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Sppl2atm1Basc
Targeted Allele Detail
Summary
Symbol: Sppl2atm1Basc
Name: signal peptide peptidase like 2A; targeted mutation 1, Bernd Schroder
MGI ID: MGI:5491887
Gene: Sppl2a  Location: Chr2:126732311-126775155 bp, - strand  Genetic Position: Chr2, 61.76 cM, cytoband F3
Alliance: Sppl2atm1Basc page
Atrophic Peyer's patches in Sppl2atm1Basc/Sppl2atm1Basc mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:194664
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into exon 2. Western confirmed the lack of protein expression in splenocytes. (J:194664)
Generation of the Sppl2atm1Basc allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sppl2a Mutation:  35 strains or lines available
References
Original:  J:194664 Schneppenheim J, et al., The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain. J Exp Med. 2013 Jan 14;210(1):41-58
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
02/20/2024
MGI 6.23
The Jackson Laboratory