102 phenotypes from 9 alleles in 13 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Meox2tm1(cre)Sor/Meox2+ Raf1tm2Bacc/Raf1tm2.1Bacc involves: 129P2/OlaHsd * 129S4/SvJaeSor	prenatal lethality, complete penetrance	J:105998
Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd Raf1tm2Bacc/Raf1tm2Bacc involves: 129P2/OlaHsd	no abnormal phenotype detected	J:172200
Raf1tm1.1Bgn/Raf1+ involves: 129S6/SvEvTac * C57BL/6NCr	abnormal cardiovascular system physiology	J:172034
	abnormal common myeloid progenitor cell morphology	J:172034
	abnormal facial morphology	J:172034
	abnormal heart left ventricle morphology	J:189143
	abnormal heart left ventricle pressure	J:172034
	cardiac fibrosis	J:172034
	cardiac hypertrophy	J:172034
	cardiac interstitial fibrosis	J:172034
	normal cardiovascular system phenotype	J:172034
	decreased body length	J:172034
	decreased body size	J:172034
	decreased body weight	J:172034
	decreased cardiac muscle contractility	J:172034
	decreased cranium height	J:172034
	dilated cardiomyopathy	J:172034
	enlarged spleen	J:172034
	flattened snout	J:172034
	increased cardiac muscle contractility	J:172034, J:189143
	increased cardiac output	J:172034, J:189143
	increased cardiac stroke volume	J:172034, J:189143
	increased cranium width	J:172034
	increased heart left ventricle size	J:172034
	increased heart right atrium size	J:172034
	increased heart ventricle size	J:172034
	increased heart weight	J:172034
	increased left ventricle systolic pressure	J:172034
	increased leukocyte cell number	J:172034
	increased monocyte cell number	J:172034
	increased myocardial fiber size	J:172034
	increased neutrophil cell number	J:172034
	increased response of heart to induced stress	J:172034
	increased susceptibility to induced morbidity/mortality	J:172034
	ocular hypertelorism	J:172034
	thick interventricular septum	J:172034
	thick ventricular wall	J:172034
Raf1tm1b(EUCOMM)Wtsi/Raf1+ C57BL/6N-Raf1tm1b(EUCOMM)Wtsi/Ics	abnormal lens morphology	J:211773
	cataract	J:211773
Raf1tm1b(EUCOMM)Wtsi/Raf1tm1b(EUCOMM)Wtsi C57BL/6N-Raf1tm1b(EUCOMM)Wtsi/Ics	preweaning lethality, complete penetrance	J:211773
Raf1tm1Bacc/Raf1tm1Bacc involves: 129P2/OlaHsd * 129/Sv	abnormal hepatocyte morphology	J:69056
	abnormal liver sinusoid morphology	J:69056
	abnormal placenta labyrinth morphology	J:69056
	abnormal placental labyrinth vasculature morphology	J:69056
	decreased embryo size	J:69056
	decreased embryo weight	J:69056
	decreased placenta weight	J:69056
	decreased sensitivity to induced cell death	J:69056
	decreased spongiotrophoblast size	J:69056
	embryonic growth retardation	J:69056
	embryonic lethality during organogenesis, complete penetrance	J:69056
	increased fibroblast apoptosis	J:69056
	increased hepatoblast apoptosis	J:69056
	increased sensitivity to induced cell death	J:69056
	liver hypoplasia	J:69056
	pale liver	J:69056
	pallor	J:69056
	small liver	J:69056
	small placenta	J:69056
Raf1tm1Bacc/Raf1tm1Bacc involves: 129P2/OlaHsd * C57BL/6	abnormal hepatocyte morphology	J:69056
	abnormal liver sinusoid morphology	J:69056
	abnormal placenta labyrinth morphology	J:69056
	abnormal placental labyrinth vasculature morphology	J:69056
	decreased embryo size	J:69056
	decreased embryo weight	J:69056
	decreased placenta weight	J:69056
	decreased sensitivity to induced cell death	J:69056
	decreased spongiotrophoblast size	J:69056
	embryonic growth retardation	J:69056
	increased apoptosis	J:69056
	increased fibroblast apoptosis	J:69056
	increased hepatoblast apoptosis	J:69056
	increased sensitivity to induced cell death	J:69056
	lethality throughout fetal growth and development, complete penetrance	J:69056
	liver hypoplasia	J:69056
	pale liver	J:69056
	pallor	J:69056
	small liver	J:69056
	small placenta	J:69056
Raf1tm1Ulb/Raf1tm1Ulb involves: 129P2/OlaHsd * C57BL/6	abnormal apoptosis	J:89619
	abnormal somite development	J:89619
	abnormal vasculogenesis	J:89619
	absent vitelline blood vessels	J:89619
	anemia	J:89619
	decreased body weight	J:89619
	decreased embryo size	J:89619
	embryonic growth arrest	J:89619
	hemorrhage	J:89619
	liver hypoplasia	J:89619
	prenatal lethality	J:89619
Raf1tm1Ulb/Raf1tm1Ulb involves: 129P2/OlaHsd * MF1	abnormal placenta development	J:89619
	abnormal somite development	J:89619
	decreased body weight	J:89619
	decreased embryo size	J:89619
	embryonic growth arrest	J:89619
	prenatal lethality	J:89619
Raf1tm1Zim/Raf1tm1Zim involves: 129/Sv * 129T2/SvEms	abnormal neural tube morphology	J:50696
	decreased embryo size	J:50696
	distended pericardium	J:50696
	embryonic growth arrest	J:50696
	embryonic lethality during organogenesis, incomplete penetrance	J:50696
Raf1tm1Zim/Raf1tm1Zim involves: 129/Sv * C57BL/6	abnormal neural tube morphology	J:50696
	decreased embryo size	J:50696
	distended pericardium	J:50696
	embryonic growth arrest	J:50696
	embryonic lethality during organogenesis, incomplete penetrance	J:50696
Raf1tm1Zim/Raf1tm1Zim involves: 129/Sv * CD-1	abnormal dermal layer morphology	J:50696
	abnormal epidermal layer morphology	J:50696
	abnormal epidermis stratum corneum morphology	J:50696
	abnormal placenta labyrinth morphology	J:50696
	abnormal placenta morphology	J:50696
	abnormal placental labyrinth vasculature morphology	J:50696
	abnormal pulmonary alveolus morphology	J:50696
	abnormal spongiotrophoblast layer morphology	J:50696
	decreased embryo size	J:50696
	decreased fetal weight	J:50696
	decreased fibroblast proliferation	J:50696
	embryonic growth retardation	J:50696
	embryonic lethality during organogenesis, incomplete penetrance	J:50696
	eyelids open at birth	J:50696
	neonatal lethality, incomplete penetrance	J:50696
	respiratory failure	J:50696
	retina fold	J:50696
	small hair follicles	J:50696
	small lung	J:50696
	thin dermal layer	J:50696
	thin epidermis	J:50696
	underdeveloped hair follicles	J:50696
Raf1tm2.1Ara/Raf1+ involves: 129S6/SvEvTac * C57BL/6NCr	decreased body length	J:189143
Raf1tm2.1Ara/Raf1tm2.1Ara involves: 129S6/SvEvTac * C57BL/6NCr	abnormal cranium size	J:189143
	abnormal heart left ventricle morphology	J:189143
	cardiac hypertrophy	J:189143
	decreased body length	J:189143
	decreased body weight	J:189143
	decreased cranium width	J:189143
	enlarged heart	J:189143
	normal hematopoietic system phenotype	J:189143
	hunched posture	J:189143
	increased cardiac muscle contractility	J:189143
	increased cardiac output	J:189143
	increased cardiac stroke volume	J:189143
	increased heart weight	J:189143
	increased myocardial fiber size	J:189143
	premature death	J:189143
	ruffled hair	J:189143
	tremors	J:189143
Raf1tm2Bacc/Raf1tm2Bacc Tg(Mx1-cre)1Cgn/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	increased apoptosis	J:93687
Raf1tm2Bacc/Raf1tm2Bacc Tg(Myh6-cre)2182Mds/0 involves: C57BL/6J	cardiac fibrosis	J:93418
	decreased cardiac muscle contractility	J:93418
	decreased ventricle muscle contractility	J:93418
	dilated heart left ventricle	J:93418
	enlarged heart	J:93418
	increased cardiomyocyte apoptosis	J:93418
	thin myocardium	J:93418
Raf1tm2Ulb/Raf1tm2Ulb involves: 129P2/OlaHsd * C57BL/6 * MF1	no abnormal phenotype detected	J:89619