Hmgb1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hmgb1
high mobility group box 1
MGI:96113

29 phenotypes from 4 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hmgb1^tm1.1Dltg/Hmgb1^tm1.1Dltg Tg(Pdx1-cre)6Tuv/0 involves: C57BL/6 * FVB/N	normal endocrine/exocrine gland phenotype	J:225260
	increased circulating amylase level	J:225260
	increased circulating interleukin-6 level	J:225260
	increased circulating lactate dehydrogenase level	J:225260
	increased circulating tumor necrosis factor level	J:225260
	increased susceptibility to induced pancreatitis	J:225260
	pancreas necrosis	J:225260
Hmgb1^tm1.1Ttg/Hmgb1^tm1.1Ttg Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd	abnormal macrophage physiology	J:205499
	decreased macrophage cell number	J:205499
	normal hematopoietic system phenotype	J:205499
	impaired macrophage phagocytosis	J:205499
	increased circulating interleukin-1 beta level	J:205499
	increased circulating interleukin-18 level	J:205499
	increased interleukin-1 beta secretion	J:205499
	increased interleukin-18 secretion	J:205499
	increased macrophage apoptosis	J:205499
	increased sensitivity to induced cell death	J:205499
	increased susceptibility to bacterial infection	J:205499
	increased susceptibility to endotoxin shock	J:205499
Hmgb1^tm1.1Ttg/Hmgb1^tm1.1Ttg Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129P2/OlaHsd * C57BL/6 * DBA	increased circulating interleukin-1 beta level	J:205499
	increased circulating interleukin-18 level	J:205499
Hmgb1^tm1.1Ttg/Hmgb1^tm1.1Ttg Tg(Itgax-cre)1-1Reiz/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	increased circulating interleukin-1 beta level	J:205499
	increased circulating interleukin-18 level	J:205499
Hmgb1^tm1.1Ttg/Hmgb1^tm1.2Ttg Tg(CAG-cre)13Miya/0 involves: 129P2/OlaHsd * C57BL/6	neonatal lethality, complete penetrance	J:205499
Hmgb1^tm1Meb/Hmgb1^tm1Meb C.129P2-Hmgb1^tm1Meb	chromosome breakage	J:95963
Hmgb1^tm1Meb/Hmgb1^tm1Meb involves: 129P2/OlaHsd * BALB/c	atelectasis	J:55880
	decreased glycogen catabolism rate	J:55880
	eyelids open at birth	J:55880
	hypoglycemia	J:55880
	lethargy	J:55880
	neonatal lethality, complete penetrance	J:55880
Hmgb1^tm1Meb/Hmgb1^tm1Meb involves: 129P2/OlaHsd * CD-1	cachexia	J:55880
	neonatal lethality, complete penetrance	J:55880
	postnatal growth retardation	J:55880
	premature death	J:55880

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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