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Cr1l Gene Detail
Summary
  • Symbol
    Cr1l
  • Name
    complement C3b/C4b receptor 1 like
  • Synonyms
    Crry, mCRY
  • Feature Type
    protein coding gene
  • IDs
    MGI:88513
    NCBI Gene: 12946
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:194781019-194813878 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 98.43 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    478 from dbSNP Build 142
  • Strain Annotations
    24
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88513
 protein coding gene Chr1:194779690-194813894 (-)
129S1/SvImJ ENSMUSG00200004097
 protein coding gene Chr1:192609456-192610956 (-)
129S1/SvImJ ENSMUSGG00200054724
 protein coding gene Chr1:192594408-192609635 (-)
A/J ENSMUSG00195008427
 protein coding gene Chr1:192188107-192189607 (-)
A/J ENSMUSGG00195055476
 protein coding gene Chr1:192173057-192188286 (-)
AKR/J ENSMUSG00220004161
 protein coding gene Chr1:191445447-191446947 (-)
AKR/J ENSMUSGG00220054494
 protein coding gene Chr1:191430398-191445626 (-)
BALB/cJ ENSMUSGG00180055061
 protein coding gene Chr1:192239929-192255156 (-)
BALB/cJ ENSMUSG00180017831
 protein coding gene Chr1:192254977-192256477 (-)
C3H/HeJ ENSMUSG00175021512
 protein coding gene Chr1:192490142-192491642 (-)
C3H/HeJ ENSMUSGG00175055024
 protein coding gene Chr1:192475092-192490321 (-)
C57BL/6NJ ENSMUSG00215015738
 protein coding gene Chr1:191648500-191650000 (-)
C57BL/6NJ ENSMUSGG00215055559
 protein coding gene Chr1:191633452-191648679 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015075
 protein coding gene Chr1:185362155-185396325 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054958
 protein coding gene Chr1:192105896-192121125 (-)
CBA/J ENSMUSG00210003468
 protein coding gene Chr1:192120946-192122446 (-)
DBA/2J ENSMUSGG00185057606
 protein coding gene Chr1:196706720-196721949 (-)
DBA/2J ENSMUSG00185010035
 protein coding gene Chr1:196721770-196723270 (-)
FVB/NJ ENSMUSGG00205054450
 protein coding gene Chr1:191069411-191084638 (-)
FVB/NJ ENSMUSG00205004416
 protein coding gene Chr1:191084459-191085959 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230002186
 protein coding gene Chr1:196223944-196225444 (-)
LP/J ENSMUSGG00230055723
 protein coding gene Chr1:196208896-196224123 (-)
NOD/ShiLtJ ENSMUSG00190028477
 protein coding gene Chr1:192083618-192085118 (-)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010000039
 protein coding gene Chr1:194425922-194461052 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CR1, complement C3b/C4b receptor 1 (Knops blood group)
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CR1, complement C3b/C4b receptor 1 (Knops blood group)
  • Synonyms
    C3BR, C4BR, CD35, KN
  • Links
    NCBI Gene ID: 1378
    UniProt: P17927

  • Chr Location
    1q32.2; chr1:207496147-207641776 (+)  GRCh38
  • Human Ortholog
    CR1L, complement C3b/C4b receptor 1 like
  • Links
    NCBI Gene ID: 1379
    UniProt: Q2VPA4

  • Chr Location
    1q32.2; chr1:207645113-207738416 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 4 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die by E16.5 with abnormal C3 deposition. Mice homozygous for a null allele activated in single positive thymocytes exhibit T cell lymphopenia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    797
  • Tissues
    115
  • cDNA Data
    116
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12946 NCBI Gene Model | MGI Sequence Detail 32860 C57BL/6J ±  kb
    transcript NM_001355061 RefSeq | MGI Sequence Detail 1696 ZRU/MplStud  
    polypeptide Q64735 UniProt | EBI | MGI Sequence Detail 483 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 137
      Genomic 10
      cDNA 124
      Primer pair 3
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12142, MGD-MRK-2158
    References
    more
    • Summaries
      All 109
      Developmental Gene Expression 7
      Gene Ontology 12
      Phenotypes 43
    • Earliest
      J:8686 Aegerter-Shaw M, et al., Expansion of the complement receptor gene family. Identification in the mouse of two new genes related to the CR1 and CR2 gene family. J Immunol. 1987 May 15;138(10):3488-94
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory