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| Caption | Defects in tooth development in Bcl11btm1.2Leid/Bcl11btm1.2Leid (Ctip2-/-) mice. H & E staining in coronal sections of wild-type (WT) (A, C, E, G, I, K, M, O) and mutant (B, D, F, H, J, L, N, P) mice at E14.5 (A, B, K, L), E16.5 (C, D, G-J, M, N), and E18.5 (E, F, O, P). (G-J) Higher magnification of (C) and (D), respectively, highlighting the lingual (G and H) and labial (I and J) sides of a developing incisor. Note the elongated dental cord (B, L, N), reduced and disorganized ameloblast layer (D, F, J), and loss of lingual/labial asymmetry (G-J) in mutant mice. The black asterisk (J) indicates a reduced stellate reticulum on the labial side of a developing incisor; the red asterisks represent ectopic ameloblast-like cells on the lingual-side mutant incisors (H) and lack of these cells in WT incisors (G); and the green asterisks indicate the epithelial expansion on the lingual side of mutant incisors (H) and the corresponding cells in WT mice (G). All histology studies presented in this figure are representative of at least 4 independent mice of each genotype. [Scale bars: (A-F, K-P) 100 um; (G-J) 200 um.] de, dental cord; em, enamel matrix; m1, first molar; mes, mesenchyme; o, odontoblast. | ||||
| Copyright | This image is from Golonzhka O, Proc Natl Acad Sci U S A 2009 Mar 17;106(11):4278-83. Copyright 2009 National Academy of Sciences, U.S.A. J:146765 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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