Cd74^tm1Liz
Targeted Allele Detail

Summary

• Symbol: Cd74^tm1Liz
• Name: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); targeted mutation 1, Elizabeth K Bikoff
• MGI ID: MGI:1927530
• Synonyms: Ii^-, Ii^tm1Liz, MHCII^-
• Gene: Cd74 Location: Chr18:60936921-60945724 bp, + strand Genetic Position: Chr18, 34.41 cM
• Alliance: Cd74^tm1Liz page

Sppl2a^tm1Basc/Sppl2a^tm1Basc Cd74^tm1Liz/Cd74^tm1Liz B cells show normal morphology compared to the increased vacuoles in Sppl2a^tm1Basc/Sppl2a^tm1Basc B cells

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65918
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A MC1neopA cassette replaced the first intron and 11 nucleotides of the second exon. (J:65918)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Cd74 Mutation: 33 strains or lines available

References

• Original: J:65918 Bikoff EK, et al., Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression. J Exp Med. 1993 Jun 1;177(6):1699-712
• All: 57 reference(s)