Htr2c^tm1Jke
Targeted Allele Detail

Summary

• Symbol: Htr2c^tm1Jke
• Name: 5-hydroxytryptamine (serotonin) receptor 2C; targeted mutation 1, Joel K Elmquist
• MGI ID: MGI:3841486
• Synonyms: 2C null, loxTB 5-HT2CR
• Gene: Htr2c Location: ChrX:145745509-145980273 bp, + strand Genetic Position: ChrX, 68.46 cM, cytoband D-F4
• Alliance: Htr2c^tm1Jke page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147514
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed transcription blocker cassette (loxTB) was inserted between exons 3 and 4. Expression is disrupted unless reactivated by cre mediated recombination. The absence of transcript expression was confirmed by RT-PCR on cerebral cortex, whole hypothalamus, arcuate nucleus of the hypothalamus, and brainstem extracts. (J:147514)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Htr2c Mutation: 12 strains or lines available

References

• Original: J:147514 Xu Y, et al., 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron. 2008 Nov 26;60(4):582-9
• All: 12 reference(s)