Stk3^tm1.1Rjo
Targeted Allele Detail

Summary

• Symbol: Stk3^tm1.1Rjo
• Name: serine/threonine kinase 3; targeted mutation 1.1, Randy L Johnson
• MGI ID: MGI:4430537
• Gene: Stk3 Location: Chr15:34875645-35155990 bp, - strand Genetic Position: Chr15, 14.34 cM, cytoband B3.3
• Alliance: Stk3^tm1.1Rjo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156531
• Parent Cell Line: RJ2.2 (ES Cell)
• Strain of Origin: (C57BL/6Brd-Tyr^c-Brd x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 5 and 6 were floxed and an FRT flanked neo cassette was placed in intron 6. The neo cassette was removed by flp-mediated recombination, leaving exons 5 and 6 flanked by loxP sites. (J:156531)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Stk3^tm1.1Rjo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stk3 Mutation: 47 strains or lines available

References

• Original: J:156531 Lu L, et al., Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1437-42
• All: 23 reference(s)