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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cd74
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
MGI:96534
42 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd1d1tm1.1Boes/Cd1d1tm1.1Boes
Cd74tm1Doi/Cd74tm1Doi
involves: 129S2/SvPas * C57BL/6 		abnormal dendritic cell antigen presentation J:151699
Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm2(Cd74/MOG)Awai/Gt(ROSA)26Sor+
Il10tm1Roer/Il10tm1Roer
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell physiology J:140751
decreased susceptibility to experimental autoimmune encephalomyelitis J:140751
Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
Smim3tm1Anjm/Smim3+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 		abnormal bone marrow morphology J:155870
decreased erythrocyte cell number J:155870
decreased erythroid progenitor cell number J:155870
decreased granulocyte monocyte progenitor cell number J:155870
decreased hematopoietic stem cell number J:155870
decreased megakaryocyte-erythroid progenitor cell number J:155870
increased mean corpuscular volume J:155870
thrombocytopenia J:155870
Cd74tm1Doi/Cd74tm1Doi
H2-DMatm1Doi/H2-DMatm1Doi
involves: 129S2/SvPas * C57BL/6 		abnormal professional antigen presenting cell physiology J:42482
decreased body size J:42482
decreased CD4-positive, alpha-beta T cell number J:42482
increased CD8-positive, alpha-beta T cell number J:42482
premature death J:42482
Cd74tm1Doi/Cd74tm1Doi
Tap1tm1Arp/Tap1tm1Arp
involves: 129S2/SvPas * C57BL/6 		abnormal T cell number J:113083
Cd74tm1Liz/Cd74tm1Liz
H2-DMatm1Liz/H2-DMatm1Liz
involves: 129S/SvEv * BALB/c 		decreased CD4-positive, alpha-beta T cell number J:113714
Cd74tm1Liz/Cd74tm1Liz
H2-DMatm1Luc/H2-DMatm1Luc
Tg(CD74)AR194Ayr/?
involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J 		abnormal antigen presentation via MHC class II J:88717
decreased CD4-positive, alpha-beta T cell number J:88717
Cd74tm1Liz/Cd74tm1Liz
H2-DMatm1Luc/H2-DMatm1Luc
Tg(CD74*)1Ayr/0
involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J 		abnormal antigen presentation via MHC class II J:88717
decreased CD4-positive, alpha-beta T cell number J:88717
Cd74tm1Liz/Cd74tm1Liz
Sppl2atm1Basc/Sppl2atm1Basc
B6.129-Sppl2atm1Basc Cd74tm1Liz 		decreased B cell number J:194664
decreased Peyer's patch number J:194664
normal immune system phenotype J:194664
Cd74tm1Liz/Cd74tm1Liz
Sppl2atm1Dgen/Sppl2atm1Dgen
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 		decreased follicular B cell number J:194595
normal immune system phenotype J:194595
Cd74tm3Liz/Cd74tm3Liz
involves: 129S/SvEv * C57BL/6 		abnormal antigen presentation via MHC class II J:82880
abnormal level of surface class II molecules J:82880
decreased interleukin-2 secretion J:72243
defective assembly of class II molecules J:82880
normal immune system phenotype J:82880
increased susceptibility to experimental autoimmune encephalomyelitis J:72243
H2-DMatm1Luc/H2-DMatm1Luc
Cd74tm1Doi/Cd74tm1Doi
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 		abnormal level of surface class II molecules J:45185
increased susceptibility to parasitic infection J:45185
Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+
involves: 129P2/OlaHsd * C57BL/6 		normal hematopoietic system phenotype J:155870
Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
involves: 129P2/OlaHsd * C57BL/6 		abnormal blood cell morphology J:155870
abnormal bone marrow cell number J:155870
abnormal common myeloid progenitor cell morphology J:155870
abnormal erythropoiesis J:155870
abnormal mast cell morphology J:155870
abnormal megakaryocyte morphology J:155870
abnormal megakaryocyte progenitor cell morphology J:155870
decreased bone marrow cell number J:155870
decreased erythrocyte cell number J:155870
decreased erythroid progenitor cell number J:155870
decreased granulocyte monocyte progenitor cell number J:155870
decreased granulocyte number J:155870
decreased hematopoietic stem cell number J:155870
decreased hemoglobin content J:155870
decreased megakaryocyte-erythroid progenitor cell number J:155870
decreased monocyte cell number J:155870
increased mean corpuscular volume J:155870
increased red blood cell distribution width J:155870
macrocytic anemia J:155870
macrocytosis J:155870
thrombocytopenia J:155870
Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
Trp53tm1Brd/Trp53+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 		decreased erythrocyte cell number J:155870
decreased erythroid progenitor cell number J:155870
decreased granulocyte monocyte progenitor cell number J:155870
decreased hematopoietic stem cell number J:155870
decreased megakaryocyte-erythroid progenitor cell number J:155870
increased mean corpuscular volume J:155870
thrombocytopenia J:155870
Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
Trp53tm1Brd/Trp53tm1Brd
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 		normal hematopoietic system phenotype J:155870
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory