Bcl11b^tm1.2Leid
Targeted Allele Detail

Summary

• Symbol: Bcl11b^tm1.2Leid
• Name: B cell leukemia/lymphoma 11B; targeted mutation 1.2, Mark Leid
• MGI ID: MGI:3839578
• Synonyms: CTIP2^-, CTIP2^L-
• Gene: Bcl11b Location: Chr12:107876662-107969861 bp, - strand Genetic Position: Chr12, 59.1 cM, cytoband F1
• Alliance: Bcl11b^tm1.2Leid page

Defects in tooth development in Bcl11b^tm1.2Leid/Bcl11b^tm1.2Leid mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147182
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4 and an frt flanked neo cassette and a second loxP site were inserted downstream of exon 4 via homologous recombination. Exon 4 was then removed via Cre mediated recombination. Immunoblot analysis confirmed the absence of protein expression in the skin of homozygous mice. (J:147182)

Expression

In Mice Carrying this Mutation:	101 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl11b Mutation: 45 strains or lines available

References

• Original: J:147182 Golonzhka O, et al., Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation. J Invest Dermatol. 2009 Jun;129(6):1459-70
• All: 10 reference(s)