Cr1l^tm1Hmo
Targeted Allele Detail

Summary

• Symbol: Cr1l^tm1Hmo
• Name: complement C3b/C4b receptor 1 like; targeted mutation 1, Hector Molina
• MGI ID: MGI:2158683
• Synonyms: Crry^-
• Gene: Cr1l Location: Chr1:194781019-194813878 bp, - strand Genetic Position: Chr1, 98.43 cM
• Alliance: Cr1l^tm1Hmo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59432
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 5. Flow cytometry experiments demonstrated that no functional protein was detectable in embryonic fibroblasts derived from homozygous mice. (J:59432)

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cr1l Mutation: 30 strains or lines available

References

• Original: J:59432 Xu C, et al., A critical role for murine complement regulator crry in fetomaternal tolerance [see comments]. Science. 2000 Jan 21;287(5452):498-501
• All: 24 reference(s)