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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		C3
complement component 3
MGI:88227
41 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
C3tm1Crr/C3tm1Crr
C4btm1Crr/C4btm1Crr
Faslpr/Faslpr
involves: 129S4/SvJae * C57BL/6 * MRL 		abnormal immune system physiology J:127292
abnormal kidney morphology J:127292
abnormal renal glomerulus morphology J:127292
enlarged cervical lymph nodes J:127292
enlarged spleen J:127292
increased anti-double stranded DNA antibody level J:127292
increased anti-nuclear antigen antibody level J:127292
C3tm1Crr/C3tm1Crr
Cd59atm1Bpm/Cd59atm1Bpm
B6.129-Cd59atm1Bpm C3tm1Crr 		increased T cell proliferation J:122201
C3tm1Crr/C3tm1Crr
Del(2Cd59b-Cd59a)1Jha/Del(2Cd59b-Cd59a)1Jha
involves: 129/Sv * 129S4/SvJae * C57BL/6 		normal hematopoietic system phenotype J:170754
C3tm1Crr/C3tm1Crr
Dysftm1Kcam/Dysftm1Kcam
B6.129-Dysftm1Kcam C3tm1Crr 		muscle weakness J:171870
C3tm1Crr/C3tm1Crr
Faslpr/Faslpr
involves: 129S4/SvJae * C57BL/6 * MRL 		abnormal renal glomerulus morphology J:127292
decreased susceptibility to autoimmune disorder J:127292
normal immune system phenotype J:127292
C3tm1Crr/C3tm1Crr
Fcer1gtm1Rav/Fcer1gtm1Rav
Tg(Ins2-TFRC/OVA)296Wehi/0
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		decreased susceptibility to autoimmune diabetes J:122114
C3tm1Crr/C3tm1Crr
Tg(Ins2-TFRC/OVA)296Wehi/0
involves: 129S4/SvJae * C57BL/6 		decreased susceptibility to autoimmune diabetes J:122114
increased interferon-gamma secretion J:122114
increased T cell proliferation J:122114
insulitis J:122114
normal mortality/aging J:122114
C3tm1Crr/C3tm1Crr
Zbtb20Tg(PDGFB-APPSwInd)20Lms/?
involves: 129S4/SvJae * C57BL/6 		amyloid beta deposits J:135902
increased microglial cell activation J:135902
loss of hippocampal neurons J:135902
C3tm1Hrc/C3tm1Hrc
Cd55tm1Song/Cd55tm1Song
Cr1ltm1Hmo/Cr1ltm1Hmo
involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ 		abnormal platelet physiology J:138410
C3tm1Hrc/C3tm1Hrc
Cd55tm1Song/Cd55tm1Song
Cr1ltm1Hmo/Cr1ltm1Hmo
Vsig4tm1Gne/Vsig4tm1Gne
involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N 		abnormal platelet physiology J:138410
C3tm1Hrc/C3tm1Hrc
Cfhtm1.1Song/Cfhtm1.1Song
involves: 129 * C57BL/6 		no abnormal phenotype detected J:240426
C3tm1Hrc/C3tm1Hrc
Cr1ltm1Hmo/Cr1ltm1Hmo
involves: 129/Sv * 129X1/SvJ * C57BL/6 		abnormal complement pathway J:76578
normal mortality/aging J:59432
normal reproductive system phenotype J:86999
C3tm1Hrc/C3tm1Hrc
Lama2dy/Lama2dy
either: (involves: 129S2/SvPas * 129P1/ReJ) or (involves: 129X1/SvJ * 129P1/ReJ) 		abnormal physical strength J:102959
abnormal skeletal muscle morphology J:102959
decreased IgM level J:102959
dystrophic muscle J:102959
extended life span J:102959
increased body weight J:102959
increased IgG level J:102959
increased IgM level J:102959
skeletal muscle interstitial fibrosis J:102959
C3tm1Hrc/C3tm1Hrc
Lepob/Lepob
involves: 129 * C57BL/6 		abnormal energy expenditure J:80546
abnormal glucose homeostasis J:80546
abnormal lipid homeostasis J:80546
abnormal oxygen consumption J:80546
decreased body weight J:80546
decreased circulating insulin level J:80546
increased circulating free fatty acids level J:80546
increased triglyceride level J:80546
polyphagia J:80546
C3tm1Hrc/C3tm1Hrc
Vsig4tm1Gne/Vsig4tm1Gne
involves: 129/Sv * C57BL/6N 		normal immune system phenotype J:138691
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory