69 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Stk3tm1.1Jav/Stk3+ Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi involves: 129 * C57BL/6	increased hepatocellular carcinoma incidence	J:153945
	lethargy	J:153945
	liver hyperplasia	J:153945
Stk3tm1.1Jav/Stk3tm1.1Jav Stk4Gt(AJ0315)Wtsi/Stk4+ involves: 129 * C57BL/6	increased hepatocellular carcinoma incidence	J:153945
Stk3tm1.1Jav/Stk3tm1.1Jav Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi involves: 129 * C57BL/6	abnormal vitelline vasculature morphology	J:153945
	decreased embryo size	J:153945
	embryonic growth retardation	J:153945
	embryonic lethality during organogenesis, complete penetrance	J:153945
	enlarged pericardium	J:153945
	failure of initiation of embryo turning	J:153945
	open neural tube	J:153945
	pale yolk sac	J:153945
Stk3tm1.1Jav/Stk3tm1.1Jav Stk4tm1Kina/Stk4tm1Kina Tg(Nkx2-1-cre)2Sand/? involves: 129 * C57BL/6	abnormal lung development	J:197340
	abnormal pulmonary alveolus morphology	J:197340
	emphysema	J:197340
	increased lung endothelial cell proliferation	J:197340
	lung inflammation	J:197340
	postnatal lethality	J:197340
	primary atelectasis	J:197340
	pulmonary hyaline membrane formation	J:197340
Stk3tm1.1Jav/Stk3tm1Jav Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi involves: 129 * C57BL/6	decreased sensitivity to induced cell death	J:153945
	increased hepatocellular carcinoma incidence	J:153945
	increased hepatocyte proliferation	J:153945
	liver hyperplasia	J:153945
Stk3tm1.1Rjo/Stk3tm1.1Rjo Stk4tm1.1Rjo/Stk4tm1.1Rjo Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL	abnormal hepatocyte morphology	J:156531
	abnormal liver morphology	J:156531
	abnormal liver sinusoid morphology	J:156531
	normal homeostasis/metabolism phenotype	J:156531
	increased hepatocellular carcinoma incidence	J:156531
	increased hepatocyte apoptosis	J:156531
	increased hepatocyte proliferation	J:156531
	increased liver tumor incidence	J:156531
	increased liver weight	J:156531
Stk3tm1.1Yy/Stk3+ Stk4tm1.1Yy/Stk4tm1.1Yy involves: C57BL/6 * CBA	abnormal liver physiology	J:156541
	abnormal response/metabolism to endogenous compounds	J:156541
	decreased circulating alanine transaminase level	J:156541
	decreased circulating aspartate transaminase level	J:156541
	decreased hepatocyte apoptosis	J:156541
	decreased susceptibility to induced morbidity/mortality	J:156541
Stk3tm1.1Yy/Stk3tm1.1Yy Stk4tm1.1Yy/Stk4tm1.1Yy involves: C57BL/6 * CBA	abnormal embryo development	J:156541
	decreased fibroblast apoptosis	J:156541
	decreased hepatocyte apoptosis	J:156541
	embryonic growth retardation	J:156541
	embryonic lethality during organogenesis, complete penetrance	J:156541
Stk3tm1.1Yy/Stk3tm1Yy Stk4tm1.1Yy/Stk4tm1.1Yy involves: C57BL/6 * CBA	abnormal liver physiology	J:156541
	abnormal response/metabolism to endogenous compounds	J:156541
	decreased circulating alanine transaminase level	J:156541
	decreased circulating aspartate transaminase level	J:156541
	decreased hepatocyte apoptosis	J:156541
	decreased susceptibility to induced morbidity/mortality	J:156541
Stk3tm1.1Yy/Stk3tm1Yy Stk4tm1.1Yy/Stk4tm1.1Yy involves: C57BL/6 * CBA	increased circulating alanine transaminase level	J:156541
	increased circulating aspartate transaminase level	J:156541
	increased liver tumor incidence	J:156541
Stk3tm1.1Yy/Stk3tm1Yy Stk4tm1.1Yy/Stk4tm1.1Yy Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ involves: C57BL/6 * CBA * DBA	abnormal hepatocyte morphology	J:156541
	abnormal liver morphology	J:156541
	enlarged liver	J:156541
	increased hepatocyte apoptosis	J:156541
	increased hepatocyte proliferation	J:156541
Stk3tm1.1Yy/Stk3tm1Yy Stk4tm1.1Yy/Stk4tm1.1Yy Tg(CAG-cre/Esr1*)5Amc/0 involves: C57BL/6 * CBA	enlarged heart	J:156541
	enlarged liver	J:156541
	enlarged spleen	J:156541
	enlarged stomach	J:156541
	increased carcinoma incidence	J:156541
	increased hepatocellular carcinoma incidence	J:156541
	increased hepatocyte proliferation	J:156541
	increased liver tumor incidence	J:156541
Stk3tm1Dlim/Stk3tm1Dlim Stk4tm1Dlim/Stk4tm1Dlim Not Specified	abnormal angiogenesis	J:155001
	abnormal blood vessel morphology	J:155001
	abnormal cell proliferation	J:155001
	abnormal chorion morphology	J:155001
	abnormal embryo development	J:155001
	abnormal embryonic hematopoiesis	J:155001
	abnormal embryonic neuroepithelium morphology	J:155001
	abnormal heart development	J:155001
	abnormal neural plate morphology	J:155001
	abnormal placenta development	J:155001
	abnormal placenta labyrinth morphology	J:155001
	abnormal placental labyrinth vasculature morphology	J:155001
	abnormal placental transport	J:155001
	abnormal vascular branching morphogenesis	J:155001
	abnormal vascular endothelial cell morphology	J:155001
	abnormal vitelline vasculature morphology	J:155001
	decreased embryo size	J:155001
	decreased trophoblast giant cell number	J:155001
	embryonic growth retardation	J:155001
	embryonic lethality during organogenesis, complete penetrance	J:155001
	incomplete embryo turning	J:155001
	increased embryonic tissue cell apoptosis	J:155001
	increased placenta apoptosis	J:155001
	small ectoplacental cone	J:155001
Stk3tm1Jav/Stk3tm1Jav Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi involves: 129 * C57BL/6	increased hepatocellular carcinoma incidence	J:153945
	increased hepatocyte proliferation	J:153945
	liver hyperplasia	J:153945
Stk3tm1Jav/Stk3tm1Jav Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ involves: 129 * 129P2/OlaHsd * C57BL/6 * DBA	increased hepatocellular carcinoma incidence	J:238319
Stk3tm1Jav/Stk3tm1Jav Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ involves: 129 * C57BL/6	increased hepatocellular carcinoma incidence	J:153945
	liver hyperplasia	J:153945
Stk3tm1Jav/Stk3tm1Jav Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi Tg(KRT14-cre)1Amc/0 involves: C57BL/6 * CBA	normal integument phenotype	J:171057
Stk3tm1Yy/Stk3tm1.1Yy Stk4tm1.1Yy/Stk4tm1.1Yy Tg(Prrx1-cre)1Cjt/0 involves: C57BL/6 * CBA * SJL	abnormal cartilage morphology	J:156541
	abnormal limb bone morphology	J:156541
	abnormal long bone hypertrophic chondrocyte zone	J:156541
	abnormal skeleton physiology	J:156541
	decreased length of long bones	J:156541
	short limbs	J:156541