78 phenotypes from 12 alleles in 13 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Akt1Gt1Pnt/Akt1Gt1Pnt Not Specified	no abnormal phenotype detected	J:135903
Akt1tm1.1Mjl/Akt1+ chimera involves: 129S6/SvEvTac * C57BL/6	abnormal blood vessel morphology	J:293971
	abnormal mammary gland duct morphology	J:293971
	abnormal mammary gland stroma morphology	J:293971
	biliary cyst	J:293971
	dilated bile duct	J:293971
	epidermal hyperplasia	J:293971
	mammary gland alveolar hyperplasia	J:293971
	mammary gland hyperplasia	J:293971
Akt1tm1Hem/Akt1tm1Hem involves: 129P2/OlaHsd	thin hypodermis	J:96826
	underdeveloped hair follicles	J:96826
Akt1tm1Hem/Akt1tm1Hem involves: 129P2/OlaHsd * C57BL/6	abnormal maternal decidual layer morphology	J:85181
	abnormal placenta development	J:85181
	abnormal placenta morphology	J:85181
	abnormal placenta vasculature	J:85181
	decreased body size	J:85181
	decreased body weight	J:85181
	decreased fetal size	J:85181
	decreased litter size	J:85181
	decreased placenta weight	J:85181
	decreased placental labyrinth size	J:85181
	decreased spongiotrophoblast size	J:85181
	decreased trophoblast glycogen cell number	J:85181
	pallor	J:85181
	postnatal growth retardation	J:85181
	postnatal lethality, incomplete penetrance	J:85181
	small placenta	J:85181
	weakness	J:85181
Akt1tm1Mbb/Akt1tm1Mbb B6.129P2-Akt1tm1Mbb	decreased body weight	J:182721
	decreased lean body mass	J:182721
	decreased percent body fat/body weight	J:182721
	decreased susceptibility to diet-induced obesity	J:182721
	increased basal metabolism	J:182721
	increased carbon dioxide production	J:182721
	increased oxygen consumption	J:182721
Akt1tm1Mbb/Akt1tm1Mbb involves: 129P2/OlaHsd	abnormal brain morphology	J:96823
	decreased body size	J:96823
	decreased hepatocyte number	J:96823
	decreased myocardial fiber size	J:96823
Akt1tm1Mbb/Akt1tm1Mbb involves: 129P2/OlaHsd * C57BL/6	normal behavior/neurological phenotype	J:185487
	decreased body weight	J:72176
	decreased prepulse inhibition	J:185487
	postnatal lethality, incomplete penetrance	J:72176
Akt1tm1Mjl/Akt1+ Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(cre/ERT)Nat involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	abnormal blood vessel morphology	J:293971
	abnormal mammary gland duct morphology	J:293971
	abnormal mammary gland stroma morphology	J:293971
	biliary cyst	J:293971
	dilated bile duct	J:293971
	mammary gland alveolar hyperplasia	J:293971
	mammary gland hyperplasia	J:293971
Akt1tm1Nhy/Akt1tm1Nhy involves: 129/Sv * C57BL/6	abnormal spermatogenesis	J:71404
	abnormal testis morphology	J:71404
	abnormal thymus morphology	J:71404
	decreased body weight	J:71404
	increased cellular sensitivity to gamma-irradiation	J:71404
	multinucleated giant male germ cells	J:71404
	oligozoospermia	J:71404
	premature death	J:71404
	seminiferous tubule degeneration	J:71404
	small seminiferous tubules	J:71404
Akt1tm1Pnt/Akt1tm1Pnt Tg(Lck-cre)1Cwi/0 Not Specified	no abnormal phenotype detected	J:135903
Akt1tm2.1Mbb/Akt1tm2.1Mbb involves: 129S4/SvJae * C57BL/6J * FVB/N	abnormal gluconeogenesis	J:182721
	abnormal glucose homeostasis	J:182721
	decreased body size	J:182721
	decreased body weight	J:182721
	decreased circulating leptin level	J:182721
	decreased circulating thyroxine level	J:182721
	decreased lean body mass	J:182721
	decreased liver triglyceride level	J:182721
	decreased percent body fat/body weight	J:182721
	decreased respiratory quotient	J:182721
	decreased susceptibility to diet-induced hepatic steatosis	J:182721
	decreased susceptibility to diet-induced obesity	J:182721
	decreased total body fat amount	J:182721
	hyperactivity	J:182721
	improved glucose tolerance	J:182721
	increased basal metabolism	J:182721
	increased carbon dioxide production	J:182721
	increased circulating adiponectin level	J:182721
	increased fatty acid oxidation	J:182721
	increased insulin sensitivity	J:182721
	increased oxygen consumption	J:182721
Akt1tm2.2Mbb/Akt1tm2.2Mbb involves: 129S4/SvJae * C57BL/6 * FVB/N	no abnormal phenotype detected	J:101977
Akt1tm2Mbb/Akt1tm2Mbb Tg(Ckmm-cre)5Khn/0 involves: 129S4/SvJae * C57BL/6J * FVB	normal growth/size/body region phenotype	J:182721
	normal homeostasis/metabolism phenotype	J:182721
Akt1tm2Mbb/Akt1tm2Mbb Tg(Nes-cre)1Kln/0 involves: 129S4/SvJae * C57BL/6J * SJL	normal growth/size/body region phenotype	J:182721
	normal homeostasis/metabolism phenotype	J:182721
Gt(ROSA)26Sortm1(Akt1/EGFP)Glas/Gt(ROSA)26Sor+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	decreased total body fat amount	J:94134
	increased muscle weight	J:94134
	increased skeletal muscle fiber size	J:94134
	increased skeletal muscle size	J:94134
Tg(KRT5-Akt1*)Jmpa/0 involves: C57BL/6 * DBA/2 * DBA/2J * FVB/N	abnormal oral mucosa morphology	J:144831
	abnormal palatine gland morphology	J:144831
	abnormal sublingual gland morphology	J:144831
	abnormal tumor morphology	J:144831
	decreased keratinocyte proliferation	J:144831
	increased adenocarcinoma incidence	J:144831
	increased carcinoma incidence	J:144831
	increased cell proliferation	J:144831
	increased squamous cell carcinoma incidence	J:144831
	increased trichoepithelioma incidence	J:144831
	oral erythroplakia	J:144831
	oral leukoplakia	J:144831