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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Igh-J
immunoglobulin heavy chain, joining region
MGI:96461
36 phenotypes from 11 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Igh-Jtm1(3H9-VDJ)Mwg/Igh-Jtm1(3H9-VDJ)Mwg
involves: 129P2/OlaHsd * BALB/c * C57BL/6 		abnormal B cell receptor editing J:126940
Igh-Jtm1(CB20)Riho/Igh-J+
involves: C57BL/10 * DBA/1 		abnormal B cell differentiation J:179456
decreased pre-B cell number J:179456
increased immature B cell number J:179456
increased marginal zone B cell number J:179456
increased mature B cell number J:179456
increased susceptibility to induced arthritis J:179456
Igh-Jtm1(CB20)Riho/Igh-Jtm1(CB20)Riho
involves: C57BL/10 * DBA/1 		abnormal B cell differentiation J:179456
decreased pre-B cell number J:179456
increased immature B cell number J:179456
increased marginal zone B cell number J:179456
increased mature B cell number J:179456
increased susceptibility to induced arthritis J:179456
Igh-Jtm1(VDJ-KL25)Zbz/Igh-J+
involves: C57BL/6 * C57BL/6J * BALB/cJ 		increased IgG level J:86411
increased IgM level J:86411
Igh-Jtm1(VDJ-VI10)Zbz/Igh-J+
involves: C57BL/6 * C57BL/6J * BALB/cJ 		abnormal immune serum protein physiology J:86411
Igh-Jtm1.1Lave/Igh-J+
Not Specified 		abnormal B cell differentiation J:155798
decreased B cell number J:155798
decreased immature B cell number J:155798
decreased mature B cell number J:155798
decreased spleen weight J:155798
decreased T cell number J:155798
decreased transitional stage B cell number J:155798
decreased transitional stage T1 B cell number J:155798
decreased transitional stage T2 B cell number J:155798
increased pre-B cell number J:155798
increased pro-B cell number J:155798
Igh-Jtm1.1Lave/Igh-Jtm1.1Lave
Not Specified 		abnormal B cell differentiation J:155798
abnormal immunoglobulin level J:179317
arrested B cell differentiation J:179317
decreased B cell number J:155798, J:179317
decreased IgM level J:155798
decreased immature B cell number J:155798
decreased mature B cell number J:155798
decreased spleen weight J:155798
decreased T cell number J:155798
decreased transitional stage B cell number J:155798
decreased transitional stage T1 B cell number J:155798
decreased transitional stage T2 B cell number J:155798
increased IgG level J:155798
increased pre-B cell number J:155798
increased pro-B cell number J:155798
Igh-Jtm1Cgn/Igh-J+
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell differentiation J:64285
Igh-Jtm1Cgn/Igh-Jtm1Cgn
involves: 129P2/OlaHsd * C57BL/6 		absent mature B cells J:64285
arrested B cell differentiation J:64285
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
involves: 129P2/OlaHsd 		absent mature B cells J:137738
arrested B cell differentiation J:137738
increased late pro-B cell number J:137738
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
involves: 129P2/OlaHsd * C57BL/6 		abnormal T cell number J:113083
absent B cells J:70038
decreased IgM level J:70038
Igh-Jtm2(3H9-VDJ*)Mwg/Igh-J+
B6.129P2-Igh-Jtm2(3H9-VDJ*)Mwg 		decreased B cell number J:142389
increased anti-double stranded DNA antibody level J:142389
increased marginal zone B cell number J:142389
spleen hypoplasia J:142389
Igh-Jtm2(3H9-VDJ*)Mwg/Igh-J+
involves: 129P2/OlaHsd * BALB/c 		abnormal B cell receptor editing J:131138
abnormal marginal zone B cell morphology J:131138
increased anti-double stranded DNA antibody level J:131138
Igh-Jtm2(3H9-VDJ*)Mwg/Igh-J+
involves: 129P2/OlaHsd * BALB/c * C57BL/6 		abnormal B cell receptor editing J:126940
increased anti-double stranded DNA antibody level J:126940
Igh-Jtm2.1(4E10)Lave/Igh-Jtm2.1(4E10)Lave
involves: C57BL/6 		arrested B cell differentiation J:205708
decreased B-1a cell number J:205708
decreased IgG1 level J:205708
decreased IgG2b level J:205708
decreased IgG3 level J:205708
decreased IgG level J:205708
decreased IgM level J:205708
Igh-Jtm3(3H9-VDJ*)Mwg/Igh-Jtm3(3H9-VDJ*)Mwg
involves: 129P2/OlaHsd * BALB/c * C57BL/6 		abnormal B cell receptor editing J:126940
increased anti-double stranded DNA antibody level J:126940
Igh-Jtm3.1(48d)Lave/Igh-Jtm3.1(48d)Lave
involves: C57BL/6 		decreased B-1a cell number J:205708
decreased IgG1 level J:205708
decreased IgG2b level J:205708
decreased IgM level J:205708
normal immune system phenotype J:205708
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory