About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Card11
caspase recruitment domain family, member 11
MGI:1916978
98 phenotypes from 18 alleles in 17 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Card11em1(IMPC)Ccpcz/Card11em1(IMPC)Ccpcz
C57BL/6NCrl-Card11em1(IMPC)Ccpcz/Ccpcz 		abnormal spleen morphology J:211773
abnormal testis morphology J:211773
abnormal thymus morphology J:211773
abnormal uterus morphology J:211773
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:211773
decreased circulating alkaline phosphatase level J:211773
decreased effector memory CD8-positive, alpha-beta T cell number J:211773
decreased effector memory T-helper cell number J:211773
decreased spleen weight J:211773
enlarged thymus J:211773
hydrometra J:211773
increased CD4-positive, alpha-beta T cell number J:211773
increased CD8-positive, alpha-beta T cell number J:211773
increased CD8-positive, naive alpha-beta T cell number J:211773
increased freezing behavior J:211773
increased leukocyte cell number J:211773
increased lymphocyte cell number J:211773
increased T cell number J:211773
increased T-helper cell number J:211773
small spleen J:211773
small testis J:211773
Card11em1Welu/Card11+
involves: C57BL/6 		decreased marginal zone B cell number J:292926
decreased transitional stage T1 B cell number J:292926
decreased transitional stage T3 B cell number J:292926
impaired humoral immune response J:292926
increased transitional stage T2 B cell number J:292926
Card11em1Welu/Card11em1Welu
involves: C57BL/6 		abnormal B cell differentiation J:292926
abnormal germinal center B cell morphology J:292926
abnormal plasma cell differentiation J:292926
decreased B cell proliferation J:292926
decreased B-1 B cell number J:292926
decreased B-1a cell number J:292926
decreased germinal center B cell number J:292926
decreased IgG level J:292926
decreased IgM level J:292926
decreased marginal zone B cell number J:292926
decreased pre-B cell number J:292926
decreased transitional stage T1 B cell number J:292926
decreased transitional stage T3 B cell number J:292926
impaired humoral immune response J:292926
increased follicular B cell number J:292926
increased transitional stage T2 B cell number J:292926
Card11em2Welu/Card11+
involves: C57BL/6 		increased B-1 B cell number J:292926
increased marginal zone B cell number J:292926
Card11em2Welu/Card11em2Welu
involves: C57BL/6 		abnormal plasma cell differentiation J:292926
decreased mature B cell number J:292926
enlarged spleen J:292926
increased B cell proliferation J:292926
increased B-1a cell number J:292926
increased B-1b cell number J:292926
increased germinal center B cell number J:292926
increased marginal zone B cell number J:292926
increased pre-B cell number J:292926
increased transitional stage T2 B cell number J:292926
Card11em3Welu/Card11em3Welu
Not Specified 		decreased B-1 B cell number J:292926
decreased marginal zone B cell number J:292926
Card11m1Btlr/Card11m1Btlr
C57BL/6J-Card11m1Btlr 		abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology J:149767
abnormal cytokine secretion J:149767
abnormal cytotoxic T cell physiology J:139069
abnormal double-negative T cell morphology J:139069, J:149767
abnormal NK cell physiology J:139069
abnormal T cell activation J:139069
decreased B cell proliferation J:139069, J:149767
decreased B-1 B cell number J:139069, J:149767
decreased gamma-delta T cell number J:139069, J:149767
decreased IgG1 level J:139069, J:149767
decreased IgG2a level J:139069, J:149767
decreased IgG2b level J:139069, J:149767
decreased IgG2c level J:149767
decreased IgG3 level J:139069, J:149767
decreased IgM level J:139069, J:149767
decreased immunoglobulin level J:139069
decreased interferon-gamma secretion J:139069
decreased interleukin-2 secretion J:139069
decreased mature B cell number J:139069, J:149767
decreased memory T cell number J:139069, J:149767
decreased NK cell number J:139069, J:149767
decreased NK T cell number J:139069, J:149767
decreased regulatory T cell number J:149767
decreased T cell proliferation J:139069, J:149767
dermatitis J:139069, J:149767
normal immune system phenotype J:139069
Card11M2Btlr/Card11M2Btlr
involves: C57BL/6J 		decreased IgM level J:198555
Card11m3Btlr/Card11m3Btlr
C57BL/6J-Card11m3Btlr 		increased B-1a cell number J:221487
Card11M4Btlr/Card11+
C57BL/6J-Card11M4Btlr 		decreased B-1a cell number J:254856
increased B-1b cell number J:254856
Card11M4Btlr/Card11M4Btlr
C57BL/6J-Card11M4Btlr 		decreased B-1a cell number J:254856
decreased IgM level J:254856
impaired humoral immune response J:254856
increased B-1b cell number J:254856
Card11M5Btlr/Card11+
C57BL/6J-Card11M5Btlr 		decreased IgM level J:254879
impaired humoral immune response J:254879
increased B-1 B cell number J:254879
increased B-1a cell number J:254879
Card11M5Btlr/Card11M5Btlr
C57BL/6J-Card11M5Btlr 		decreased IgM level J:254879
impaired humoral immune response J:254879
increased B-1 B cell number J:254879
increased B-1a cell number J:254879
Card11M6Btlr/Card11M6Btlr
C57BL/6J-Card11M6Btlr 		increased alpha-beta T cell number J:272116
Card11M7Btlr/Card11M7Btlr
C57BL/6J-Card11M7Btlr 		abnormal T cell differentiation J:274762
decreased B cell number J:274762
decreased B-1 B cell number J:274762
decreased central memory CD4-positive, alpha-beta T cell number J:274762
decreased effector memory CD4-positive, alpha-beta T cell number J:274762
decreased effector memory CD8-positive, alpha-beta T cell number J:274762
increased CD4-positive, alpha-beta T cell number J:274762
increased CD8-positive, alpha-beta T cell number J:274762
increased T cell number J:274762
Card11m8Btlr/Card11m8Btlr
C57BL/6J-Card11m8Btlr 		abnormal B cell differentiation J:274940
decreased B cell number J:274940
decreased B-1a cell number J:274940
decreased effector memory CD8-positive, alpha-beta T cell number J:274940
decreased IgG level J:274940
decreased IgM level J:274940
decreased response to antigen J:274940
impaired humoral immune response J:274940
increased B-1b cell number J:274940
increased CD4-positive, alpha-beta T cell number J:274940
increased CD8-positive, alpha-beta T cell number J:274940
increased NK T cell number J:274940
increased T cell number J:274940
Card11tm1.1Litt/Card11tm1.1Litt
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
involves: 129P2/OlaHsd * 129X1/SvJ 		abnormal T cell activation J:180410
normal immune system phenotype J:180410
respiratory system inflammation J:180410
normal respiratory system phenotype J:180410
Card11tm1Litt/Card11tm1Litt
involves: 129P2/OlaHsd 		abnormal B cell proliferation J:89322
abnormal double-negative T cell morphology J:89322
abnormal T cell activation J:89322
abnormal T cell differentiation J:89322
abnormal T cell proliferation J:89322
absent B-1a cells J:89322
decreased IgA level J:89322
decreased IgG1 level J:89322
decreased IgG2b level J:89322
decreased IgG3 level J:89322
decreased IgM level J:89322
decreased immunoglobulin level J:89322
Card11tm1Pngr/Card11tm1Pngr
involves: 129P2/OlaHsd 		abnormal B cell differentiation J:84036
abnormal B cell physiology J:84036
abnormal interleukin-2 secretion J:84036
abnormal lymphocyte morphology J:84036
abnormal T cell activation J:84036
absent B-1a cells J:84036
decreased B cell proliferation J:84036
decreased IgA level J:84036
decreased IgE level J:84036
decreased IgG1 level J:84036
decreased IgG2a level J:84036
decreased IgG2b level J:84036
decreased IgG3 level J:84036
decreased IgG level J:84036
decreased IgM level J:84036
decreased immunoglobulin level J:84036
decreased NK cell number J:84036
Card11tm1Pngr/Card11tm1Pngr
involves: 129P2/OlaHsd * C57BL/6 		normal immune system phenotype J:122394
Card11tm1Vmd/Card11+
involves: 129S6/SvEvTac * C57BL/6N 		decreased B cell proliferation J:95800
Card11tm1Vmd/Card11tm1Vmd
involves: 129S6/SvEvTac * C57BL/6N 		abnormal B cell physiology J:95800
absent immature B cells J:95800
decreased B cell proliferation J:95800
decreased IgA level J:95800
decreased IgG1 level J:95800
decreased IgG2a level J:95800
decreased IgG2b level J:95800
decreased IgG3 level J:95800
decreased IgG level J:95800
decreased IgM level J:95800
decreased T cell proliferation J:95800
Card11tm1Xav/Card11tm1Xav
involves: 129 * C57BL/6 		abnormal T cell activation J:132226
abnormal T-helper 2 cell differentiation J:132226
decreased airway responsiveness J:132226
decreased circulating interleukin-4 level J:132226
decreased circulating interleukin-5 level J:132226
decreased IgE level J:132226
increased CD4-positive, alpha-beta T cell number J:132226
increased CD8-positive, alpha-beta T cell number J:132226
lung inflammation J:132226
Card11unm/Card11unm
C57BL/6JSfdAnu-Card11unm/Anu 		abnormal B cell differentiation J:84042
abnormal immune system physiology J:84042
abnormal T cell activation J:84042
decreased B-1 B cell number J:84042
decreased IgG3 level J:84042
decreased IgM level J:84042
decreased immunoglobulin level J:84042
dermatitis J:84042
erythroderma J:84042
increased IgE level J:84042
increased immunoglobulin level J:84042
increased inflammatory response J:84042
lymph node hyperplasia J:84042
spleen hyperplasia J:84042
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory