Sox2^tm1.1Knd
Targeted Allele Detail

Summary

• Symbol: Sox2^tm1.1Knd
• Name: SRY (sex determining region Y)-box 2; targeted mutation 1.1, Hisato Kondoh
• MGI ID: MGI:5613017
• Synonyms: deltaN1, Sox2^deltaN1
• Gene: Sox2 Location: Chr3:34704554-34706610 bp, + strand Genetic Position: Chr3, 16.93 cM, cytoband A2-B
• Alliance: Sox2^tm1.1Knd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217059
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: IRES sequence followed by the EGFP gene and an FRT site flanked neomycin resistance gene cassette were inserted downstream of the open reading frame. Flp-mediated recombination removed the neo cassette. (J:217059)

Expression

In Mice Carrying this Mutation:

10 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox2 Mutation: 56 strains or lines available

References

• Original: J:217059 Takemoto T, et al., Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells. Nature. 2011 Feb 17;470(7334):394-8
• All: 3 reference(s)