Icam1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Icam1
intercellular adhesion molecule 1
MGI:96392

31 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Icam1^tm1Bay/Icam1^tm1Bay Sele^tm2Alb/Sele^tm2Alb Selp^tm1Bay/Selp^tm1Bay involves: 129S7/SvEvBrd * C57BL/6	decreased acute inflammation	J:112286
	impaired neutrophil chemotaxis	J:112286
	increased neutrophil cell number	J:112286
	normal integument phenotype	J:112286
	skin edema	J:112286
Icam1^tm1Bay/Icam1^tm1Bay Sell^tm1Tft/Sell^tm1Tft B6.129-Sell^tm1Tft Icam1^tm1Bay	abnormal cellular extravasation	J:48271
	abnormal inflammatory response	J:124291
	abnormal leukocyte tethering or rolling	J:48271
	abnormal macrophage physiology	J:124291
	abnormal mast cell physiology	J:124291
	decreased angiogenesis	J:124291
	decreased keratinocyte migration	J:124291
	delayed wound healing	J:124291
	impaired macrophage chemotaxis	J:124291
	impaired wound healing	J:124291
	increased body weight	J:48271
	increased eosinophil cell number	J:48271
	increased lymphocyte cell number	J:48271
	increased monocyte cell number	J:48271
	increased neutrophil cell number	J:48271
	increased tumor growth/size	J:108135
Icam1^tm1Bay/Icam1^tm1Bay Selp^tm1Bay/Selp^tm1Bay B6.129S7-Icam1^tm1Bay Selp^tm1Bay/J	edema	J:119906
	normal immune system phenotype	J:119906
	normal nervous system phenotype	J:119906
Icam1^tm1Bay/Icam1^tm1Bay Selp^tm1Bay/Selp^tm1Bay either: B6.129S7-Selp^tm1Bay Icam1^tm1Bay or (involves: 129S7/SvEvBrd * C57BL/6)	impaired leukocyte tethering or rolling	J:31374
Icam1^tm1Bay/Icam1^tm1Bay Selp^tm1Bay/Selp^tm1Bay involves: 129S7/SvEvBrd * C57BL/6J	abnormal leukocyte migration	J:24239
	increased neutrophil cell number	J:24239
Icam1^tm1Jcgr/Icam1^tm1Jcgr Ldlr^tm1Her/Ldlr^tm1Her involves: 129S4/SvJae * 129S7/SvEvBrd	increased neutrophil cell number	J:69597
Icam1^tm1Jcgr/Icam1^tm1Jcgr Ldlr^tm1Her/Ldlr^tm1Her Vcam1^tm1Dmil/Vcam1^tm1Dmil involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	decreased circulating cholesterol level	J:69597
	decreased susceptibility to atherosclerosis	J:69597
	increased leukocyte cell number	J:69597
	increased lymphocyte cell number	J:69597
	increased monocyte cell number	J:69597
	increased neutrophil cell number	J:69597
Icam1^tm1Jcgr/Icam1^tm1Jcgr Tg(INS-Il10)#Sar/0 NOD.Cg-Icam1^tm1Jcgr Tg(INS-Il10)#Sar	decreased susceptibility to autoimmune diabetes	J:66103
	periinsulitis	J:66103
Icam1^tm1Jcgr/Icam1^tm1Jcgr Vcam1^tm1Dmil/Vcam1⁺ involves: 129S4/SvJae * C57BL/6	decreased cell chemotaxis	J:227109
Icam1^tm1Jcgr/Icam1^tm1Jcgr Vcam1^tm1Dmil/Vcam1^tm1Dmil involves: 129S4/SvJae * C57BL/6	decreased cell chemotaxis	J:227109
	impaired macrophage chemotaxis	J:227109

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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