Sele^tm2Alb
Targeted Allele Detail

Summary

• Symbol: Sele^tm2Alb
• Name: selectin, endothelial cell; targeted mutation 2, Arthur L Beaudet
• MGI ID: MGI:3767067
• Synonyms: E/P^-
• Gene: Sele Location: Chr1:163875773-163885246 bp, + strand Genetic Position: Chr1, 71.35 cM
• Alliance: Sele^tm2Alb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33135
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence extending from within exon 4 through a portion of 6 was replaced by an hprt minigene inserted by homologous recombination. This plasmid construct was electroporated into AB2.1 ES cells carrying a P-selectin (Selp) mutation (J:24239) and clones with the two mutations in cis were used to produce Sele/Selp double mutants. (J:33135)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sele Mutation: 52 strains or lines available

References

• Original: J:33135 Bullard DC, et al., Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J Exp Med. 1996 May 1;183(5):2329-36
• All: 29 reference(s)