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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Htr2c
5-hydroxytryptamine (serotonin) receptor 2C
MGI:96281
77 phenotypes from 8 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Htr2ctm1.1Eme/Y
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 		abnormal pilomotor reflex J:163043
decreased body length J:163043
decreased body weight J:163043
decreased food intake J:163043
decreased grip strength J:163043
dehydration J:163043
hunched posture J:163043
hypotonia J:163043
impaired coordination J:163043
increased energy expenditure J:163043
increased food intake J:163043
lethality at weaning, incomplete penetrance J:163043
mottled coat J:163043
postnatal growth retardation J:163043
postnatal lethality, incomplete penetrance J:163043
Htr2ctm1.1Eme/Htr2c+
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 		decreased body weight J:163043
decreased food intake J:163043
postnatal growth retardation J:163043
Htr2ctm1.1Eme/Htr2ctm1.1Eme
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 		decreased body weight J:163043
postnatal growth retardation J:163043
Htr2ctm1Arte/Y
involves: C57BL/6 		normal behavior/neurological phenotype J:228775
normal homeostasis/metabolism phenotype J:228775
impaired passive avoidance behavior J:228775
increased circulating corticosterone level J:228775
increased coping response J:228775
Htr2ctm1Jke/Y
B6.129-Htr2ctm1Jke 		decreased lean body mass J:147514
hyperactivity J:147514
impaired behavioral response to xenobiotic J:147514
increased circulating leptin level J:147514
increased percent body fat/body weight J:147514
increased susceptibility to diet-induced obesity J:147514
increased white adipose tissue amount J:147514
polyphagia J:147514
premature death J:147514
tonic-clonic seizures J:147514
Htr2ctm1Jke/Y
Tg(Pomc1-cre)16Lowl/0
B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl 		normal adipose tissue phenotype J:147514
normal behavior/neurological phenotype J:147514
normal growth/size/body region phenotype J:147514
normal homeostasis/metabolism phenotype J:147514
premature death J:147514
tonic-clonic seizures J:147514
Htr2ctm1Jul/Y
B6.129S-Htr2ctm1Jul 		abnormal response to new environment J:51567
abnormal response/metabolism to endogenous compounds J:50262
abnormal spatial learning J:51567
abnormal tumor necrosis factor level J:50262
hyperglycemia J:50262
impaired glucose tolerance J:50262
increased circulating insulin level J:50262
increased circulating leptin level J:50262
increased epididymal fat pad weight J:50262
increased renal fat pad weight J:50262
increased susceptibility to age related obesity J:50262
increased susceptibility to diet-induced obesity J:50262
increased white adipose tissue amount J:50262
insulin resistance J:50262
polyphagia J:50262
reduced long-term potentiation J:51567
Htr2ctm1Jul/Y
either: (involves: 129S2/SvPas * C57BL/6J * DBA/2) or (involves: 129S4/SvJae * C57BL/6J * DBA/2) 		normal behavior/neurological phenotype J:24339
impaired behavioral response to xenobiotic J:24339
increased body weight J:24339
increased epididymal fat pad weight J:24339
increased grooming behavior J:24339
increased renal fat pad weight J:24339
increased susceptibility to pharmacologically induced seizures J:24339
increased white adipose tissue amount J:24339
normal nervous system phenotype J:24339
polyphagia J:24339
premature death J:24339
sporadic seizures J:24339
tonic seizures J:24339
tonic-clonic seizures J:24339
Htr2ctm1Knk/Y
B6.Cg-Htr2ctm1Knk 		abnormal body temperature J:142503
abnormal metabolism J:142503
decreased body fat mass J:142503
decreased body length J:142503
decreased body mass index J:142503
decreased body weight J:142503
decreased brown adipose tissue mass J:142503
decreased circulating cholesterol level J:142503
decreased circulating glucose level J:142503
decreased circulating insulin level J:142503
decreased circulating insulin-like growth factor I level J:142503
decreased circulating leptin level J:142503
decreased circulating triglyceride level J:142503
decreased locomotor activity J:142503
decreased white adipose tissue amount J:142503
enhanced behavioral response to xenobiotic J:142503
normal homeostasis/metabolism phenotype J:142503
increased basal metabolism J:142503
increased circulating ghrelin level J:142503
increased circulating growth hormone level J:142503
increased physiological sensitivity to xenobiotic J:142503
increased susceptibility to xenobiotic induced morbidity/mortality J:142503
polyphagia J:142503
postnatal growth retardation J:142503
postnatal lethality, incomplete penetrance J:142503
slow postnatal weight gain J:142503
Htr2ctm1Knk/Htr2c+
B6.Cg-Htr2ctm1Knk 		slow postnatal weight gain J:142503
Htr2ctm1Knk/Y
C.Cg-Htr2ctm1Knk 		slow postnatal weight gain J:142503
Htr2ctm1Knk/Htr2ctm1Knk
B6.Cg-Htr2ctm1Knk 		decreased body length J:142503
decreased body mass index J:142503
decreased body weight J:142503
postnatal lethality, incomplete penetrance J:142503
slow postnatal weight gain J:142503
Htr2ctm1Knk/Htr2ctm1Knk
C.Cg-Htr2ctm1Knk 		slow postnatal weight gain J:142503
Htr2ctm1Knk/Htr2ctm2Knk
B6.Cg-Htr2ctm1Knk/Htr2ctm2Knk 		slow postnatal weight gain J:142503
Htr2ctm2Jke/Htr2ctm2Jke
Tg(Pomc1-cre)16Lowl/0
involves: 129X1/SvJ * C57BL/6J * FVB/N 		abnormal respiratory quotient J:207704
decreased oxygen consumption J:207704
normal growth/size/body region phenotype J:207704
normal homeostasis/metabolism phenotype J:207704
hyperactivity J:207704
hyperglycemia J:207704
increased body weight J:207704
increased circulating glucagon level J:207704
increased circulating glucose level J:207704
increased circulating insulin level J:207704
increased energy expenditure J:207704
increased food intake J:207704
increased oxygen consumption J:207704
increased susceptibility to diet-induced obesity J:207704
insulin resistance J:207704
normal mortality/aging J:207704
Htr2ctm2Jke/Htr2ctm2Jke
Tg(Pomc-cre/ERT2)#Jke/0
involves: 129X1/SvJ * C57BL/6J 		normal growth/size/body region phenotype J:207704
normal homeostasis/metabolism phenotype J:207704
increased body weight J:207704
increased circulating glucagon level J:207704
increased circulating glucose level J:207704
increased circulating insulin level J:207704
increased food intake J:207704
increased oxygen consumption J:207704
Htr2ctm2Jke/Y
Tg(Pomc1-cre)16Lowl/0
involves: 129X1/SvJ * C57BL/6J * FVB/N 		abnormal respiratory quotient J:207704
decreased oxygen consumption J:207704
normal growth/size/body region phenotype J:207704
normal homeostasis/metabolism phenotype J:207704
hyperactivity J:207704
hyperglycemia J:207704
increased body weight J:207704
increased circulating glucagon level J:207704
increased circulating glucose level J:207704
increased circulating insulin level J:207704
increased energy expenditure J:207704
increased food intake J:207704
increased oxygen consumption J:207704
increased susceptibility to diet-induced obesity J:207704
insulin resistance J:207704
normal mortality/aging J:207704
Htr2ctm2Jke/Y
Tg(Pomc-cre/ERT2)#Jke/0
involves: 129X1/SvJ * C57BL/6J 		normal growth/size/body region phenotype J:207704
normal homeostasis/metabolism phenotype J:207704
increased body weight J:207704
increased circulating glucagon level J:207704
increased circulating glucose level J:207704
increased circulating insulin level J:207704
increased food intake J:207704
increased oxygen consumption J:207704
Htr2ctm2Jke/Y
Tg(Zp3-cre)93Knw/0
involves: 129X1/SvJ * C57BL/6J 		hyperglycemia J:207704
increased susceptibility to diet-induced obesity J:207704
premature death J:207704
seizures J:207704
Htr2ctm2Knk/Y
either: B6.Cg-Htr2ctm2Knk or C.Cg-Htr2ctm2Knk 		normal growth/size/body region phenotype J:142503
normal homeostasis/metabolism phenotype J:142503
Htr2ctm2Knk/Htr2ctm2Knk
either: B6.Cg-Htr2ctm2Knk or C.Cg-Htr2ctm2Knk 		normal growth/size/body region phenotype J:142503
normal homeostasis/metabolism phenotype J:142503
Htr2ctm2Lex/Htr2ctm2Lex
involves: 129S5/SvEvBrd * C57BL/6J 		normal adipose tissue phenotype J:185494
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory