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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Bcl11b
B cell leukemia/lymphoma 11B
MGI:1929913
68 phenotypes from 8 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Bcl11bm1Jpk/Bcl11btm1Jpk
involves: BALB/c * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
abnormal ameloblast morphology J:199312
abnormal incisor morphology J:199312
abnormal tooth development J:199312
decreased birth body size J:199312
decreased birth weight J:199312
lethality at weaning, complete penetrance J:199312
long incisors J:199312
midface hypoplasia J:199312
short basicranium J:199312
short maxilla J:199312
Bcl11btm1.1(KOMP)Vlcg/Bcl11b+
B6N(Cg)-Bcl11btm1.1(KOMP)Vlcg/J
abnormal embryo size J:211773
embryonic growth retardation J:211773
hemorrhage J:211773
increased fasting circulating glucose level J:211773
increased vertical activity J:211773
Bcl11btm1.1(KOMP)Vlcg/Bcl11btm1.1(KOMP)Vlcg
B6N(Cg)-Bcl11btm1.1(KOMP)Vlcg/J
abnormal eyelid fusion J:211773
abnormal facial morphology J:211773
preweaning lethality, complete penetrance J:211773
Bcl11btm1.1Leid/Bcl11btm1.1Leid
Tg(KRT14-cre)1Ipc/0
involves: C57BL/6 * SJL
abnormal epidermal layer morphology J:147182
abnormal epidermis stratum corneum morphology J:147182
impaired skin barrier function J:147182
Bcl11btm1.2Leid/Bcl11btm1.2Leid
involves: C57BL/6 * SJL
abnormal corneocyte morphology J:147182
abnormal epidermal layer morphology J:147182
abnormal epidermis stratum corneum morphology J:147182
abnormal epidermis stratum granulosum morphology J:147182
abnormal suckling behavior J:147182
absent T cells J:147182
eyelids open at birth J:147182
impaired skin barrier function J:147182
neonatal lethality, complete penetrance J:147182
thin epidermis J:147182
thymus hypoplasia J:147182
Bcl11btm1.2Leid/Bcl11btm1.2Leid
involves: ICR
abnormal ameloblast differentiation J:146765
abnormal ameloblast morphology J:146765
abnormal enamel cord morphology J:146765
abnormal enamel knot morphology J:146765
abnormal incisor morphology J:146765
abnormal odontoblast morphology J:146765
abnormal outer dental epithelium morphology J:146765
abnormal stellate reticulum morphology J:146765
abnormal tooth development J:146765
small incisors J:146765
small molars J:146765
Bcl11btm1Avram/Bcl11btm1Avram
Tg(Cd4-cre)1Cwi/?
involves: 129 * C57BL/6 * DBA/2
abnormal leukocyte morphology J:128515
abnormal positive T cell selection J:128515
abnormal thymocyte activation J:128515
decreased CD4-positive, alpha beta T cell number J:128515
decreased CD8-positive, alpha-beta T cell number J:128515
decreased double-negative T cell number J:128515
decreased double-positive T cell number J:128515
enlarged mesenteric lymph nodes J:128515
increased B cell number J:128515
increased dendritic cell number J:128515
increased gamma-delta T cell number J:128515
increased NK cell number J:128515
increased spleen weight J:128515
spleen hyperplasia J:128515
thymus hypoplasia J:128515
Bcl11btm1Jpk/Bcl11btm1Jpk
involves: BALB/c * C57BL/6 * CBA
abnormal T cell differentiation J:83651
abnormal T cell morphology J:83651
abnormal T cell receptor beta chain V(D)J recombination J:83651
abnormal thymus cortex morphology J:83651
abnormal thymus medulla morphology J:83651
absent gastric milk in neonates J:83651
absent thymus corticomedullary boundary J:83651
decreased double-positive T cell number J:83651
eyelids open at birth J:83651
increased CD8-positive, alpha-beta T cell number J:83651
increased double-negative T cell number J:83651
increased thymocyte apoptosis J:83651
neonatal lethality, complete penetrance J:83651
thymus hypoplasia J:83651
Bcl11btm1Peli/Bcl11btm1Peli
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6J
abnormal NK cell differentiation J:161373
decreased metastatic potential J:161373
Bcl11btm2Jpk/Bcl11b+
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * C57BL/6J * DBA/2
normal immune system phenotype J:210122
Bcl11btm2Jpk/Bcl11b+
Tg(Lck-cre)1Jtak/0
involves: C57BL/6
abnormal cell cycle J:210122
abnormal T cell number J:210122
decreased CD4-positive, alpha beta T cell number J:210122
decreased CD8-positive, alpha-beta T cell number J:210122
decreased double-positive T cell number J:210122
decreased thymocyte number J:210122
increased double-negative T cell number J:210122
increased lymphoma incidence J:210122

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory