brain morphology J:92063
abnormal cerebral cortex morphology J:92063
abnormal ependyma morphology J:92063
abnormal nervous system morphology J:92063
abnormal nervous system physiology J:92063
abnormal neuron differentiation J:92063
abnormal thalamus morphology J:92063
bidirectional circling J:92063
decreased body size J:92063
decreased corpus callosum size J:92063
dystonia J:92063
enlarged lateral ventricles J:92063
enlarged third ventricle J:92063
motor neuron degeneration J:92063
nonconvulsive seizures J:92063
premature death J:92063
prenatal lethality, incomplete penetrance J:92063
Sox2tm2Skn/Sox2tm4.1Skn
Tg(Nes-cre)1Kln/0
either: (involves: 129S/Sv * C57BL/6 * SJL) or (involves: 129S/Sv * C57BL/6 * DBA/2 * SJL)
abnormal cerebral cortex morphology J:154650
abnormal corpus callosum morphology J:154650
abnormal dentate gyrus morphology J:154650
abnormal hippocampus development J:154650
abnormal neuron differentiation J:154650
absent dentate gyrus J:154650
enlarged lateral ventricles J:154650
loss of hippocampal neurons J:154650
premature death J:154650
small hippocampus J:154650
Sox2tm3(TK)Hoch/Sox2+
involves: 129S4/SvJae * C57BL/6
abnormal stomach morphology J:177655
decreased body size J:177655
decreased male germ cell number J:177655
edema J:177655
gastrointestinal ulcer J:177655
premature death J:177655
small testis J:177655
stomach inflammation J:177655
tongue inflammation J:177655
Sox2tm3Lpev/Sox2+
involves: 129S/SvEv
no abnormal phenotype detected J:108452
Sox2tm3Lpev/Sox2tm3Lpev
involves: 129S/SvEv
no abnormal phenotype detected J:108452
Sox2tm4.1Skn/Sox2tm4.1Skn
Tbx18tm2.1(cre)Sev/Tbx18+
involves: 129S1/Sv
abnormal hair growth J:191082
normal integument phenotype J:191082
Sox2tm4.1Skn/Sox2tm4.1Skn
Tg(Sox2-cre/ERT2)1Skn/0
involves: 129S1/Sv * 129S4/SvJae
abnormal neuron differentiation J:154650
abnormal neuronal precursor proliferation J:154650
abnormal radial glial cell morphology J:154650
Sox2tm4Lpev/Sox2+
involves: 129S/SvEv
no abnormal phenotype detected J:108452
Sox2tm4Lpev/Sox2tm4Lpev
involves: 129S/SvEv
no abnormal phenotype detected J:108452
Sox2ysb/Sox2+
involves: C57BL/6 * CBA
yellow coat color J:77358
Sox2ysb/Sox2ysb
involves: C57BL/6 * CBA
abnormal auchene hair morphology J:77358
abnormal awl hair morphology J:77358
abnormal cochlear hair cell morphology J:98458
abnormal inner ear morphology J:98458
abnormal pinna reflex J:77358
abnormal placing response J:77358
abnormal semicircular canal morphology J:98458
abnormal sulcus ampullaris morphology J:98458
abnormal zigzag hair morphology J:77358
absent vestibular hair cells J:98458
circling J:77358
deafness J:77358
decreased cochlear coiling J:98458
decreased cochlear nerve compound action potential J:77358
dilated cochlea J:98458
head tossing J:77358
impaired righting response J:77358
impaired swimming J:77358
yellow coat color J:77358

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory