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Sox2tm1.1Knd
Targeted Allele Detail
Summary
Symbol: Sox2tm1.1Knd
Name: SRY (sex determining region Y)-box 2; targeted mutation 1.1, Hisato Kondoh
MGI ID: MGI:5613017
Synonyms: deltaN1, Sox2deltaN1
Gene: Sox2  Location: Chr3:34704554-34706610 bp, + strand  Genetic Position: Chr3, 16.93 cM, cytoband A2-B
Alliance: Sox2tm1.1Knd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:217059
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsIRES sequence followed by the EGFP gene and an FRT site flanked neomycin resistance gene cassette were inserted downstream of the open reading frame. Flp-mediated recombination removed the neo cassette. (J:217059)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 10 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox2 Mutation:  56 strains or lines available
References
Original:  J:217059 Takemoto T, et al., Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells. Nature. 2011 Feb 17;470(7334):394-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory